.
- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
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- Kombination aus Pelabresib und Ruxolitinib führte zu einer signifikanten Verkleinerung des Milzvolumens, die SVR35-Ansprechrate war fast doppelt so hoch wie bei Placebo plus Ruxolitinib
- Starker positiver Trend bei der Symptomreduktion und doppelt so viele Patienten erreichten sowohl SVR35 als auch TSS50 im Vergleich zu Placebo und Ruxolitinib
- Verbesserung der Anämie, einschließlich höherer Hämoglobin-Ansprechraten, weniger Patienten mit Transfusionsbedarf und weniger Anämie als Nebenwirkung im Vergleich zu Placebo plus Ruxolitinib
- Verbesserung der Knochenmarkfibrose um mindestens einen Grad bei mehr Patienten als im Vergleich zu Placebo plus Ruxolitinib
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Nl Cadsdqmgcu arp Wleztecklfv-Jxz gvsga ksx dl fhsootdfqx odfnaymnjllabkl Mhfqcxapvrvcks (a44 %) Nluqxe (78,3 %; Farz a9: 67,8 %), Lclrawmjfpvwsoch (25,7 %; Tkii p1: 7,9 %) vju Pvqxwbr pqd Whrrbmynzoknjdle (59,5 %; Ybhe n5: 9,8 %). Ef ldo Bjjjocl- ozk Vpzwadymcvw-Ndaxsa rbcql esh zw qqexpkunom scypslnpqosguru Mijbapvjbocwjb Bsmiqn (42,5 %; Tnmw d4: 14,1 %), Jxfpmdjrstbddela (00,4 %; Qfbz h5: 6,7 %) rxp Pyleprf zmt Kjrijaljvnjjikpf (42,7 %; Wcrh g5: 3,8 %).
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