Psychedelika so wie Psilocybin haben eine lange Geschichte der medizinischen Anwendung. In den 1950er Jahren wurden Psychedelika für kurze Zeit in der Psychologie und Psychiatrie geschätzt, bevor ein gesetzliches Verbot Mitte der 1960er Jahre die Forschung stoppte. In den 1990er Jahren gab es erneut Forschungsinteresse, aber erst mit der Legalisierung von Cannabis ging es wieder richtig los.
Die nächste Ära der Psychedelika-Forschung wird wahrscheinlich durch eine Verlagerung von der pflanzlich-alternativen Behandlung hin zu verschreibungspflichtigen Arzneimitteln stattfinden. Durch eingehendes Verständnis und die Standardisierung der Wirkmechanismen könnten Psychedelika zum nächsten Blockbuster-Medikament werden und zur Behandlung einer Vielzahl psychischer Störungen eingesetzt werden.
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