This funding represents the first awards under the Complement Animal Research in Experimentation (Complement‑ARIE) program, focused on developing, validating, and standardizing new approach methodologies (NAMs) — including advanced in vitro and computational models that better reflect human biology.
Key elements of the initiative include:
- Establishment of Technology Development Centers to accelerate NAM development
- A NAMs data hub and coordinating center to support data sharing and standards
- A validation and qualification network to enable regulatory acceptance through public‑private collaboration
- Initial pilot projects in areas such as inhalation toxicity, developmental neurotoxicity, and rare diseases
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