Die heute beim Gastrointestinal Cancers Symposium der American Society of Clinical Oncology (ASCO GI) in San Francisco präsentierten Daten bestätigen die gesteigerte Wirksamkeit von Erbitux® (Cetuximab) bei mCRC-Patienten (Darmkrebs) mit KRAS-Wildtyp-Tumor.
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Die randomisierte Phase-II-Studie CECOGa / CORE1.2.001 untersuchte den Einfluss des KRAS-Status auf die Wirksamkeit von Erbitux in Kombination mit FOLFOX oder FOLFIRI in der Erstlinientherapie des mCRC bei 117 Patienten. Die Ansprechrate (RR) lag bei Patienten mit KRAS-Wildtyp-Tumor bei 53% im Vergleich zu 36% bei Patienten mit mutiertem KRAS. Daneben zeigen die Studienergebnisse einen Trend zu einem verbesserten Gesamtüberleben (OS) bei Patienten mit KRAS-Wildtyp-Tumor. Bei diesen Patienten wurde ein pboqxqhf Rjioffzxpqucejj swn 53,1 Dlizozh bq Atdvjjjtv ym 21,9 Bjmpugk zes Jzwunkzne aen LJKU-Sermrtovbn (pt0,849) jrvirevjqk.4
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