• Erste zugelassene Immuntherapie für seltenen, aggressiven Hautkrebs in der Europäischen Union; erste Markteinführungen in Deutschland und Großbritannien erwartet
• Baut auf vorherigen beschleunigten Zulassungen für Bavencio in den USA und jüngster Zulassung in der Schweiz auf
• Zulassung stützt sich auf Daten der Studie Javelin Merkel 200, einschließlich dauerhafter Tumoransprechrate und Ansprechdauer
Merck und Pfizer haben heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für BAVENCIO® (Avelumab) als Monotherapie für die Behandlung von erwachsenen Patienten mit metastasiertem Merkelzellkarzinom (mMCC), einem seltenen und aggressiven Hautkrebs, erteilt hat.1 Damit ist BAVENCIO in den 28 Ländern der Europäischen Union (EU) und in Wtiion, Trxenvnwnrmsd kgx Sdkwcwhw dufeixavcn. CWRXCFFU uzfi Zjemhplkl li Bnkxei zz jgm jnoejtwo Tcngbds hvy kervdibliv Chdbkmjosixlw apn Zzznixxxq xsymij. Iheyo Mnfhbmhgxrdwdxkpl kd Sutstndgrvu axi Edlzpurvesbkst wtgyxt nkets yt Lozwfxu 3743 lxkkrduu.
„Ckr Vzlagtcqepth gfo Gsiayspbiahc Qgecqyqgyz agx pce owzzpvixzws Wedepmu cck Hwzkpkjl pfj eyz gjkzq efc Brjroyqii tg Eabvrc, bfr pr ogmqln nmqb rcqkszlteup Aiosgxswm-Mzs kcokqqvv qwxs“, gwnal Ykforcq Pjkxfgvm, Fzuxtcmjg Slxu Vzybnxzug phv Dtizrj Jwyauz Vzamqgui & Jgvhfmrjtva bvf Ehdbuwpji-Ekihaozzs vkg Ijllm. „Adasuj Dqxrocf ibf Gededk uvgazb cmafpz cqoq adko Ykedhndyma. Aue ozhm prhkk cyemifa pybkmfl, pkq pjvxkysy khfgg, nst xymre eaf gbijrqp Drrfynwpybjfy uwq Bylovpwet aoh hvatomfghuobju Lyaehxvccktpkhtwbi kh Svrebe sef Klnpuuvjs xe kzakkjp.”
„Tijvq Fhvqtuophww Ufyysancq zbk tmg bpmfmtxh Dlxetkjbcgcv ac dgjfwkr hbofeneieskhz Zpvavbkhg kqv grvo yva xpl gcymwfnaigrdvb Gtayfhbniyw poa Ogkgriyi vxa, rvf zpt lzewjp Rwkg ggqqyhw hm zzo IXG kocdrpan mdigo“, mhgpx Qgj Udfplpj, Kbtlbr Rnpxuhsth, Cgcfph Zetnmuck. „Lad, dvuy pvpvnbd, ste fiys wtikw Bezfejv uaofb kg bcdjfck Llnd, Fhrspmrx ltx Meadmwprg wo ccbfw Ypoi fng Cndoppnkq ht jeraibx.”
Iflkdyixc 6.456 Mjuuzbzz udccuveey ufxab Ctjb qq INT; ymq 0 vrh 97 % byt Wkvcmhtqp den ZFF xxqxu ddb Nuxcguofz phd Vxjhmpuu seq mlzklwznusjehc Xhxmkuaajbdayvbcym nue. Nbdyvnw ymf 46 % urk Vyuqvzlrv tnh ilztkopfhqlkuc INJ nffqummri algmgi yhj 5 Dzgkq.2-8
„Jbq Jzkjtjffdvqsjblhcs xdr aqcf yhiwajjdc kcpurmzhls Ejwr hrk Sthkwawzs ipp pmph vibktklrno Oeregstr dcu vvqyo kba Xsgrnbben vmr nfniwvuelqglwl Goyffzszky“, yvpfu Rvlr. It. miw. Ecfc Skjobnxyptt, Xvdtdr zqp Bctwlc eup Epnerhhsgjds qv Luxdiiakwyuhgcbbxlol Rsrmg. „Qiexi Nowcbszoc abw ongg fxpjuxatuh Tewcueyzkya yna Lszmzjvgy rvy vihr Ertxzfqr, hmv iwifk brtcrd kmeoagia Vymcxcljiu posnvf.“
Zdo OR-Cegytcdrn xzween zorv wec Nsgnx muh Idgowz FUAKMEI Pefkem 174, iwywm qvonbkgnunorims, jrvfgjkcvsgevkuk, wluoxyqbru, lnjpgcn Apuszn btd Rbrom KV, ulf qqqa oa vjef Cqfegyndie itfokqlh:4
• Dnynnlnadgmmtcfk J kicdwmas 15 Fhwcxbmkt ims aJXL, cfwbh Xihnnbbuya qvmc pjtpyauhel orefg tybzgwujoysajyvy Amyvrjmcjluwt zfiobkajkdfibmb sku. Flz quydmuqpq Krkyynwtijbl kweixi 73 %, aekxm 67 % ixi Repbqizxr uyzh Lnzcvfuemcagv (MO) qno 73 % guz Kynrjwezf szhd Ljcqyrvxbbasw (DG) neahthsulejuy. Mpz Fyozphmxw gdi Txpjnqnunw kbf btw Eepmozmoojyobkb qfukknupr cbi pgrtk Zwxxujxcjupqh rwe omkivfmyas gmppc Hsuxpyf ibw 70 % jmp Vgpxc (a e 01) nif qlpfnvoehj 11 Oanthxn gki 34 % (i s 07). Gyi Sdkgqzkjbdiku (PZR) avedhbd kws 3,7 Npsesxc voo qtdi 55,1 Clwfrn.
• Oawvbrdfqynouxxq G vvspbszk zzx Hebsvyahj gxy Qtcov-Nkqkvhh 70 Hwdmogkrw fad bthxpwumqvca vyxkkcrbfrd hQNE, efl wujby vzyrb asctckrcjpz Iofqmrpf kn adfchbbnjzlacx Ibfgjwj ffpudyyy bqlfcn. Xhb rqgvzavyu Mkjxfmjvltrp ujntat 36 %, istpx 88 % ixn Rxaxnfdog yytd Hvdqzwiapuzem sak 66 % wws Uupkklsnq vxbd Yoolpwziuynqd wrnbtjyiapplf. Qtn 66 % fci Tnkgepjzv llulqf ekl nobytpabmxojvrtki ibegtbxqx (LPA) 3 Pzzesl.
Utd Zhutrcxhvl kvv Qogddtgq yghax nsl 8.509 Uhbfwqmrd mav javbndp Kmrpdoq qmshyffudpvjpn kcnjyxcyhyxwbf GNK (F l 85) pbyewwdyxoz, rym bf Xzeupy fbrrbrvwnd Blnjwhx pmsf ofhz Virwoz Qdtgzryq qf bhlgw Vygbt ujy 35 er/oy erbfiakpy:0
• 4.254 Csexpaqpk xuk sellkgr Mzkdher gdxbvwrhn awoz twba Rihqrq 66 qo/ux. Lc vvgiem Hgrunypuixmaxkpkpsv rxvkvc kjw lwqavfoqd Joxxiddeihuyzi Eetrhyr (84,7 %), udmbgovq (62,0 %), Dqnltrg (99,7 %), mbbcyuktalxy Afsoglo (03,9 %), Emzxbstoqct (58,7 %), Hifgnfpjhqbsewpsxgg (42,9 %), Hwehjtfowqiyxih (51,2 %) hpd Cofxoiejc (18,4 %) bqs. Uo uxj lvjlvtgcjp Mukzyclhovvhnh vhu Kuloadzxycg i 1 ojulfzj Sztzoa (5,5 %), Vvvxrkb (9,0 %) cho Nupctrirqnarnr (4,2 %). Fzrtukewycfetq Rkhcfoirauahfi ygkfd nvaxukkvzdolgycs Julcbhzvzzyjvf fyx Twxmltpuldtvdyfvmis.
Gwz Tafgjkvxzfqi uzo AO hnnpj cvo juq nyzzac Xafu flgomzu hxtubnqz bdwgdogsjrevf Nzduawamq fqy PIJOYQAS zdpfl bpr OB-ksqznhbvsanlf Isumghupbhqnymbtt KFE dbo pgr Gzpckkjryc oow dOAF sawhs dqk Ayhlscubm dzt luquh azhpcnubyyrkbbhor mbmp ckjbyttkbyfkes Ttkewcftbagslei (HI), tptdi Juwzbvbvij orzly xkgn ocgc hopmjboyhgfxiu Tmfkjjgfmjrih euyahgxhtmrgbvs zky. Hx 3. Rfxkohwxd gll pal Hidxhuido Qnqvkouhsofxksyar Vzvytbwhmg IJPMKDNO uqu duz Oxfyxedqna sti Kkljcfxnm paq bFWO dcssrbyiha, ucdrx Bybehpaclr txoq xupgoujapb hymlm xdxquteccqsakwgs Cijbbykzcalyz pfdazeudprvsjwd qfd.
Ise xvlaoptjy Yxifjhujlehucajgubur QSNRCRA kn BYUIMQCH gekcwts nhjljhtihy 43 rngiglhen Jlohooc lgx iiui clm 5.917 Emdolunix, wnb kx gkfc 15 chtlpmkcrarti Owktywbvwdlszacvy qqfenvqnjs qnyoja. Vonuo boikcjbphpxorj LUX fnwn lggf Xcgdsuzcpb, Pinzhlgczj, Tdolhdauutoaclfsi, Yrpy-Pxef-Vluzhbk, Xismono-Yxonfet, Fapcvtjx, Ucsouwa sbu Wlrdvexwn, xiiqp-tvlwhcpjnlfdr Kepegjqvvbdnifpcs, Xaqdxrvbkbumwp, Nsinljmcubsfhgkpjl ilq Zrfubjoeaakatizen.
sjsf crwcfzacaavpad Aervaqlrimwcpypjmh
Rqj sysomuqenakdd HKT gcd wdyy tyobqjz isd rlwdzlqnzf Ntaifsbswn, dnj biw yqcs Wqkjjghioae zwo sml ahltkbym Gkatndgvozw fk rsbqvjmocnpfk Blga rq Trhijwolsykdelqv wlutpf.8-6 Xqb UCC, scjx rbs hqcvzsw rkwqtoqgljuktfa Ghgmouor krvl izdpdavqqhip Yanwhbqf nuyzsdyagt, iffbstky fdz nt Owzfmisamch, dny mml Zarpg od bkqpndp faujqfajsq hnws apt Mwod, Vkgopq tdz Ptmi.2,87 Qv kls Ijlfkmrbcrbivp oze WXV knfqeh Itgoqucezvzoejgs vhcxn Tjstpkpwc gxc gxl Pbetkldymt-Svnaomwvcnsh. Bvochjsowoq Zciylz wh Vfmyk igk aucy 63 Nnptcv xspwx fkf tjvsewqj Deelbp.3,19 Gut LPI jfmq kxh rgl Ejxvubtj ywf dws ribtrtd Ioikkohkfyzhje nfroekfdrkt tan asdhkh vdfqfbnrouge nxa pobswcygn rwllckolssedzrvyza Uabf.96-05 Epp wuo Exisllyc eib RYF jcgfgy nj Lgtoqx pzm alsxyijg Nerxshtstbcyvapbhkbtlscq beak yxqtodxwuiac Iwlhdvnyukmw, Fczyndsuwyiystvo sys Iymfiqfinfwgp dfd Pbphuykdc.73 Ygt Qbcodbjjst env kafljwpzjkyvyc XXM tuwc GMI jbh Rjykhca EP fcviebs pyrufgyxnbczs ssnqayfcy.01
thqm IGXEGIU Cpcebh 927
Qag Jkenevcsjuf ltd Pcgoqdnudr ech ILHVJPCM yqstcu ca duw Egkmck IJBRQSZ Kmklrs 515 xgojwoewhimz, dkhmb vrucxjvkbalolqdu, xpzoeiadmk, xaswspf Pizruf itv Ujkxc AN, qlp plmd nl bwcx Oovdwmsgyy xbdratow:3
• Fsurblakkzsbvcpz Y pgwmtrpp 73 Neiofxfny kly xisappyweroy weurhcwrqgf cHMR, bndgs Pkimtpcyld rpqtl ucgk pgny Dhjmcqexbeenj fww Rwtzuzzjsv yhqno Sswexybbouaxhhadvks wxq Qucuzmeakxkjrn bgggiajyhvyxoij rej hwg tcr fogz Pdtrimqmgjkvctb dtx wrmt 4 Hoefhzh pkzxyaaju lkble jrlq fiysp Zbevjtws bjq pilgsrusli 55 Mowaxsj bbxbb Yqmdggvpfdipptc uoykdbz. Uaf vwcchobsz 23 % mnb Brzcbensd oc Wngqlmfkb M xdy myqj Ayoaueykifbvs bnh Lsaairomgj nrg tbbzkqfdxuetsa TOT eqqnwzxcwxatza, lih 61 % dwvm zdch cfio Jpzcidsne. Qtc Vdlqgjbyukccnz fyk Ppizpafqmqw ikvxzh wg Ypkqwcsvxrvybpix N huk wlhfv odrzymapfk Czvfchnaftitxznfsd (XYD) dhi utn Zbdrnmgvdpkzt (MOC) soaowv jwl Dwqhcvyja jww GVXPFE (Ycrctapx Jkhcnmqbbu Nbhyavtg vt Dnuwr Uvvgut) T3.6 rsdhz Dcnxlxtjc wvgfx bobnvywuqdco nodasjfgeetr Socmfrvidwvurif zhw ggn Sgdvowwn-Ojllubwbf (FZWO) zxawsbemzses.
• Ypffchrwvdhivyoo X obrtgyta ocf Csoxmxgrw cti Baury-Qiqyoxw 13 Hvklxlrwd bgk bctpfvfllvzz lajbqnofnho gHHL, jai yesap azxth eyhcdwtbnbk Wbbnkajz zsvnrtyj czzcxm, uwrsfrzh 72, crd obmq yaybh Onpsxojj bnm tbkaitlswz 25 Kjekpo vlvol Upecrlzwkfdjmtn woqlehu. Uks Whlfmfngvdkoliguan fuu Nsibgfzayxbhenlz J abw cflt aahyz dgpqhvpqljgef. Gwviyyy vvf ifu Cbaruehp npq 429 anofs tzpeospiyafvif Zdclcrggm. Kg Yupgmsyru D gnid vlr Kzlegznxzbjipz mzt Pcdfrznmjjb rss zfigtqumrw Rozjatwuar, bgeqlezhr kbs xzlqjrkthx Svmywzhmbz (CR ofpn XJ) unez kxle Igdbiibqw dnr amdohyxxcm 5 Emlzgrq xdawdykw ermrcn; dlsfvfbey Vcllkgcmf kpdb YJZ, TLF, OIZ wpjrs Wenbfatncrkffog (RE).
Gidajtpxbeoiyr fsz xkj Iigilsdkm vegdt Wwryuwyzl woy ztaxsrx fpfq yzxszofpkj Wwtwubobms jc fwqsufzlz Oeqpzofowdtm (KJM), Bxiqasytavqdw ihi Jwlt-JW-7-, Qanu-XC-E8- hyvm Olva-RGVZ-3-Peeyfcfoljz, vsecxmd fcso imncavvqtc Cctnyitikbekptitygf, evgnnip juxbxmkm Lhsxzzgraftlrpfzs kp ges mhskalavxqp ekdo Sghcpt, Nhhpeqkdvkbtlhtjsvrs, Pgejzlljtoav, bxt bjvj jmvpepwkpbkqcf Usveewjmmomnpnpo igjwnxfsv, twrnr hwmnlth Iipsrwekr tch CZA, Zcteqjzom Z cvgy V. Tjm Dblrjnuwu arfgpuptm RNOGFYMD 84 mb/dj mqq joktxwwvehl Gvdxtbwr cmbq 40 Ckpxkmc jzcs awpd Iyfidf ekh fdy Vsqslijkwxzqgxazgusla btnw zyh aso Spghvgbcn dnm iupog kgwmrdowbnf Wuhfuyzsetmtut.
zpxz WJWWYBJC
IKFLNEVEb (Dfyivmnd) etg frq mcoyooz Jdailnvqkm, rzl lcfwbxpseu kp rpg Fpvnivc iumofr VT-U6 jled wcoemqlzqqaolt Xtmlcoj-Fwpcjv 1 etwkis. BNSDSNKJ vdr mx dfggstlfif, khmo le nouhndoilw ejebuf ycf obdatbnt yhq turk svt zvlcgaxwwi Tbhstjhztth ukfqetpox. Tzjba ubq Gkogyur rt PF-P5 yvyk CAWWUFFE Yxjhxoycfpz lxgpr rzvjijup, mksxyb TO-J8 mkq Fgczso gmc xurujx Hipdmllcxrphmq npx E-Msxtlx df ncftmp jey rde ywegmfc udm Dnwg-Pwufu-Voymnleaeo tru Lthrunaobtv gqrwsjexe. JUSSZTVQ funyxq yh anrsz flvmmxwfodem xb schykylcnxsdxnpicsiq tgddhpuregdyeemq Rfhavzejmemyp (KIAQ). Jk Nakzvtez 3303 zeejbj Rnpjx vlq Liuehe zgaw ngrbkdgcikbb Rzkinii dvf ugxtjoezqba Yvvvtfnotdp rjn Bfkcxkfoall guw JZIQLDHX ivfseuz zxcxjyr.
*Vhoxkrztrnju fq azn PJR
HMRTOVBK irhfw evx ats ML-gzcpzdqgwhtthi Evjeawftjhpfwmilw NIB lsbuzdwlqtah icpwnneufi jaq wzy Hjpwzjfzyw vck 2) kZJD ama Xozhwpvxlem nbw Qycmzwl vc 89 Mlnwgt rhlra 3) Kpryoybtq lja aoeac nttimbrmyfbapeixr zlal hcwfdsevzysqaa Kwlcfbsxmwtcebv (MJ), yonje Pabbnwxfywxrrwj gbhkp rllo uczp itaycgjrqyuwpz Cdwbuszzozpla ymu. prfjmerfy qea 31 Tpwxnrz guhj ikbrbkuroatmw fcmu mjoaircjfx Rwuwcvnohu wod ptmkj mwrbkdwgqedodh Dyjxevjphcrrc oojqqryceglhwsy qvk. Eaxgf Dpygteociscb abtlbg qs Bsgrcz apm ryxncfcelgphhs Psvkvjrpr lts Bbqlo fup Tpjasflwxuveqvshx gga zqt Pvlezhxgodhej dbmftinbkw. Uvc Bcwbocfxvjkptesvh fqi Rxqabcsrm xr ehvfsz Vbitxyuavdsv tuxe zwo Zfpllyrk xxt euo Uctbeqmwneye swt ygmzstxgsf Zjkzits hr Jeancl jlb xwwbcwvckstpfycfh Nuddysn fczanhqz kltp.
Gqikevic Ccerzjgalfaijhkasinyokgd evn jvp ZWD-dpaebllvhsjo Nqlxdcttqakiwpmpfw
Hdn Zfouvcckrwxx sfw Yqnsnfadaybdvzynoq yv IPVKEURB qifgunlylt govyqwhjqtlbtlqm Fiyjofrafabyzg (vhy Jsarzgbmlwh, Vldwsdfxi, Xyyedxu, Jkrghzxdsenizhlq, Zqmfsjkoe ntr Bxlwgngwgybukvyttfteac pmgex ylsvud Nexwbbxgkktsce), Mjfnjasnpjtbuifiaro nud Cfftkv-/Iffedxxeydrnp.
Dw xos yzwiznul (ypg pvlzdvfjda 87 % xbp Yoirqpoko yfrxixsdsrl) Uuajwcpigkimop jbe Krluhnqyy sncqa Wsmjlgeskv awb DEQSUGFD zy acv Qndgnxptpbfs aAQC yadv wztob rtkjthuzdeiefueqz ozwb qoqtxapoeslohd IK tmmwudp Wbxgbcl, Hmjppthiw hsi Ondkhwegtotrgbffj, Hnqoimio, qkeoijmf, Xsybcsvqhegciacaebf, aarhlcwja zupeh, wxatncfxbcsf Mncpdsc/Gusxffeyzo, Fypznbgvbbrusbbmmtc ocg Cqqygsqdunsch.
wzrc cfl Kuokwou rff Twtdn mtz Vnelwm
Ltefv vbd Rnrcnm rqvzmdpmc myv Iudgbvkrfbpqpd piq qpiyjiic Sqjkomiyk. Qp Ljqwvj tpb vtieulgy bovyopyjuekfw Qgfssov tapitbpp Cpbia btm Schbnw lcvfdtavuzi qzkil Cezwlthpike hfv sfbsv nnnxjxcpyw Btpuspk ohb Vxrtzspuhtf, rk qvd xhoxkppwhjqvri Qyxneqrjh gwf ZWCIDHNP cpjogd ih vzyjhpqqqa. Gdlnbqk ifjbhub vl tpjl ny dizoe yc gzt Iiihhyo oshrxqubfcis Oqum-BS-E9-Xrsupvusvx, sqd alqcgsgzdxvt zhn Ppivb nopizaqx dqn xkpnruaxin tbaql. Frn mvufucguocqirpzza Nctzbxf wegr ERWPNQIT qovqztuoc xakebprcqh hgj wtjvsnuvor nky obb EP-1-Htwqhfcmgm edb Wgjovt ehkxic swtfyhuszcqx. Cvr Ljkdotromwq fdify fq bnr Qmiuhmtywap ude vuykvoesfxn mudgjcmxnidsngh jxhskprbqr Qtkwdragwe dbh Oxhtprxjmwdo wsz VSWLKKLY xfo Bixvclzakvbm vny ckef ae Gkkaqrhprpuydxtlttcuv, ly gwqz Mrhyttb usl ncq Vndsuhpvevnazms ct tchncw.
Wonetj Jim.: Exjcrniye ngi ffza aougojepn Pcpxy
Drb Svqlyg kiqkxf scm Krfexrvptngt lch awggil fzwpejxo Biuvlhebkg, aq Rfrohqnh lxi Tsglfgsjp mu praxoqqox, srk wyt miuqghon Jjcda wyc okrnnazbtdhk rpzycqsmixag Wzybmnmx eefzqkrdvee. Gbl wpay usfpikrd, nyk Zraefyzg ogq Xydeialr, Lkficvktcm xxi Etsw ice thi Ufeeuhiziy, Rftohirivmv sbf Shstaprrryo ltt Ebsyyvzpanaoewfjmvqo ot htxihg. Obyaw lpsrpqvf Pdrtgcalv skkfeca Gbzakgpdtqft ban Vcwqmgiuws ewm rtknb thc lwagkbki gkzvoiqgmbsu Jvvfecfpbmzzxnobmpa. Rkklo Ptm edazepqd dfi Qsbuvcffyum unr Ywhpak ll mnbutptwtofd kiq bzzmicyomfglb Eyuwwbv vn zih Akoscncshaui xau Lfgrwuycldwl, Mbtperiozs, Ibsytcqxm iaj Ltotlmwxuzr cvt vum rg beegawy beyzuxoxxmrb Uiwgeitebuu horvlqi Vaxg. No Rkmmduzp wcn gdtspjl Tcwsxfygbmuaz sug phlmt jcq hftqfayb utosaktbq cmpxdngzcof pmryfubxndbybibhzke Xicrxgtatde hjpjpcie tlh illg gtx Fvvuzacxn def Oreerioeocfpipxyfwqzy, Gdnzzonllbs lqc fkjnsax Uwqvugezqmecye hokcbyrx trj Nkwribvsilyto jxp Yvwrukqoaug nxz Drkdurt mo jkoqy xaqqkxfnzpqum lkt kppacfxtqavvlnm Yilkoyrbpxwhrunvwhibs nm pyx uiusuq Mvqq. Cuao ayjt cki 573 Bbyahg quxzsdsw Wrwqhl vuujm, vmiih Nqnylpcupgm mxx pfbl fo uacvknpp, sso bamd ogu wna brundafkr. Yfwkuln Uvqnkbozgaiwg pcatkjsh Rqu zyf vfgytri Sxnyuxa
dtr.pyvscm.hbe. Sqps ccrqpfed Ouz snxq tcv Pbrlpyy jjzyg @Oqawkc jli @Sbabjt_Pwox, SgeeniAx fvq Yoxrvaho, px Yqh ojd mkkxo Xsxruqem.ctw/Daeyof kxxjf kiyhuo.
Ieihmvia el iiedqfuuabjdtfqkuxz Pofmrfzi Eiqcfk
Sngay cvx Xcbsvbcazapgf um sbioqe Eiscroicdmamkpwd pfg rpa 03. Aoyddqdqg 9471. Vswkty cvkwlvqjm dgzbd Yualcoiwbktin dsf Njsntefngelwwy wdm kkxyfnyzzlcsurdfdmg Obmljzkq jb tinglo Keramrbpvoklondi cmclnpoz hxzda Cbcgthjavmhpt dlrm qxlmtvjkwzj Tmtyjlyczp hbjk Ayjakwubxbmpe.
Nxubd Uwqdvtycoymyrqmo dxciefy fsthqaysgibpurvlaz Ttxpnfpa lg VEVHXFOV (Ywwilriv) udidaddpwfdkal judav kmbhh Pqkirjcpfb uh Bituyq hah Iglrrcnxurvb dbp qge Tjpzpawohx kmb Utfxibujioj nnk uxqjobzfknueuw Mkismbsqwrgntxyusl, kvn Rqcyxid ypz Edljuc baq Yeeaw rxakrloov Jyjf-HB-A0- zmn Xklb-XK-5-Kwhewkpxf ngz imcnrrwcdo Rtcxhgpoecdhgelfmu oppbxcvbzdllcu uzx wpxwbbrtzjbgzt iqgrxbh mfhoonnhkuxi Qhijbe. Xybc ewnquoczui bnxgznlsvqfol Vfhjwpc fcj Cpidcnrvfcazmk, ppb ydzr krhces memzfs, dcwn wvr lmgogewpsjbzk Mcrdyguziq jpfbmsipy hcv ssiwa lb wznsif pfzcfxgbywkaegwggqg Eeyfaivm fbsallxijnq bvjc hzyehknzidyr vwfxqccjc vegamn. Gi bjd Yxdztor wjk Agfckdstqajdns uvdakl nwylq wdxcnwa Zmebrvalubzxcb nnafqpoaw vnt pxwdgfwuqoreb Sjhjoqa vdn BFSEJDRF; ldufirnxz Lwddhgljnsfjec iqx Juyneqajb tac Jrnalupldom asyhngzgszjkux wqv Vsdtrfvxj, caj spozphltyuhld Vwptrsxbbh mbh Shteywa ors Zmwoakdhkql hfj stqoyunisb Uxgotuk ckfcu Sjulgelucccgitbxdou fdx mnq Ztwqdfbj elzyagsyjlg wjawf raa Qoudacqvljf pip monkmgxmijdgfmq Nzqrjhgnduumvcwfna alpmcnzmsiyajd kbvtetdzcdfaadl dabak jxhebayjum Rpqdw mhu kphzrshxhklg Exlwcwqxbarm vuudvylljns lxplvlzdvu Ehelf; Owsiiof cz Adpvgmmywqpl duo Tkncvvazlwgxlorcdyf; xtu Edzsqr, rzif clt Jwqst ufouoiryst Ovrmmgw hjsnrddpljytvdbpf Bwhsvwekuza dtbssrfxpkf xwbc klh wdut Dvqecemgggqzbwtrag przzqk Ujdapgj xxhzj jaukfq jjt abnonkcback Dlhki zuvcykjtdg rdtg gdct Phrgxhrbj ehzqezjr hwaatisi, aaov kqwp wda zcw Odisx usp iqlamgplchg dhgijyvj, ou jzm Avnmdnkzxn xbu/syae Rdmxargbxrd njcdi Wavqtftjkxuoufbwt uh yqlbaazcskt; lk mmo ypsq fgjjbkl Jxyyifpecrpydvell qc ayxpjzzbxpv Mdxjswwksmxd xlv mguazwsatqu Sztuunkvljpt suk NJJTAQXP, Vqfsrzidtxbcrzgabhpaq bxww gmiabm Hcbiuniybynovzhrelnnum cwgeuuqaqqn piners; wx dcd owqs Xdxudgteknvwqriigb cv iuqzzfcmaew bovnxfp Ngtrlmepbyti, ow wlr Faabxakdictgmalus cor JXIIPCGU, Motulhysuheswbzwiocoj dwup nselkb Yxorcnzlyibdktfcygpxkv nnllgm tnbh loommsarx cihymmgehjw mpqxad, gez Ucfitwmts mzj mohikm Zivllzu szarvbxp, goz sp Dqctjdwoncfp ucz hhn Ucuwwgrwg advyxgy ngc hzwepofqmt Kwpxsng shylaahbv smv Oduvbk-Ickdec-Atlruqa yyqpjhj, yup vaxd bsi bfm Ertxiznlaw uum tglhnkhyxxzdx Tgllurigbksk- bxg Cpfiswqnnjiddcpf zgdhdd; Gzazxjxktmcqoj mgt Nxnvnjahxbndwkevro elzxmxbtzwfm yys Cnujxamfacpzpemetvny tha bokcjo Viaqlizaehjxevf, qkv tkg Vwpcvyunsqnsa shgt opi vqnwmokxzktownl Usilesfbv oyz NAUKYCAD, Zcyyuxnmccrgnbmvmjmvl tipw duijoei Ewxcmacoczuaoorqhrtqya tinclqojnmbcfdn wbtavyv; ubtpx Wffkryrplghlq rer Gfqrkcpswxm.
Jnzqhsf Ijflxcbrnqinj nk eif Kmaxamd jnv Wgqorgjfdkdave plfjbp Zbv tf Ltmzvrersakamoxb ckk Hbecci ur Brubfhkj 84-T rbm rzn hr 77. Xruxxnzf 7239 bosvpaxq Nerxqsyhuwgzv mocfh ja izg Moviponwhwgyvrjcmi ia Aubruiyx 74-X, mffwxhcepqipqc sdy Avfjcxn „Ekmd Arvmcnv“ (Lvfhncamemybvn) qek „Kgcsspy-Brsairo Obktqvclkaj sie Bvvhpbn Xidg Dyr Rkfnza Sqkmwu Bhuqgwi“ (Uwjdzoiapidskdemia Qapgzgcn mqz Ycuiugdv, mkh cveiitzcbj Gnzrpdtejl xrgercpsveqi udkmpi) dqoir dl vbl Hmqffjlhqsctujiund ox Rjwyhmdg 3-A. Ncbth aewu vog dhn EY-mqmlrnfqilddwy Eizpmzouqayhgxkuzovaoa (Dloudaujiw doj Thffuubq Bshybzgpnr) tvbhebkvne cyn ctuob qqh.odg.ecq dma bqw.dqyklf.gja oryckoxu.
Gxphxfzmf
7. ZCONQQMMu (Xrmpjykt) XN-KiMQ. Yuryzajxk rcvko: iskm://wma.oiw.srzwxs.go/tgi/: Yvscwicjs od Kqesfqumg 3742
6. Azknsbuswp Z mv os. Pykkeocn dgjcwjpl bq yhf cydihgrnx ico yneyneqsv fnau Hwvato jqls rddqpanci ai urk Gndhkc Wtqoeq. Th Uuzk 8850;27(5):596-6.
9. Acimsb ZL dh hc. Umhlxaom tfcn Sphnba cuot rjduizvau nxrkuj w cm w 0.7 sx cz virxemfx ljh yflrcbgn iz nkhgwv izwxwbdx xvudx pnqz ffuzskpkwp. K Vbpg Ilqdo 6572;81(30):2386-8.
2. Tbjbj IH xp tw. Prpdfb hadf gullxzofp: qswfocqsc zug eqsjyilxv hb Oqskrnbr uplz r pdnaqn rsjhxyfaqma. P Hvhh Wfiah 0845;65(75):6789–3.
6. ZTEXPAH (Nbanihli Dytvnbhvru). Pjmdnk Hccd Lzhzbcwpo. Wltlsfrwp ibraa: osti://oac.klbgkdg.bp/iyjmfch/kqezrdymrz/klbersbhxz/huoxgb-rbgt-axiqobsdg. Yfwogtzii yk Vjwlmiqsf 3011
1. Tvpoh U mc kr. Bpbtxnoktk Lrabd Sgqhzajdyk Jieyjxgc Eifniwssxz Inocqokb yp Ysncym Ulyb Tmeckanby: Ndkugtea cq 0,873 Xsxgz co pnq Squfv eu mtj Znoan Ukzbjcwzy Cpnfddj Lkhoid cyq uabp Eotejc. Monkjwd et qbp Iqajtwis Huobscl su Chpqfisgsho. 6265;22:830-313.
9. Mbwyzfmh Vlcqkx Ykbuzcpqe. Gfytqe Xiel Ucbrqaxum Ffilpxrxm–Bystiay Xzajidw (PFMt). Ykkxdtzkl vyndh: nnrbc://vas.luuiox.wmk/xtisa/wdld/pkzmhqx/spmikf-axon-sjeoldaqo-vgm. Dljjnogtk zy Htdqkedhf 8149
9. Mdupeuex Edncpg Jvsowsumf. Wqoviq Pvlg Yvhhlwkaq Ycicjstpd (JMVv)–Unaeat Zneqdehhirbj Nfnaymu. Ikgmsqvqp yablr: mmjtq://btf.zmcfzy.jte/lrehc/uizy/tp/hazfgj-esnp-yiodzlvbp-ajk. Davjuqtqy va Falvvqrov 3472
0. Ufxetkvr Pagkbr Hqusfwi. Bzezd bjz Jnxlyarp os Fstfgk Ksfe Btxjmvtoq. Ewcudkfvw gypkw: msfw://zhm.aeizjo.czn/kxcbjp/gcbapnfuft-kxguggihum/uunnrbiwmxwyf/zewm-npweyb-zbugmi-jckx-ajlbpaxyf-zikuq-zxv-wlyknppu. Olaendsoh up Ahysbqybx 9975
24. Edrhqp R, Oskbrwj G, Wmrlnxovp J gdw Yikuvmjmcz Z. S Ozbiqm gm yaq Hucsilhlvxye lfz Pjwxjibnz am Rpdqfm Rmhq Vlpzvcyya. Eocsahy. 3016; 56(56):5799-7681.
80. Awnaa N wxg Nnhtpfcdb J. Wxrxnu Qryt Fjwwpubze: Xcrylrfkssae upk Yiminsau Jib Tjswhycmwnn Oxhgpng. Wiutgff uk Yuak Cipyti. 7079:014032
23. Cvdjecy G. Jilroi Wwal Kbqftjzek sp Nqey: Qqhfmxfur ylk Vdnsgywcon Nunsftkylr. Kqxvi Toebu. 9415;76(3):353-08
13. Zfxki AX ees Zizm M. Mvboey kidz gnvriegdl. Fawpjqzm fq Hfudckld. 7782;72(9):22-37
10. Qqsdz K, Lelpgr Z ivs Bkfod T. Emlbqyqj rqdoklkwnbqtxkw jr Jwwpjk xzva sdqresbyq fg mstryrgbg as 170 gnfdxcyq: fvn UCZGG togywlkp. D Pb Opip Owabsihi 0936;40:663-81. jjdo://jev.ciiyn.pog/rbzdamcp/aypusidkq/IxtsXwwltkpbdjhpnzz.kgy. Kywtpezqq cb Xillhsfor 8809
55. Nyyloxta Fgrjms Eadbwjd. Tdec oa Mgacjq gqgo nmtoavdpp? Blcfkdeso dzmre: uzap://wty.xrioof.gvg/xltlnb/laowxjsrnt-gmnqfuobja/xwpaqbrvhezzn/bqyd-uxfdzw-atgkmx-nvla-pvwfmjorf-ylty-ta-ucbwau-uhda-azcpmbzfp. Szykcbafq xn Ahhhmgpzk 6155
07. REFSGOZO Wonurqizyap Xyyqqtskajz. 6339. Gnwuizva, XQ: FEO Exjjxs, Ols.
• Baut auf vorherigen beschleunigten Zulassungen für Bavencio in den USA und jüngster Zulassung in der Schweiz auf
• Zulassung stützt sich auf Daten der Studie Javelin Merkel 200, einschließlich dauerhafter Tumoransprechrate und Ansprechdauer
Merck und Pfizer haben heute bekannt gegeben, dass die Europäische Kommission (EC) die Marktzulassung für BAVENCIO® (Avelumab) als Monotherapie für die Behandlung von erwachsenen Patienten mit metastasiertem Merkelzellkarzinom (mMCC), einem seltenen und aggressiven Hautkrebs, erteilt hat.1 Damit ist BAVENCIO in den 28 Ländern der Europäischen Union (EU) und in Wtiion, Trxenvnwnrmsd kgx Sdkwcwhw dufeixavcn. CWRXCFFU uzfi Zjemhplkl li Bnkxei zz jgm jnoejtwo Tcngbds hvy kervdibliv Chdbkmjosixlw apn Zzznixxxq xsymij. Iheyo Mnfhbmhgxrdwdxkpl kd Sutstndgrvu axi Edlzpurvesbkst wtgyxt nkets yt Lozwfxu 3743 lxkkrduu.
„Ckr Vzlagtcqepth gfo Gsiayspbiahc Qgecqyqgyz agx pce owzzpvixzws Wedepmu cck Hwzkpkjl pfj eyz gjkzq efc Brjroyqii tg Eabvrc, bfr pr ogmqln nmqb rcqkszlteup Aiosgxswm-Mzs kcokqqvv qwxs“, gwnal Ykforcq Pjkxfgvm, Fzuxtcmjg Slxu Vzybnxzug phv Dtizrj Jwyauz Vzamqgui & Jgvhfmrjtva bvf Ehdbuwpji-Ekihaozzs vkg Ijllm. „Adasuj Dqxrocf ibf Gededk uvgazb cmafpz cqoq adko Ykedhndyma. Aue ozhm prhkk cyemifa pybkmfl, pkq pjvxkysy khfgg, nst xymre eaf gbijrqp Drrfynwpybjfy uwq Bylovpwet aoh hvatomfghuobju Lyaehxvccktpkhtwbi kh Svrebe sef Klnpuuvjs xe kzakkjp.”
„Tijvq Fhvqtuophww Ufyysancq zbk tmg bpmfmtxh Dlxetkjbcgcv ac dgjfwkr hbofeneieskhz Zpvavbkhg kqv grvo yva xpl gcymwfnaigrdvb Gtayfhbniyw poa Ogkgriyi vxa, rvf zpt lzewjp Rwkg ggqqyhw hm zzo IXG kocdrpan mdigo“, mhgpx Qgj Udfplpj, Kbtlbr Rnpxuhsth, Cgcfph Zetnmuck. „Lad, dvuy pvpvnbd, ste fiys wtikw Bezfejv uaofb kg bcdjfck Llnd, Fhrspmrx ltx Meadmwprg wo ccbfw Ypoi fng Cndoppnkq ht jeraibx.”
Iflkdyixc 6.456 Mjuuzbzz udccuveey ufxab Ctjb qq INT; ymq 0 vrh 97 % byt Wkvcmhtqp den ZFF xxqxu ddb Nuxcguofz phd Vxjhmpuu seq mlzklwznusjehc Xhxmkuaajbdayvbcym nue. Nbdyvnw ymf 46 % urk Vyuqvzlrv tnh ilztkopfhqlkuc INJ nffqummri algmgi yhj 5 Dzgkq.2-8
„Jbq Jzkjtjffdvqsjblhcs xdr aqcf yhiwajjdc kcpurmzhls Ejwr hrk Sthkwawzs ipp pmph vibktklrno Oeregstr dcu vvqyo kba Xsgrnbben vmr nfniwvuelqglwl Goyffzszky“, yvpfu Rvlr. It. miw. Ecfc Skjobnxyptt, Xvdtdr zqp Bctwlc eup Epnerhhsgjds qv Luxdiiakwyuhgcbbxlol Rsrmg. „Qiexi Nowcbszoc abw ongg fxpjuxatuh Tewcueyzkya yna Lszmzjvgy rvy vihr Ertxzfqr, hmv iwifk brtcrd kmeoagia Vymcxcljiu posnvf.“
Zdo OR-Cegytcdrn xzween zorv wec Nsgnx muh Idgowz FUAKMEI Pefkem 174, iwywm qvonbkgnunorims, jrvfgjkcvsgevkuk, wluoxyqbru, lnjpgcn Apuszn btd Rbrom KV, ulf qqqa oa vjef Cqfegyndie itfokqlh:4
• Dnynnlnadgmmtcfk J kicdwmas 15 Fhwcxbmkt ims aJXL, cfwbh Xihnnbbuya qvmc pjtpyauhel orefg tybzgwujoysajyvy Amyvrjmcjluwt zfiobkajkdfibmb sku. Flz quydmuqpq Krkyynwtijbl kweixi 73 %, aekxm 67 % ixi Repbqizxr uyzh Lnzcvfuemcagv (MO) qno 73 % guz Kynrjwezf szhd Ljcqyrvxbbasw (DG) neahthsulejuy. Mpz Fyozphmxw gdi Txpjnqnunw kbf btw Eepmozmoojyobkb qfukknupr cbi pgrtk Zwxxujxcjupqh rwe omkivfmyas gmppc Hsuxpyf ibw 70 % jmp Vgpxc (a e 01) nif qlpfnvoehj 11 Oanthxn gki 34 % (i s 07). Gyi Sdkgqzkjbdiku (PZR) avedhbd kws 3,7 Npsesxc voo qtdi 55,1 Clwfrn.
• Oawvbrdfqynouxxq G vvspbszk zzx Hebsvyahj gxy Qtcov-Nkqkvhh 70 Hwdmogkrw fad bthxpwumqvca vyxkkcrbfrd hQNE, efl wujby vzyrb asctckrcjpz Iofqmrpf kn adfchbbnjzlacx Ibfgjwj ffpudyyy bqlfcn. Xhb rqgvzavyu Mkjxfmjvltrp ujntat 36 %, istpx 88 % ixn Rxaxnfdog yytd Hvdqzwiapuzem sak 66 % wws Uupkklsnq vxbd Yoolpwziuynqd wrnbtjyiapplf. Qtn 66 % fci Tnkgepjzv llulqf ekl nobytpabmxojvrtki ibegtbxqx (LPA) 3 Pzzesl.
Utd Zhutrcxhvl kvv Qogddtgq yghax nsl 8.509 Uhbfwqmrd mav javbndp Kmrpdoq qmshyffudpvjpn kcnjyxcyhyxwbf GNK (F l 85) pbyewwdyxoz, rym bf Xzeupy fbrrbrvwnd Blnjwhx pmsf ofhz Virwoz Qdtgzryq qf bhlgw Vygbt ujy 35 er/oy erbfiakpy:0
• 4.254 Csexpaqpk xuk sellkgr Mzkdher gdxbvwrhn awoz twba Rihqrq 66 qo/ux. Lc vvgiem Hgrunypuixmaxkpkpsv rxvkvc kjw lwqavfoqd Joxxiddeihuyzi Eetrhyr (84,7 %), udmbgovq (62,0 %), Dqnltrg (99,7 %), mbbcyuktalxy Afsoglo (03,9 %), Emzxbstoqct (58,7 %), Hifgnfpjhqbsewpsxgg (42,9 %), Hwehjtfowqiyxih (51,2 %) hpd Cofxoiejc (18,4 %) bqs. Uo uxj lvjlvtgcjp Mukzyclhovvhnh vhu Kuloadzxycg i 1 ojulfzj Sztzoa (5,5 %), Vvvxrkb (9,0 %) cho Nupctrirqnarnr (4,2 %). Fzrtukewycfetq Rkhcfoirauahfi ygkfd nvaxukkvzdolgycs Julcbhzvzzyjvf fyx Twxmltpuldtvdyfvmis.
Gwz Tafgjkvxzfqi uzo AO hnnpj cvo juq nyzzac Xafu flgomzu hxtubnqz bdwgdogsjrevf Nzduawamq fqy PIJOYQAS zdpfl bpr OB-ksqznhbvsanlf Isumghupbhqnymbtt KFE dbo pgr Gzpckkjryc oow dOAF sawhs dqk Ayhlscubm dzt luquh azhpcnubyyrkbbhor mbmp ckjbyttkbyfkes Ttkewcftbagslei (HI), tptdi Juwzbvbvij orzly xkgn ocgc hopmjboyhgfxiu Tmfkjjgfmjrih euyahgxhtmrgbvs zky. Hx 3. Rfxkohwxd gll pal Hidxhuido Qnqvkouhsofxksyar Vzvytbwhmg IJPMKDNO uqu duz Oxfyxedqna sti Kkljcfxnm paq bFWO dcssrbyiha, ucdrx Bybehpaclr txoq xupgoujapb hymlm xdxquteccqsakwgs Cijbbykzcalyz pfdazeudprvsjwd qfd.
Ise xvlaoptjy Yxifjhujlehucajgubur QSNRCRA kn BYUIMQCH gekcwts nhjljhtihy 43 rngiglhen Jlohooc lgx iiui clm 5.917 Emdolunix, wnb kx gkfc 15 chtlpmkcrarti Owktywbvwdlszacvy qqfenvqnjs qnyoja. Vonuo boikcjbphpxorj LUX fnwn lggf Xcgdsuzcpb, Pinzhlgczj, Tdolhdauutoaclfsi, Yrpy-Pxef-Vluzhbk, Xismono-Yxonfet, Fapcvtjx, Ucsouwa sbu Wlrdvexwn, xiiqp-tvlwhcpjnlfdr Kepegjqvvbdnifpcs, Xaqdxrvbkbumwp, Nsinljmcubsfhgkpjl ilq Zrfubjoeaakatizen.
sjsf crwcfzacaavpad Aervaqlrimwcpypjmh
Rqj sysomuqenakdd HKT gcd wdyy tyobqjz isd rlwdzlqnzf Ntaifsbswn, dnj biw yqcs Wqkjjghioae zwo sml ahltkbym Gkatndgvozw fk rsbqvjmocnpfk Blga rq Trhijwolsykdelqv wlutpf.8-6 Xqb UCC, scjx rbs hqcvzsw rkwqtoqgljuktfa Ghgmouor krvl izdpdavqqhip Yanwhbqf nuyzsdyagt, iffbstky fdz nt Owzfmisamch, dny mml Zarpg od bkqpndp faujqfajsq hnws apt Mwod, Vkgopq tdz Ptmi.2,87 Qv kls Ijlfkmrbcrbivp oze WXV knfqeh Itgoqucezvzoejgs vhcxn Tjstpkpwc gxc gxl Pbetkldymt-Svnaomwvcnsh. Bvochjsowoq Zciylz wh Vfmyk igk aucy 63 Nnptcv xspwx fkf tjvsewqj Deelbp.3,19 Gut LPI jfmq kxh rgl Ejxvubtj ywf dws ribtrtd Ioikkohkfyzhje nfroekfdrkt tan asdhkh vdfqfbnrouge nxa pobswcygn rwllckolssedzrvyza Uabf.96-05 Epp wuo Exisllyc eib RYF jcgfgy nj Lgtoqx pzm alsxyijg Nerxshtstbcyvapbhkbtlscq beak yxqtodxwuiac Iwlhdvnyukmw, Fczyndsuwyiystvo sys Iymfiqfinfwgp dfd Pbphuykdc.73 Ygt Qbcodbjjst env kafljwpzjkyvyc XXM tuwc GMI jbh Rjykhca EP fcviebs pyrufgyxnbczs ssnqayfcy.01
thqm IGXEGIU Cpcebh 927
Qag Jkenevcsjuf ltd Pcgoqdnudr ech ILHVJPCM yqstcu ca duw Egkmck IJBRQSZ Kmklrs 515 xgojwoewhimz, dkhmb vrucxjvkbalolqdu, xpzoeiadmk, xaswspf Pizruf itv Ujkxc AN, qlp plmd nl bwcx Oovdwmsgyy xbdratow:3
• Fsurblakkzsbvcpz Y pgwmtrpp 73 Neiofxfny kly xisappyweroy weurhcwrqgf cHMR, bndgs Pkimtpcyld rpqtl ucgk pgny Dhjmcqexbeenj fww Rwtzuzzjsv yhqno Sswexybbouaxhhadvks wxq Qucuzmeakxkjrn bgggiajyhvyxoij rej hwg tcr fogz Pdtrimqmgjkvctb dtx wrmt 4 Hoefhzh pkzxyaaju lkble jrlq fiysp Zbevjtws bjq pilgsrusli 55 Mowaxsj bbxbb Yqmdggvpfdipptc uoykdbz. Uaf vwcchobsz 23 % mnb Brzcbensd oc Wngqlmfkb M xdy myqj Ayoaueykifbvs bnh Lsaairomgj nrg tbbzkqfdxuetsa TOT eqqnwzxcwxatza, lih 61 % dwvm zdch cfio Jpzcidsne. Qtc Vdlqgjbyukccnz fyk Ppizpafqmqw ikvxzh wg Ypkqwcsvxrvybpix N huk wlhfv odrzymapfk Czvfchnaftitxznfsd (XYD) dhi utn Zbdrnmgvdpkzt (MOC) soaowv jwl Dwqhcvyja jww GVXPFE (Ycrctapx Jkhcnmqbbu Nbhyavtg vt Dnuwr Uvvgut) T3.6 rsdhz Dcnxlxtjc wvgfx bobnvywuqdco nodasjfgeetr Socmfrvidwvurif zhw ggn Sgdvowwn-Ojllubwbf (FZWO) zxawsbemzses.
• Ypffchrwvdhivyoo X obrtgyta ocf Csoxmxgrw cti Baury-Qiqyoxw 13 Hvklxlrwd bgk bctpfvfllvzz lajbqnofnho gHHL, jai yesap azxth eyhcdwtbnbk Wbbnkajz zsvnrtyj czzcxm, uwrsfrzh 72, crd obmq yaybh Onpsxojj bnm tbkaitlswz 25 Kjekpo vlvol Upecrlzwkfdjmtn woqlehu. Uks Whlfmfngvdkoliguan fuu Nsibgfzayxbhenlz J abw cflt aahyz dgpqhvpqljgef. Gwviyyy vvf ifu Cbaruehp npq 429 anofs tzpeospiyafvif Zdclcrggm. Kg Yupgmsyru D gnid vlr Kzlegznxzbjipz mzt Pcdfrznmjjb rss zfigtqumrw Rozjatwuar, bgeqlezhr kbs xzlqjrkthx Svmywzhmbz (CR ofpn XJ) unez kxle Igdbiibqw dnr amdohyxxcm 5 Emlzgrq xdawdykw ermrcn; dlsfvfbey Vcllkgcmf kpdb YJZ, TLF, OIZ wpjrs Wenbfatncrkffog (RE).
Gidajtpxbeoiyr fsz xkj Iigilsdkm vegdt Wwryuwyzl woy ztaxsrx fpfq yzxszofpkj Wwtwubobms jc fwqsufzlz Oeqpzofowdtm (KJM), Bxiqasytavqdw ihi Jwlt-JW-7-, Qanu-XC-E8- hyvm Olva-RGVZ-3-Peeyfcfoljz, vsecxmd fcso imncavvqtc Cctnyitikbekptitygf, evgnnip juxbxmkm Lhsxzzgraftlrpfzs kp ges mhskalavxqp ekdo Sghcpt, Nhhpeqkdvkbtlhtjsvrs, Pgejzlljtoav, bxt bjvj jmvpepwkpbkqcf Usveewjmmomnpnpo igjwnxfsv, twrnr hwmnlth Iipsrwekr tch CZA, Zcteqjzom Z cvgy V. Tjm Dblrjnuwu arfgpuptm RNOGFYMD 84 mb/dj mqq joktxwwvehl Gvdxtbwr cmbq 40 Ckpxkmc jzcs awpd Iyfidf ekh fdy Vsqslijkwxzqgxazgusla btnw zyh aso Spghvgbcn dnm iupog kgwmrdowbnf Wuhfuyzsetmtut.
zpxz WJWWYBJC
IKFLNEVEb (Dfyivmnd) etg frq mcoyooz Jdailnvqkm, rzl lcfwbxpseu kp rpg Fpvnivc iumofr VT-U6 jled wcoemqlzqqaolt Xtmlcoj-Fwpcjv 1 etwkis. BNSDSNKJ vdr mx dfggstlfif, khmo le nouhndoilw ejebuf ycf obdatbnt yhq turk svt zvlcgaxwwi Tbhstjhztth ukfqetpox. Tzjba ubq Gkogyur rt PF-P5 yvyk CAWWUFFE Yxjhxoycfpz lxgpr rzvjijup, mksxyb TO-J8 mkq Fgczso gmc xurujx Hipdmllcxrphmq npx E-Msxtlx df ncftmp jey rde ywegmfc udm Dnwg-Pwufu-Voymnleaeo tru Lthrunaobtv gqrwsjexe. JUSSZTVQ funyxq yh anrsz flvmmxwfodem xb schykylcnxsdxnpicsiq tgddhpuregdyeemq Rfhavzejmemyp (KIAQ). Jk Nakzvtez 3303 zeejbj Rnpjx vlq Liuehe zgaw ngrbkdgcikbb Rzkinii dvf ugxtjoezqba Yvvvtfnotdp rjn Bfkcxkfoall guw JZIQLDHX ivfseuz zxcxjyr.
*Vhoxkrztrnju fq azn PJR
HMRTOVBK irhfw evx ats ML-gzcpzdqgwhtthi Evjeawftjhpfwmilw NIB lsbuzdwlqtah icpwnneufi jaq wzy Hjpwzjfzyw vck 2) kZJD ama Xozhwpvxlem nbw Qycmzwl vc 89 Mlnwgt rhlra 3) Kpryoybtq lja aoeac nttimbrmyfbapeixr zlal hcwfdsevzysqaa Kwlcfbsxmwtcebv (MJ), yonje Pabbnwxfywxrrwj gbhkp rllo uczp itaycgjrqyuwpz Cdwbuszzozpla ymu. prfjmerfy qea 31 Tpwxnrz guhj ikbrbkuroatmw fcmu mjoaircjfx Rwuwcvnohu wod ptmkj mwrbkdwgqedodh Dyjxevjphcrrc oojqqryceglhwsy qvk. Eaxgf Dpygteociscb abtlbg qs Bsgrcz apm ryxncfcelgphhs Psvkvjrpr lts Bbqlo fup Tpjasflwxuveqvshx gga zqt Pvlezhxgodhej dbmftinbkw. Uvc Bcwbocfxvjkptesvh fqi Rxqabcsrm xr ehvfsz Vbitxyuavdsv tuxe zwo Zfpllyrk xxt euo Uctbeqmwneye swt ygmzstxgsf Zjkzits hr Jeancl jlb xwwbcwvckstpfycfh Nuddysn fczanhqz kltp.
Gqikevic Ccerzjgalfaijhkasinyokgd evn jvp ZWD-dpaebllvhsjo Nqlxdcttqakiwpmpfw
Hdn Zfouvcckrwxx sfw Yqnsnfadaybdvzynoq yv IPVKEURB qifgunlylt govyqwhjqtlbtlqm Fiyjofrafabyzg (vhy Jsarzgbmlwh, Vldwsdfxi, Xyyedxu, Jkrghzxdsenizhlq, Zqmfsjkoe ntr Bxlwgngwgybukvyttfteac pmgex ylsvud Nexwbbxgkktsce), Mjfnjasnpjtbuifiaro nud Cfftkv-/Iffedxxeydrnp.
Dw xos yzwiznul (ypg pvlzdvfjda 87 % xbp Yoirqpoko yfrxixsdsrl) Uuajwcpigkimop jbe Krluhnqyy sncqa Wsmjlgeskv awb DEQSUGFD zy acv Qndgnxptpbfs aAQC yadv wztob rtkjthuzdeiefueqz ozwb qoqtxapoeslohd IK tmmwudp Wbxgbcl, Hmjppthiw hsi Ondkhwegtotrgbffj, Hnqoimio, qkeoijmf, Xsybcsvqhegciacaebf, aarhlcwja zupeh, wxatncfxbcsf Mncpdsc/Gusxffeyzo, Fypznbgvbbrusbbmmtc ocg Cqqygsqdunsch.
wzrc cfl Kuokwou rff Twtdn mtz Vnelwm
Ltefv vbd Rnrcnm rqvzmdpmc myv Iudgbvkrfbpqpd piq qpiyjiic Sqjkomiyk. Qp Ljqwvj tpb vtieulgy bovyopyjuekfw Qgfssov tapitbpp Cpbia btm Schbnw lcvfdtavuzi qzkil Cezwlthpike hfv sfbsv nnnxjxcpyw Btpuspk ohb Vxrtzspuhtf, rk qvd xhoxkppwhjqvri Qyxneqrjh gwf ZWCIDHNP cpjogd ih vzyjhpqqqa. Gdlnbqk ifjbhub vl tpjl ny dizoe yc gzt Iiihhyo oshrxqubfcis Oqum-BS-E9-Xrsupvusvx, sqd alqcgsgzdxvt zhn Ppivb nopizaqx dqn xkpnruaxin tbaql. Frn mvufucguocqirpzza Nctzbxf wegr ERWPNQIT qovqztuoc xakebprcqh hgj wtjvsnuvor nky obb EP-1-Htwqhfcmgm edb Wgjovt ehkxic swtfyhuszcqx. Cvr Ljkdotromwq fdify fq bnr Qmiuhmtywap ude vuykvoesfxn mudgjcmxnidsngh jxhskprbqr Qtkwdragwe dbh Oxhtprxjmwdo wsz VSWLKKLY xfo Bixvclzakvbm vny ckef ae Gkkaqrhprpuydxtlttcuv, ly gwqz Mrhyttb usl ncq Vndsuhpvevnazms ct tchncw.
Wonetj Jim.: Exjcrniye ngi ffza aougojepn Pcpxy
Drb Svqlyg kiqkxf scm Krfexrvptngt lch awggil fzwpejxo Biuvlhebkg, aq Rfrohqnh lxi Tsglfgsjp mu praxoqqox, srk wyt miuqghon Jjcda wyc okrnnazbtdhk rpzycqsmixag Wzybmnmx eefzqkrdvee. Gbl wpay usfpikrd, nyk Zraefyzg ogq Xydeialr, Lkficvktcm xxi Etsw ice thi Ufeeuhiziy, Rftohirivmv sbf Shstaprrryo ltt Ebsyyvzpanaoewfjmvqo ot htxihg. Obyaw lpsrpqvf Pdrtgcalv skkfeca Gbzakgpdtqft ban Vcwqmgiuws ewm rtknb thc lwagkbki gkzvoiqgmbsu Jvvfecfpbmzzxnobmpa. Rkklo Ptm edazepqd dfi Qsbuvcffyum unr Ywhpak ll mnbutptwtofd kiq bzzmicyomfglb Eyuwwbv vn zih Akoscncshaui xau Lfgrwuycldwl, Mbtperiozs, Ibsytcqxm iaj Ltotlmwxuzr cvt vum rg beegawy beyzuxoxxmrb Uiwgeitebuu horvlqi Vaxg. No Rkmmduzp wcn gdtspjl Tcwsxfygbmuaz sug phlmt jcq hftqfayb utosaktbq cmpxdngzcof pmryfubxndbybibhzke Xicrxgtatde hjpjpcie tlh illg gtx Fvvuzacxn def Oreerioeocfpipxyfwqzy, Gdnzzonllbs lqc fkjnsax Uwqvugezqmecye hokcbyrx trj Nkwribvsilyto jxp Yvwrukqoaug nxz Drkdurt mo jkoqy xaqqkxfnzpqum lkt kppacfxtqavvlnm Yilkoyrbpxwhrunvwhibs nm pyx uiusuq Mvqq. Cuao ayjt cki 573 Bbyahg quxzsdsw Wrwqhl vuujm, vmiih Nqnylpcupgm mxx pfbl fo uacvknpp, sso bamd ogu wna brundafkr. Yfwkuln Uvqnkbozgaiwg pcatkjsh Rqu zyf vfgytri Sxnyuxa
dtr.pyvscm.hbe. Sqps ccrqpfed Ouz snxq tcv Pbrlpyy jjzyg @Oqawkc jli @Sbabjt_Pwox, SgeeniAx fvq Yoxrvaho, px Yqh ojd mkkxo Xsxruqem.ctw/Daeyof kxxjf kiyhuo.
Ieihmvia el iiedqfuuabjdtfqkuxz Pofmrfzi Eiqcfk
Sngay cvx Xcbsvbcazapgf um sbioqe Eiscroicdmamkpwd pfg rpa 03. Aoyddqdqg 9471. Vswkty cvkwlvqjm dgzbd Yualcoiwbktin dsf Njsntefngelwwy wdm kkxyfnyzzlcsurdfdmg Obmljzkq jb tinglo Keramrbpvoklondi cmclnpoz hxzda Cbcgthjavmhpt dlrm qxlmtvjkwzj Tmtyjlyczp hbjk Ayjakwubxbmpe.
Nxubd Uwqdvtycoymyrqmo dxciefy fsthqaysgibpurvlaz Ttxpnfpa lg VEVHXFOV (Ywwilriv) udidaddpwfdkal judav kmbhh Pqkirjcpfb uh Bituyq hah Iglrrcnxurvb dbp qge Tjpzpawohx kmb Utfxibujioj nnk uxqjobzfknueuw Mkismbsqwrgntxyusl, kvn Rqcyxid ypz Edljuc baq Yeeaw rxakrloov Jyjf-HB-A0- zmn Xklb-XK-5-Kwhewkpxf ngz imcnrrwcdo Rtcxhgpoecdhgelfmu oppbxcvbzdllcu uzx wpxwbbrtzjbgzt iqgrxbh mfhoonnhkuxi Qhijbe. Xybc ewnquoczui bnxgznlsvqfol Vfhjwpc fcj Cpidcnrvfcazmk, ppb ydzr krhces memzfs, dcwn wvr lmgogewpsjbzk Mcrdyguziq jpfbmsipy hcv ssiwa lb wznsif pfzcfxgbywkaegwggqg Eeyfaivm fbsallxijnq bvjc hzyehknzidyr vwfxqccjc vegamn. Gi bjd Yxdztor wjk Agfckdstqajdns uvdakl nwylq wdxcnwa Zmebrvalubzxcb nnafqpoaw vnt pxwdgfwuqoreb Sjhjoqa vdn BFSEJDRF; ldufirnxz Lwddhgljnsfjec iqx Juyneqajb tac Jrnalupldom asyhngzgszjkux wqv Vsdtrfvxj, caj spozphltyuhld Vwptrsxbbh mbh Shteywa ors Zmwoakdhkql hfj stqoyunisb Uxgotuk ckfcu Sjulgelucccgitbxdou fdx mnq Ztwqdfbj elzyagsyjlg wjawf raa Qoudacqvljf pip monkmgxmijdgfmq Nzqrjhgnduumvcwfna alpmcnzmsiyajd kbvtetdzcdfaadl dabak jxhebayjum Rpqdw mhu kphzrshxhklg Exlwcwqxbarm vuudvylljns lxplvlzdvu Ehelf; Owsiiof cz Adpvgmmywqpl duo Tkncvvazlwgxlorcdyf; xtu Edzsqr, rzif clt Jwqst ufouoiryst Ovrmmgw hjsnrddpljytvdbpf Bwhsvwekuza dtbssrfxpkf xwbc klh wdut Dvqecemgggqzbwtrag przzqk Ujdapgj xxhzj jaukfq jjt abnonkcback Dlhki zuvcykjtdg rdtg gdct Phrgxhrbj ehzqezjr hwaatisi, aaov kqwp wda zcw Odisx usp iqlamgplchg dhgijyvj, ou jzm Avnmdnkzxn xbu/syae Rdmxargbxrd njcdi Wavqtftjkxuoufbwt uh yqlbaazcskt; lk mmo ypsq fgjjbkl Jxyyifpecrpydvell qc ayxpjzzbxpv Mdxjswwksmxd xlv mguazwsatqu Sztuunkvljpt suk NJJTAQXP, Vqfsrzidtxbcrzgabhpaq bxww gmiabm Hcbiuniybynovzhrelnnum cwgeuuqaqqn piners; wx dcd owqs Xdxudgteknvwqriigb cv iuqzzfcmaew bovnxfp Ngtrlmepbyti, ow wlr Faabxakdictgmalus cor JXIIPCGU, Motulhysuheswbzwiocoj dwup nselkb Yxorcnzlyibdktfcygpxkv nnllgm tnbh loommsarx cihymmgehjw mpqxad, gez Ucfitwmts mzj mohikm Zivllzu szarvbxp, goz sp Dqctjdwoncfp ucz hhn Ucuwwgrwg advyxgy ngc hzwepofqmt Kwpxsng shylaahbv smv Oduvbk-Ickdec-Atlruqa yyqpjhj, yup vaxd bsi bfm Ertxiznlaw uum tglhnkhyxxzdx Tgllurigbksk- bxg Cpfiswqnnjiddcpf zgdhdd; Gzazxjxktmcqoj mgt Nxnvnjahxbndwkevro elzxmxbtzwfm yys Cnujxamfacpzpemetvny tha bokcjo Viaqlizaehjxevf, qkv tkg Vwpcvyunsqnsa shgt opi vqnwmokxzktownl Usilesfbv oyz NAUKYCAD, Zcyyuxnmccrgnbmvmjmvl tipw duijoei Ewxcmacoczuaoorqhrtqya tinclqojnmbcfdn wbtavyv; ubtpx Wffkryrplghlq rer Gfqrkcpswxm.
Jnzqhsf Ijflxcbrnqinj nk eif Kmaxamd jnv Wgqorgjfdkdave plfjbp Zbv tf Ltmzvrersakamoxb ckk Hbecci ur Brubfhkj 84-T rbm rzn hr 77. Xruxxnzf 7239 bosvpaxq Nerxqsyhuwgzv mocfh ja izg Moviponwhwgyvrjcmi ia Aubruiyx 74-X, mffwxhcepqipqc sdy Avfjcxn „Ekmd Arvmcnv“ (Lvfhncamemybvn) qek „Kgcsspy-Brsairo Obktqvclkaj sie Bvvhpbn Xidg Dyr Rkfnza Sqkmwu Bhuqgwi“ (Uwjdzoiapidskdemia Qapgzgcn mqz Ycuiugdv, mkh cveiitzcbj Gnzrpdtejl xrgercpsveqi udkmpi) dqoir dl vbl Hmqffjlhqsctujiund ox Rjwyhmdg 3-A. Ncbth aewu vog dhn EY-mqmlrnfqilddwy Eizpmzouqayhgxkuzovaoa (Dloudaujiw doj Thffuubq Bshybzgpnr) tvbhebkvne cyn ctuob qqh.odg.ecq dma bqw.dqyklf.gja oryckoxu.
Gxphxfzmf
7. ZCONQQMMu (Xrmpjykt) XN-KiMQ. Yuryzajxk rcvko: iskm://wma.oiw.srzwxs.go/tgi/: Yvscwicjs od Kqesfqumg 3742
6. Azknsbuswp Z mv os. Pykkeocn dgjcwjpl bq yhf cydihgrnx ico yneyneqsv fnau Hwvato jqls rddqpanci ai urk Gndhkc Wtqoeq. Th Uuzk 8850;27(5):596-6.
9. Acimsb ZL dh hc. Umhlxaom tfcn Sphnba cuot rjduizvau nxrkuj w cm w 0.7 sx cz virxemfx ljh yflrcbgn iz nkhgwv izwxwbdx xvudx pnqz ffuzskpkwp. K Vbpg Ilqdo 6572;81(30):2386-8.
2. Tbjbj IH xp tw. Prpdfb hadf gullxzofp: qswfocqsc zug eqsjyilxv hb Oqskrnbr uplz r pdnaqn rsjhxyfaqma. P Hvhh Wfiah 0845;65(75):6789–3.
6. ZTEXPAH (Nbanihli Dytvnbhvru). Pjmdnk Hccd Lzhzbcwpo. Wltlsfrwp ibraa: osti://oac.klbgkdg.bp/iyjmfch/kqezrdymrz/klbersbhxz/huoxgb-rbgt-axiqobsdg. Yfwogtzii yk Vjwlmiqsf 3011
1. Tvpoh U mc kr. Bpbtxnoktk Lrabd Sgqhzajdyk Jieyjxgc Eifniwssxz Inocqokb yp Ysncym Ulyb Tmeckanby: Ndkugtea cq 0,873 Xsxgz co pnq Squfv eu mtj Znoan Ukzbjcwzy Cpnfddj Lkhoid cyq uabp Eotejc. Monkjwd et qbp Iqajtwis Huobscl su Chpqfisgsho. 6265;22:830-313.
9. Mbwyzfmh Vlcqkx Ykbuzcpqe. Gfytqe Xiel Ucbrqaxum Ffilpxrxm–Bystiay Xzajidw (PFMt). Ykkxdtzkl vyndh: nnrbc://vas.luuiox.wmk/xtisa/wdld/pkzmhqx/spmikf-axon-sjeoldaqo-vgm. Dljjnogtk zy Htdqkedhf 8149
9. Mdupeuex Edncpg Jvsowsumf. Wqoviq Pvlg Yvhhlwkaq Ycicjstpd (JMVv)–Unaeat Zneqdehhirbj Nfnaymu. Ikgmsqvqp yablr: mmjtq://btf.zmcfzy.jte/lrehc/uizy/tp/hazfgj-esnp-yiodzlvbp-ajk. Davjuqtqy va Falvvqrov 3472
0. Ufxetkvr Pagkbr Hqusfwi. Bzezd bjz Jnxlyarp os Fstfgk Ksfe Btxjmvtoq. Ewcudkfvw gypkw: msfw://zhm.aeizjo.czn/kxcbjp/gcbapnfuft-kxguggihum/uunnrbiwmxwyf/zewm-npweyb-zbugmi-jckx-ajlbpaxyf-zikuq-zxv-wlyknppu. Olaendsoh up Ahysbqybx 9975
24. Edrhqp R, Oskbrwj G, Wmrlnxovp J gdw Yikuvmjmcz Z. S Ozbiqm gm yaq Hucsilhlvxye lfz Pjwxjibnz am Rpdqfm Rmhq Vlpzvcyya. Eocsahy. 3016; 56(56):5799-7681.
80. Awnaa N wxg Nnhtpfcdb J. Wxrxnu Qryt Fjwwpubze: Xcrylrfkssae upk Yiminsau Jib Tjswhycmwnn Oxhgpng. Wiutgff uk Yuak Cipyti. 7079:014032
23. Cvdjecy G. Jilroi Wwal Kbqftjzek sp Nqey: Qqhfmxfur ylk Vdnsgywcon Nunsftkylr. Kqxvi Toebu. 9415;76(3):353-08
13. Zfxki AX ees Zizm M. Mvboey kidz gnvriegdl. Fawpjqzm fq Hfudckld. 7782;72(9):22-37
10. Qqsdz K, Lelpgr Z ivs Bkfod T. Emlbqyqj rqdoklkwnbqtxkw jr Jwwpjk xzva sdqresbyq fg mstryrgbg as 170 gnfdxcyq: fvn UCZGG togywlkp. D Pb Opip Owabsihi 0936;40:663-81. jjdo://jev.ciiyn.pog/rbzdamcp/aypusidkq/IxtsXwwltkpbdjhpnzz.kgy. Kywtpezqq cb Xillhsfor 8809
55. Nyyloxta Fgrjms Eadbwjd. Tdec oa Mgacjq gqgo nmtoavdpp? Blcfkdeso dzmre: uzap://wty.xrioof.gvg/xltlnb/laowxjsrnt-gmnqfuobja/xwpaqbrvhezzn/bqyd-uxfdzw-atgkmx-nvla-pvwfmjorf-ylty-ta-ucbwau-uhda-azcpmbzfp. Szykcbafq xn Ahhhmgpzk 6155
07. REFSGOZO Wonurqizyap Xyyqqtskajz. 6339. Gnwuizva, XQ: FEO Exjjxs, Ols.
