MANIFEST-2 erreichte den primären Endpunkt, SVR35-Ansprechrate hat sich fast verdoppelt (66 % versus 35 %)
Die wichtigsten sekundären Endpunkte zur Bewertung der Symptomreduzierung, TSS50 und die absolute Veränderung des TSS, zeigten signifikante Verbesserungen für Patienten mit intermediärem Risiko [p < 0,05, bzw. p < 0,02] und starke numerische Verbesserungen für gesamte Patientenpopulation
Pelabresib plus Ruxolitinib zeigten klinisch bedeutsame Verbesserung der Anämie gegenüber Placebo und Ruxolitinib
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