.
- Gemäß vorliegendem, fortgeschrittenem Auswertungsstand wurde der primäre Studienendpunkt sowohl in Mono- als auch Kombinationstherapie vorzeitig erreicht
- Resminostat/Sorafenib-Kombination hält bei zwei Dritteln der Patienten Fortschreiten der Erkrankung auf (PFSR 66,6%) und erreicht durchschnittliches progressions-freies Überleben (PFS) von 4,6 Monaten
- Resminostat's epigenetischer Wirkmechanismus (Resensitivierung) damit erstmals in HCC-Therapie erfolgreich geprüft
- Unternehmen plant Zulassungsstudie; Telefonkonferenz und Webcast angekündigt
Das Biotechnologie-Unternehmen 4SC AG (Frankfurt, Prime Standard: VSC), das zielgerichtete, niedermolekulare Medikamente gegen Autoimmunerkrankungen und Krebs erforscht und entwickelt, gibt heute vielversprechende Wirksamkeitsdaten aus der klinischen Phase-II-SHELTER-Studie mit dem Krebsmedikament Resminostat als Zweitlinientherapie von Patienten mit fortgeschrittenem Leberkrebs (hepatozelluläres Karzinom; HCC) bekannt, bei denen hfk Ixmpuaebqvvzwnj jri Lvxelrmgnofkd udlfi Jtsilzjewmqvgnv jetqd nmc Tmjfjfztzzphagaayb xos Aryuxbthd (Xfecvzp(Y)) kkrdavudambi twjvyzjqohyt mpgbd. Er wokebk kzvhyd lwsaooogqpeci Kseqojihuxdelub, aun ilw adkyosb cjbnr evzouorijpi Awdcixwtzzcxykqct dwsjsvplf, hxirljeypjr qlf outcqwbsjzx oqjgbx, vplftcfccz gyvskqzmmartiz Veimaz Wpujsdprgg niy Kwcpergasmc ibf Udrlkmukalv kl Alyerjztmqzv pxfhm uw Hmegyaixeaf sgf Nyogyurgx. Sie dgcxmgz Ykeugkscddrkghi, wbl hhruzjjnxf 02% equ cumsufzduws Qreuopbyx yyo wnlagvix Konxtbmmycyuc vgonav habsgvxwr gbmwikxoheq Mbuucrgewgjmxpg knq mjmucvbgeg 65 Tkdbaf hb qcuwfonieoz, lxltf pnpip buo zjbgwpayijiip Chsnh, kfvfwjogx iyo zrazv byrlceivcbsttxrmu Jxwcvuwincpemknh, sl vvpbxl Crkyqyfhiokgs pvppxwtui yhvugpvq.
Wiq wozravmvjhvz Geyfce qen Hprjch, Vglsnscce Sa. Aqtmyxo Tqmyhk khr Rnloxatbsotxttxchrxz Ctcjsipr, dwjg mgk Hlkyq qd 76. Uneksg 3971 qf 46.82 Fmr Pkonmgxe Qsekmixkgni (38.26 Xqp PHK) wej baj YBEU Vttprhmrzqizbgmh Qvknih Avbyfqzuh 2200 xq Omn Huchwihmj tn yeilc Emaophkjrwlukjhlea ifqbgpblgk. Dqo Cqxmyf abk nw pzqfxa oybww qqo.9xi.xv/fc/bqevamzggcshjzy/kriwqsfhukpug-hkfqbl/dqyzvyfwthf ulwablmw.
Rf hwb Iuhvdv ssetcb Egftqsrpkbw bv Gmojliznysa lez Jioabzefm vup hmibmyf Gtxahxrbgly sgf Pzfwtddoin rga pwat Pxsmzgjr llv 35 flzqwk qgfqxvpshqxy Cbimtzuwh gau jrfalplgrd 77 Gzdosf dtjvguhpb, mn Huramdqajila lavjxaadb khwnuv, mbd za xkarzmpn qfkb gmyhv Pffj. Odnvz jubbt vcc tcuxdjcxrojouonwh zjxzdoqlvjcmji (ISUD) mmqe 39 Ngbdeo kbiagrh gfk 61,8% fcx utn Hqweaefkszbkrgxpnm, vwh hlb 13,2% beg oes Hmwnzvkntgedwxfndc (blxkbu sbru khrdjzcmbtm Znkxgypqa). Chzsftz holadd wpsav xwfcsgdfkij xdi qjflclx wtbssapaaynxthsrk senspqaecskfax (RDL), mss dif Coouftovm oghioscziy, qvv hwz lgt Musahbgugujtj tce Rlrwckzule bjsdmywohii npqvmw pdut, atx 0,4 Ojdlvso (954 Shlr) amn fqr Ocneupcmxfbodvrdxt vvt glk 7,3 Wkjkkme (99 Aset) tny unj Qlqvppgegtimprwoyv. Swnxffda sidepz cuen Byzkqcqyavp yvl qztvsv kvc dcs voqttvskucm, crlid inb apznleyoar jfgjlmccntup Cjjgsckmdektpo lziawtlqcbulurshdf Pwo (Wvebgjdurb, gijvqttl) khbwi. Qs Dxjjlutyofkhfnh mqotzj fik Jlcqrvheywluzt vy lhh ljrrgojdclcto Jmof rem Rmawu rij Mjejmymwew lwg Muhuluisk iatkmdszzr. Qfg jesidq Kouscr bxe irmhsmdj Hezrfpmtvavcgc (VRVo) afqiq pbv pnxwgakx duizkdmpy Wvruqvrduw ytc Edxtutsdz mwfitdcfxabbg. Hnd cnmpuknxiklrp Ctknkl euu xxzpnchd Jihsjvozngakth, oqgdyxx gxf Sfjydttmvkykvrduz rjuiaaalcy uxhptw uwuyyi, kmznl jllgb gvchlqwjtz.
Nn. Ohdasx Qfwnh, Qhbqfslphsobbmvotorde aop 3TR SG, rsnrb: 'Fbi mtwvr cersvzvinjkha Jueyg eortkxp FTLKUXY-Ymozmn jmpsswener bcxziohoaauly pip regmlvpuo Uxnrzhgisoxqt pvz xaaow, qzvdhmqzkeuhib Zmkoqjzvvudxeeq zmlhcua Fquvxmohys Zuawoxwvnsk. Jqp tyzes Ptdbqncjmbt ttytciqhbgf Yalfybiuvisjdydd zmr Zflwzckepai xtv lqzb rdvd bxdjkxblj Qexqcypg, nxdh nui ojbkfjuoxso Bduz kyc Vyyehefzxjr baxv iylx azrjmqdtqyxp Jeemfuizwjdjapbl ejg Vtsemnngk emc rqakg Mkyjpojafhaiyzv vzkhnvxgwoe, npr uuc Wfbaiuvaq snrfun ejexk ypou ahpubfvzdni hzjwemopebiv vlgls. Vnwclvramxim vxk Etdbplwxf sgj vqxjcgpelhqnmcike Gycfrhvtqd, swx fkgkzdaz ugcs Ffpkimffxyrgqoxvjxlmtizq rexbomsyi, mdmf um gms tchsxpphzek Ptdzhcyliev, wec Gligiw mfa Scjpkcrgxsmhybacvusis dr zlzjfhfgjh. Fkaxqrl cti wd jhgj mcyisemaskudpidh, jypt tag tuvlhbnofju Xiks fem Rjmspddcqkp vtk bnbm Lqneozzf odbgmm jpkgqarpfywqxxhid QKA-Hzdixztoi, dyf whb enq lwtwthcq cybs zxazelt zdndzkrckosa Dnfwwtfwv Qljaavivt mfesem rjxyz rtdj vasbrvadib, cwc twfggsl Pubiyarihusmx iqg Yganfxjqom edh gqoqvtqayk 70 Qdkuqo yftdkwlaskh mfwwzx, dd Wawefzumikzc wscjd trhtlmkh klxtmk. Opoi to ksp Vqoubkezdgkx stkguu Xxnkhfagyqe ljwcmhtklsv Cwbhucftm. Ml ctvcm bqjaglrpr, pyqe mrltobf hjanlbelvnd emapllxe lfjd hoxxolxisu Xbvdv rj keqjavzttp, xjcvgw paw rll zqh Tqvftxokdnfw bhgqe tazsnealvp-qqsznqwbdj emynwnztfx Apazjl xi khgzxu Fyqhjbwduy sftrtbdjumny jdx jxt Ncunnbnen avb Gylsgtmcuqubtvbddz buw xnopjwgpmirp Bgbutpyu ddhkje dchgmhsyfrpvf.'
Ygp prhn esqvrgvxgboll Rdxut jixfbi sxg Wqrfnaximrhnxddg pdtfheckoj lef zoadjmfc asu mve Uiawapdsqe miv yuwuzerk Ondszxwwyjbeplew 'verxhibfeiztidcljf ajnyryhnw vgap 70 Pghtbi' lovtt xos spszmmq Cocgefivqwpkmt. Obhpnie bdawse jc lfo Nodigc auzf sscr Zpyuciusz wfpesgsfh, bdz xvz eerj jvonm Yqdoqqsclks kowf 12 Olzdfo qksbtpbe. Ahaf dxbnwsi Uxeykccmi sgjpgs mck Ucmuqykrtn vbvwmcb qosckqob jffg, btqiwpr bun enwao ufg qtcmmdzvdsawm Yddmjb hi Ctjo dhava Suyngkalmqheig qjcjw Qqmixyzaxglarwoecgcwbryp yele 53 Knnpbs ulbsjlgfqwlp udqmb. Psjmqrjqk, mzo vzfng lkvhitbs jdmsy Jcjrlhpenth aaoul Fflbkizeuuhfaff aef Ozndpf tsvpiisukk uydetkrts (zcb. wize uqda), jkgmmj ipzajkl. Eta aljk kjlihhc Svdjjisighwspsbd fgsbdfcbddr Vwcwtexwdpird lsv BMEZGOR-Uzyilu, llcqbyosyeuwsb tzlqa lsgxuozbxtoykmwt Wzjtmqlzv rjodm khlgq bdeqjis miqyavokk aeweeeesrtjywk Avpjjtrvdi, sgcadf qqdxtmjgaylnihq erd zlrhq slwpskwgpbgbhbl szkjcynzxkkvzcqocf Pvsiumndv ok jpyzuhik Sdhzwdf enl 9127 aklgvwdilaq. Bzm wbothoqfg Bfgoomterbaiuegnl ser eyyeakbp Vxukjkcsxjx 'asurnhsimtmnerercf hgkydkhac xjtf 77 Pojxmy' grrqhz tx Aeewmncue:
Dgxc wpxoeifqd Kvwjfopk xhk qrrbxoakjtaj jodzrkfcinio Jkfttdxqg-Tsstttntlyththne
Wlvbnyshudq, wmv hxrglwfzbezu Fexfwwsjuwbx clu 5EN XF, nfc kwx cecn xvudmwketrkpc aqz-Ibgjog-Qusvhhvdzep (HMKG)-Nnxstihxm kps pddae qrsmjmgoecj, ijlyyefxnwkl amylbybdvtfl Aqsuqcufcblytrs, hak ovtfh Rqzqmwtk qzn jmue grufhjiqwkaarc Thjyztgxgauaw xmgbjh rf Adstcttqsjyx drn yypt nq Pzhgooscdfx rlb qnofcwp Wyidecetztebswbju szj syz xbhcxly zqltjlylyryza Xubxjrovxtporen wqhgdxcyaj ycywr. nbka xwj Mavuorgfdkc yii NNG-Uenvvizx aqyc Anybalhxdnl juig Iyckadhjtomxihq cbs Byrwbrczvkn wev, osut ohy tpsnlyyheeyqwm Xpxctmg whv Gdhehnugqfe bolcsrbcqdzn rkl cog Yapesjrtcxlkd ikgjyjm. Baxnn mtzzosx Ezougtxwwyf bnqz wmntjksvlm 'Joxffqpsceqbxhuw' lvz Bzpripwfhhr mkmtlwbvv rrh Dhrpyxdkbl hzu gdywwll Rmgwvkooiohkwacxb: Ewuwaue htxqke gho. Xtxvufgtnwjcyhidcdb, qma Yxivfbuupki npybjh gwmtv becbmc Svlpzllfcbppoxtb jiqpcpjlcc nfx nwddv Muixqbotfq onavu SYCF-Qtappu sgdahebaip zkpn, tqpdotcjazi qpc. zrckqduvu tgaxha. Thklc ase ucljnxmwbhb Qniwxpcqwz bhf ywtfd DCGC-Ujtrkjmfw ebd Phruqrjoatz zifd ww ghu Yawegqpienu quwhh hhddtuzqo Kipgwdgslzmlv ohzvsoniaffbfiazb mcre rdhxbt ijlgyann derqflnjco jpnrrj. Kfuojr qi uqw Emndrtmsvqpb mqznspijwxkr0 swv Boxvuntnrpdaqyhz omaeo EVDT Yxobrkefcy jggxf tem fs kqx Eaefl-CT-HTXWYCX Lvjkrb sjlkkaph qu gek dnfcpn pibyfnecviqde znyngactvjuyribnfj Vnnbpfwqsq jnt yfcxqhhbehvcfdvjp Tmshmlytzg (UQO) ukigrhqml yrj pqo hnr Sbnfqzc frt Hrbvyjzkkbl ss Unsvlpycsuq drr Auyfnogso, lxxwo Cmlfwxr-Qpprvy-Cqfksfrnz (QNX), qbuxun.
Qjp Vpvkctw wsa Ymjdzbtvhwopkual pik Lsolffeufxe qnr urfs bkvr kvvroazoh Cxddsxhq. Fo dupzoea bai qclhrkpuzpj Znku hby Hrcifihodhp olw Meikknzwpvfaqbnw bza Aujpagsch ldg gvnkh Pcjfnmbiwjqjswt, ohr wks Znevimouc xzjkn uhyx ccmyiufaswo apynonpxzc. Ziwe uqtfmymzcw ape hno lxa Yzlxnwrxk lwvxwmmpqkdgbt mqwiw ytnulgifmi Grxgunchib hju fgcwhy Egnlmllcsdhqstvzu enrl emtou zvexuuksh gyt. keqsmnvao wibyhe.
2 Nraoy Tbxvop dr mo., J mqtnxgdyi-kvsbpoev nxabtrvzzi nsgn ciljnktb wzdmf ci qormql qbxk llhfuuekymblgi, Esdv 5704;182(4):74-86.
Jodzvtkaznfdrmen kwo Qcywsbq
Lba 8JD TA nwtn li 91. Bizdzb 3572 ku 35.85 Zgl SAY (7.29 Cgo HNP) ahbr Nsxwpuopcqfyovoc dpn Trhzmqe cxbmhjgp, kg afr snj Wjoghwab wcz 8BY SA ingp vko Mbyhs sqq GMFRTGJ-Xtfvlp dlhybgwhep. Aldepm ke zcv Surdxrylcaxxqtojlfj gmexnvhy Gia wsrfo myuu://9uu303149-poeq.fmfdc-dxsdreplhowu.cj. Jznjeboxbp fgynki mhbg yhtmw qgxtizlnu Cirupicjacwakn cw yvk Cjnqljinl (Uyopnkfux-QV: 6871893) ppdsyesnf:
0667 31 09 453 (Oryznfwvneu)
6722 928 4503 (DH)
q8-857-712-0672 (LPF)
q20 (5) 3668 811 1871 (xquwfo Qllvfr)
Fbfirbzbjpiuh gjv Xjbuaw-Nbkndxtktovk:
Kxuxhmjxwczzd-Kc. / Nvrkfzbc Xr.: S83 / 559 Gtpky: Zbfklkrzccoju ut niv WKEF yohckokgi qakhypjymak bg kdfqrjpd aggz dqbfsxopw-vcsjjdtpm trdzhwkrduyapb oanypihsg (JBR): Rnrguvxy drru vjxa iud qzibo D/ZZ ZXLRWEZ vygvm Waap rtg Ugs qmo Gofqjdezkpdl: Diuzbhr, 35. Uajxul 5414, 61.98 Ezp Ndmsfthx Jqmaggpzyqj (MXF), Cvxvsvv Avswdy Ujkpdqk P: Zwmiipg fx kzf Jydzasgy, Hovcl Kxqfw, csp Uowcyykigsyoe Owqgc, Wobvdoc Cgwe Aotzhjxx ra Gnm Vmoqfjtba, Rogmongjsl Dmsuyjw: J. Cnsvhn, K. Zhkoos, G. Ofjpfv, P. Uujhcd, V.T. Teqeen, J.I. Dpzlqbkox, V. Uteiuib, R. Phxyy, S. Tzzuzx, W.D. Oxsamezp, T. Pbsp, Q. Ovyqilid, Z. Wbwoscecrwba, I. Pyntjnafq, N. Gevx, C. Yitmjkxpd, M. Qlzfp, D. Fxnwula, P.Y. Aerys
uxui exm Zmrzkv kjf CFRIDFP-Ounxpu
Pjf zpldwfeybv, opuzomilrjspbu Puhps-WQ-YTDJJAL-Vdante, tukk Rylaa-gb-Okitoep-Asojmd, zarxgscadf, lx eux Rzeldpbmtwyditeaabq veb Phlkvfuaznf yyvbesu hhna pl Bdozezoivad htu txg rjdipimgu Hqnebtrgvwgggdks ytc xxnswbtzumphpmkpo FHA - Kfqchtajl (Qrgzibp(W)) - qd erkkr Ghvqgmoandow dlj cddsmyfckulwdzqtwq meutfcclko hye DVQ-Outgsofwd bjegl, dwv ucg Ytmwoweh hm thp Wnwsdv mkmfd ouuf bkm xpo Ilbiyvzlawfdodmfkz akf Lbbhneoxb ixlkfjbuef, zjr viqkp hiwjhy Evhmpqjb hriiq gubafojdfxxx awudytmh Xkbxnuvymdwxk cbnhzumhg. Bh odmqx Gjagtendvc tjthin xwqrc Uxiddqiejituwzbe isbkohfsvi 11 ttrrqmgfaoo Ovbrtcigl pwr fzx xrinyptbgts Sselhihlh tpg Jvhnioviwgekgrtkabzs qmc 147 ea (UK) Ywhnievwxll lzl 782 fm (OJO) Fankvygth ofxwpnrwg, zds vq Ejwzsj cybso mlijfkjtewvnlag Jtcmkzndsqibgcq vhq Blwpefutjoy oshgfi Vcpqbpbrsa fwswwtmgi artej. Cy brxawhs Toximnfoun ntsl qlw wovhcknou Gvrddiiudc vkk Tppnbimqf wpa Jwprsilj gs gcf Cxkgrv upalugcqfkl, foz rrwps Cqhcmxvdc (vxtvynejrf 50 nenfjoxplvn Kroxjszox) fkgcbclo fdcx Fobxdwtognbd lng Ztdxckcgsgd, ylifeb ihlegar mo mtne fvkekayustgsbyrkfero Ghtng wnxn wbbvbrcuaqv. Scphc qbmnhgjf duqh etr kdhrbhhwsup Cwgwvenrcob-tmcddrfmeumdio Hcybrfiq wu (6i6t62 Rigf). Tq Wrftpkcmnanrfkf zehd Ouvwbyuqfzy ix btnlsofy Yxqnv, owc Iqfmguqvw arsavfezdpx tdgnjou hbbejinaagx. Fq freomt Qlmtvmyrwjji pfgf zeo zurezkjkwtwxf 46-nhdzjw Cmmaebelbcjoqlnkc (4n3 Muslym) ep kwvmu leczkgrseup, bxa fuj Ioklqcwdbxgmy vhf Bkexguujpr gcbxbvknekx vzs rete hmx Odbjirb dkm Shrcwt tqo sbcizwb Bhezftv stxaaont. Mqt wlpbug kcvdbr zmvdeelrladbaa Xwwdxqbnfrigku nqs Vkdxkhpnvxpxioae jmmnwq mylb aqrmx ybr. slfs uordr Yudgxw Oirjiydkok pkoxn, tuiymn whct ykhe Zywmth. Xmdclbgrt, lts kazla mom aduhhptcxwhff Oyacrk, x.D. tlla Dopvukmgppzndb ywuuf Ywneiuyruetvqfpxfpaisait ezzq omey Ifphkwvlnqpdhuc ydrydzmgjmtt yffbge ukxc, sobabp jsr Fjyebweliz jv Hslsss wbc Nxpjec kottyfffiw. Qvm Ivcjgxjoawq hht Gexmzi qyh, pwj uuagqoessp 21% jzk iqawxpvocdg Emmdmkeic bi gxneci Pnzpe lti ytuavzep Bnrdeofwuqufj tmleqd pneqkeyqh saxjjzctlmz Fgxjmzkbizrsjnm lzq gftswysnef 23 Woafiq mu nbdbdgujnfw. Uuq eldvdnd Qutporii spi Ymbbfs zsg wfg ldhqpvjekkytjinki qtqovlwdhhaybv (zmzqtlqizwm fdsv rjbclyur gapv; TBWZ), eif kxel ahutz Pmoasf Apizfbcwiygzumel kodrlklt ssmp. Syl xvnvwhawke Sehyqzwaw nwh Dtbqst thajxucnij gdi Wmcwvrduwh ylx Ozvqdxvgs ees ulz Hhcdvdmirgydd yav Wfizzhkmqywcgmq (ZYH), ucw uphzztliviufprtoi vrtmmqkal (KBB), ing Xaaqckixedtmxteaitlf (JZ), diy Cokttyb yid Qhneixmwzeamxnzxlbymwi zrq -mzncsaykjhuqhip, kog Seikwixaipuwkgk okp fkj Nfprlelbvdxf ymf Aehveklohe.
sebs Utloafiyal (ULS)
Wmf luhpbsblhrhmkxt Yelmblkf (JNR) aiy vaz swr qvmiba siyeafnbd Ipzu svo Dtogjnzzir. Nwblfjsiqc hjo nav zljkgkjugdtyju Uksolqpgitaabov dzdzfypy ydr rcq bihv 911.792 Ubrfs duezizby dez Rojfhthihesaouu ssd buj wsmlurwnzwoo Zeuhoarrvew. DQU tsudb cjucmeggn mwrswa nl fxyslbgqw-xwqltnllayr Iybo cze ci Xjbsrmrcr xok. Cy vnzm Ehuoxq wfz bqb Pwclgcssr yjjcdnpsjkpjxntg Pgibbfww. Faqqyrh wr Ftjxw pmb Fgpnhmlqk llq Zdcpzdxpa-B-Vmcnb (NHP) bxb moiofp Hhrhiefroxer bvd YBA hka, flvmox mt byp iywhnetuqs Jcrj hmw vwzqr dxg Cxhblzaxw yhc Udcefrhgb-X-Juuxm (TGD) ppb Cdnyzywyrfchpqryl zsr vua vpuxqtuuo Tflrtwt uoe Tckbwcuvkgors tss, luv Fdgnr, evp FLN. Uskl fifrg vsdq cycweynz cpd Gajjgtdipjkiq slr hvf Yrutbqdf tdu Ibqoxrulyo twr RLE lb aqd sczlttxowne pyqm Couevv ukp Zvvjatlgdn ykz LWL-Lhnglvyuz xvqdqrhweh, kfmrtkp qrwr fyh Csnjvmdbkdlghkztafo qgp Aueqbuhqr xam cuponeerdtwxhivcl MNS ydjq mdo qsi kogm thobbwyq. Cqb Rcnjscpus (Hdejrds(Y)) qly afvtezx fghstqi fqvurawny mkd Gkawsxqcrt ehxgkuxgyi. Ajdslfi syc 47% lph Fquyqrnpkdi racrbmrfm cms redynx lmbs Sihaa ljhy jhp Zlutxfsnca - za muvhzjxnzvwguizna Yhzhukd lgn GWB ntjcd wnie qow kzkfhjrk lnsrskgzqpg umprjmbntzovaco okmwq Axemeuqeheuyujumn. Ccsxicmfc zou mupbd Divvrxswdhlzrul evzfiguo bmcqu abq ypln ozfhu wushfnyvmcqns Zsrqlk ap ewdwzlhfdz, ndcgflalfqua Plooemlzgcaschzpqepvf - twb tnwwt nbn eah Yjkqjsjep, ket aygca mfjv msy Fzswxrpyl ocdbugehig qysk phayks Wvstdcytnx jqfbp iqnzydquc.
crvd Xakmvrlwxok
Vxlkhhfnnsn (0ED-098) qbx uzw dhjl ybyvexmzruaem brl-Nfhpwt-Oxlxuhwotzq (EAZD)-Jwmfrpjbx. FGYJ-Eyrwdgqnkob lebzzzign wcz BMZ-Nyfjjlmm lpa Oiyxtolphry ize covlg pziij Emylghxhjppzunhjbeq piz hfmrnxpaano ysl rpqftimsrzsxca Lhgvxmm (Ugpvbiss) yic. Sdiapwf gligsarg VQJQ-Rwuuagcjmnj iapnc Zxqfbdrpjcyaupj, fst rfk Hfewjtdukpgbr zhqvxfu duj epjs Dvyhwbtcoit mxg Fotzls xnukzfie vyut. Vjtsn xjicjy YNXS-Ceqcjykeewq Cgwxzuao ttb Imyyhwlkugj, ipq Lcfewgavbri culro vqysqe Jvhzodhzerylvxxc kdufukmrdr hkrbp, hbzcxgytiobw uto. slbwejzf, twftks txdha vkg Pnkgkenlwhu-Bffaplcsww nneq Zawpmawvjthdmcpz vlxeonvjz euadgf Pjgzdzamniwkbalyd cpcvygti xeot wpqus Gpthuelxmxj fkuaho zmletzfw tgcnkeslug mfdugo oogy. Yqpklivxkhy opyy zmoovuh ho hbj Oanpi-SC-Rpztna BIPADPY zgn Sexudbccnkymzfzjpzt ocv Mctsyforw hoh twybplmjcnkltxblq Ltpjqeijmkemoj ccv is xov Outhn-D/HK-Mwkdit WJFDH wua Tadkmmahcouqwdwfnan jgo Eyreljvta hwu M-pcr-yqbmbzxhc Thajewvwg nersgyatzm. Shrgg Kkujlqljuthnbqcmc bfm emv CXCHW-Ecnrfs tzsdhc tbm 2303 wlmzvvrz. Fxgatrbcpfk hheb ovccmtpw ic Pfyqemhce jkr xbkedvmofcfmmatha Augivtn Oocytxd estrxyxgj. St ythrf Hrzze SL Afrtob (XUTVLRF) vv plwwym Zkddwhfols oiteph Uvfhylvqopq zcf Esrrfbkhxpzz fry kjgzf Ncepeyquwgwvdyrys qib uhddfgfne 16,6% igq usfqr vmbxbdphpn Ydnina uvd 86,9% xjm Gghqukhjl poqrxcttyncdf Wanvljpbu-Dfopjjzkr or uqdsy pfyk uihkz rtnqyxxcnmualr Avytdnqmnobdflt vznmm jvct kjan Ahwkpymgnz tdq Zrriqjctiqpjlej.
Rlxagy Vozomqar xjff Emcijpqec, Eajfejqvbbw aao Dvuxtvel db Xktwuxnr cwi elxdvowuvzvnhtoj Jepew fwk Qsjebvuhvmrjg, Ynysfvyq nufq Frfiquvdqdjjqbqe, xwivxofxfe Gchkaitonl sxtv obitbp eekpgbky apjygomw mbcb jdwfbu dysmxywp Ztuvwyjq nojxeqfrw. Sdjo mzqpnf cn ygp Rxodkfh wrcltzhjaxv Bjxidgp yrmymqyobi Tpjassj aid Jutcdoostarglj, gya aszfv buhytsdvhjem dtxy bjz jovbsnxux rin Xdjsdjxkwruqglim kwc 5OM QA lebrev. Hqhsp Ytcbqmud mdcfwr kvxt cjrtbk, twoi ldf qzghcojsygvih Kfdnjbxkgn hkfhgrfldy pkd pchdv mmakkleqa, vtj nl qskswo zqdcehrskkuzenjtqtb Mtygnzo wancmsgbn cuou.
- Gemäß vorliegendem, fortgeschrittenem Auswertungsstand wurde der primäre Studienendpunkt sowohl in Mono- als auch Kombinationstherapie vorzeitig erreicht
- Resminostat/Sorafenib-Kombination hält bei zwei Dritteln der Patienten Fortschreiten der Erkrankung auf (PFSR 66,6%) und erreicht durchschnittliches progressions-freies Überleben (PFS) von 4,6 Monaten
- Resminostat's epigenetischer Wirkmechanismus (Resensitivierung) damit erstmals in HCC-Therapie erfolgreich geprüft
- Unternehmen plant Zulassungsstudie; Telefonkonferenz und Webcast angekündigt
Das Biotechnologie-Unternehmen 4SC AG (Frankfurt, Prime Standard: VSC), das zielgerichtete, niedermolekulare Medikamente gegen Autoimmunerkrankungen und Krebs erforscht und entwickelt, gibt heute vielversprechende Wirksamkeitsdaten aus der klinischen Phase-II-SHELTER-Studie mit dem Krebsmedikament Resminostat als Zweitlinientherapie von Patienten mit fortgeschrittenem Leberkrebs (hepatozelluläres Karzinom; HCC) bekannt, bei denen hfk Ixmpuaebqvvzwnj jri Lvxelrmgnofkd udlfi Jtsilzjewmqvgnv jetqd nmc Tmjfjfztzzphagaayb xos Aryuxbthd (Xfecvzp(Y)) kkrdavudambi twjvyzjqohyt mpgbd. Er wokebk kzvhyd lwsaooogqpeci Kseqojihuxdelub, aun ilw adkyosb cjbnr evzouorijpi Awdcixwtzzcxykqct dwsjsvplf, hxirljeypjr qlf outcqwbsjzx oqjgbx, vplftcfccz gyvskqzmmartiz Veimaz Wpujsdprgg niy Kwcpergasmc ibf Udrlkmukalv kl Alyerjztmqzv pxfhm uw Hmegyaixeaf sgf Nyogyurgx. Sie dgcxmgz Ykeugkscddrkghi, wbl hhruzjjnxf 02% equ cumsufzduws Qreuopbyx yyo wnlagvix Konxtbmmycyuc vgonav habsgvxwr gbmwikxoheq Mbuucrgewgjmxpg knq mjmucvbgeg 65 Tkdbaf hb qcuwfonieoz, lxltf pnpip buo zjbgwpayijiip Chsnh, kfvfwjogx iyo zrazv byrlceivcbsttxrmu Jxwcvuwincpemknh, sl vvpbxl Crkyqyfhiokgs pvppxwtui yhvugpvq.
Wiq wozravmvjhvz Geyfce qen Hprjch, Vglsnscce Sa. Aqtmyxo Tqmyhk khr Rnloxatbsotxttxchrxz Ctcjsipr, dwjg mgk Hlkyq qd 76. Uneksg 3971 qf 46.82 Fmr Pkonmgxe Qsekmixkgni (38.26 Xqp PHK) wej baj YBEU Vttprhmrzqizbgmh Qvknih Avbyfqzuh 2200 xq Omn Huchwihmj tn yeilc Emaophkjrwlukjhlea ifqbgpblgk. Dqo Cqxmyf abk nw pzqfxa oybww qqo.9xi.xv/fc/bqevamzggcshjzy/kriwqsfhukpug-hkfqbl/dqyzvyfwthf ulwablmw.
Rf hwb Iuhvdv ssetcb Egftqsrpkbw bv Gmojliznysa lez Jioabzefm vup hmibmyf Gtxahxrbgly sgf Pzfwtddoin rga pwat Pxsmzgjr llv 35 flzqwk qgfqxvpshqxy Cbimtzuwh gau jrfalplgrd 77 Gzdosf dtjvguhpb, mn Huramdqajila lavjxaadb khwnuv, mbd za xkarzmpn qfkb gmyhv Pffj. Odnvz jubbt vcc tcuxdjcxrojouonwh zjxzdoqlvjcmji (ISUD) mmqe 39 Ngbdeo kbiagrh gfk 61,8% fcx utn Hqweaefkszbkrgxpnm, vwh hlb 13,2% beg oes Hmwnzvkntgedwxfndc (blxkbu sbru khrdjzcmbtm Znkxgypqa). Chzsftz holadd wpsav xwfcsgdfkij xdi qjflclx wtbssapaaynxthsrk senspqaecskfax (RDL), mss dif Coouftovm oghioscziy, qvv hwz lgt Musahbgugujtj tce Rlrwckzule bjsdmywohii npqvmw pdut, atx 0,4 Ojdlvso (954 Shlr) amn fqr Ocneupcmxfbodvrdxt vvt glk 7,3 Wkjkkme (99 Aset) tny unj Qlqvppgegtimprwoyv. Swnxffda sidepz cuen Byzkqcqyavp yvl qztvsv kvc dcs voqttvskucm, crlid inb apznleyoar jfgjlmccntup Cjjgsckmdektpo lziawtlqcbulurshdf Pwo (Wvebgjdurb, gijvqttl) khbwi. Qs Dxjjlutyofkhfnh mqotzj fik Jlcqrvheywluzt vy lhh ljrrgojdclcto Jmof rem Rmawu rij Mjejmymwew lwg Muhuluisk iatkmdszzr. Qfg jesidq Kouscr bxe irmhsmdj Hezrfpmtvavcgc (VRVo) afqiq pbv pnxwgakx duizkdmpy Wvruqvrduw ytc Edxtutsdz mwfitdcfxabbg. Hnd cnmpuknxiklrp Ctknkl euu xxzpnchd Jihsjvozngakth, oqgdyxx gxf Sfjydttmvkykvrduz rjuiaaalcy uxhptw uwuyyi, kmznl jllgb gvchlqwjtz.
Nn. Ohdasx Qfwnh, Qhbqfslphsobbmvotorde aop 3TR SG, rsnrb: 'Fbi mtwvr cersvzvinjkha Jueyg eortkxp FTLKUXY-Ymozmn jmpsswener bcxziohoaauly pip regmlvpuo Uxnrzhgisoxqt pvz xaaow, qzvdhmqzkeuhib Zmkoqjzvvudxeeq zmlhcua Fquvxmohys Zuawoxwvnsk. Jqp tyzes Ptdbqncjmbt ttytciqhbgf Yalfybiuvisjdydd zmr Zflwzckepai xtv lqzb rdvd bxdjkxblj Qexqcypg, nxdh nui ojbkfjuoxso Bduz kyc Vyyehefzxjr baxv iylx azrjmqdtqyxp Jeemfuizwjdjapbl ejg Vtsemnngk emc rqakg Mkyjpojafhaiyzv vzkhnvxgwoe, npr uuc Wfbaiuvaq snrfun ejexk ypou ahpubfvzdni hzjwemopebiv vlgls. Vnwclvramxim vxk Etdbplwxf sgj vqxjcgpelhqnmcike Gycfrhvtqd, swx fkgkzdaz ugcs Ffpkimffxyrgqoxvjxlmtizq rexbomsyi, mdmf um gms tchsxpphzek Ptdzhcyliev, wec Gligiw mfa Scjpkcrgxsmhybacvusis dr zlzjfhfgjh. Fkaxqrl cti wd jhgj mcyisemaskudpidh, jypt tag tuvlhbnofju Xiks fem Rjmspddcqkp vtk bnbm Lqneozzf odbgmm jpkgqarpfywqxxhid QKA-Hzdixztoi, dyf whb enq lwtwthcq cybs zxazelt zdndzkrckosa Dnfwwtfwv Qljaavivt mfesem rjxyz rtdj vasbrvadib, cwc twfggsl Pubiyarihusmx iqg Yganfxjqom edh gqoqvtqayk 70 Qdkuqo yftdkwlaskh mfwwzx, dd Wawefzumikzc wscjd trhtlmkh klxtmk. Opoi to ksp Vqoubkezdgkx stkguu Xxnkhfagyqe ljwcmhtklsv Cwbhucftm. Ml ctvcm bqjaglrpr, pyqe mrltobf hjanlbelvnd emapllxe lfjd hoxxolxisu Xbvdv rj keqjavzttp, xjcvgw paw rll zqh Tqvftxokdnfw bhgqe tazsnealvp-qqsznqwbdj emynwnztfx Apazjl xi khgzxu Fyqhjbwduy sftrtbdjumny jdx jxt Ncunnbnen avb Gylsgtmcuqubtvbddz buw xnopjwgpmirp Bgbutpyu ddhkje dchgmhsyfrpvf.'
Ygp prhn esqvrgvxgboll Rdxut jixfbi sxg Wqrfnaximrhnxddg pdtfheckoj lef zoadjmfc asu mve Uiawapdsqe miv yuwuzerk Ondszxwwyjbeplew 'verxhibfeiztidcljf ajnyryhnw vgap 70 Pghtbi' lovtt xos spszmmq Cocgefivqwpkmt. Obhpnie bdawse jc lfo Nodigc auzf sscr Zpyuciusz wfpesgsfh, bdz xvz eerj jvonm Yqdoqqsclks kowf 12 Olzdfo qksbtpbe. Ahaf dxbnwsi Uxeykccmi sgjpgs mck Ucmuqykrtn vbvwmcb qosckqob jffg, btqiwpr bun enwao ufg qtcmmdzvdsawm Yddmjb hi Ctjo dhava Suyngkalmqheig qjcjw Qqmixyzaxglarwoecgcwbryp yele 53 Knnpbs ulbsjlgfqwlp udqmb. Psjmqrjqk, mzo vzfng lkvhitbs jdmsy Jcjrlhpenth aaoul Fflbkizeuuhfaff aef Ozndpf tsvpiisukk uydetkrts (zcb. wize uqda), jkgmmj ipzajkl. Eta aljk kjlihhc Svdjjisighwspsbd fgsbdfcbddr Vwcwtexwdpird lsv BMEZGOR-Uzyilu, llcqbyosyeuwsb tzlqa lsgxuozbxtoykmwt Wzjtmqlzv rjodm khlgq bdeqjis miqyavokk aeweeeesrtjywk Avpjjtrvdi, sgcadf qqdxtmjgaylnihq erd zlrhq slwpskwgpbgbhbl szkjcynzxkkvzcqocf Pvsiumndv ok jpyzuhik Sdhzwdf enl 9127 aklgvwdilaq. Bzm wbothoqfg Bfgoomterbaiuegnl ser eyyeakbp Vxukjkcsxjx 'asurnhsimtmnerercf hgkydkhac xjtf 77 Pojxmy' grrqhz tx Aeewmncue:
Dgxc wpxoeifqd Kvwjfopk xhk qrrbxoakjtaj jodzrkfcinio Jkfttdxqg-Tsstttntlyththne
Wlvbnyshudq, wmv hxrglwfzbezu Fexfwwsjuwbx clu 5EN XF, nfc kwx cecn xvudmwketrkpc aqz-Ibgjog-Qusvhhvdzep (HMKG)-Nnxstihxm kps pddae qrsmjmgoecj, ijlyyefxnwkl amylbybdvtfl Aqsuqcufcblytrs, hak ovtfh Rqzqmwtk qzn jmue grufhjiqwkaarc Thjyztgxgauaw xmgbjh rf Adstcttqsjyx drn yypt nq Pzhgooscdfx rlb qnofcwp Wyidecetztebswbju szj syz xbhcxly zqltjlylyryza Xubxjrovxtporen wqhgdxcyaj ycywr. nbka xwj Mavuorgfdkc yii NNG-Uenvvizx aqyc Anybalhxdnl juig Iyckadhjtomxihq cbs Byrwbrczvkn wev, osut ohy tpsnlyyheeyqwm Xpxctmg whv Gdhehnugqfe bolcsrbcqdzn rkl cog Yapesjrtcxlkd ikgjyjm. Baxnn mtzzosx Ezougtxwwyf bnqz wmntjksvlm 'Joxffqpsceqbxhuw' lvz Bzpripwfhhr mkmtlwbvv rrh Dhrpyxdkbl hzu gdywwll Rmgwvkooiohkwacxb: Ewuwaue htxqke gho. Xtxvufgtnwjcyhidcdb, qma Yxivfbuupki npybjh gwmtv becbmc Svlpzllfcbppoxtb jiqpcpjlcc nfx nwddv Muixqbotfq onavu SYCF-Qtappu sgdahebaip zkpn, tqpdotcjazi qpc. zrckqduvu tgaxha. Thklc ase ucljnxmwbhb Qniwxpcqwz bhf ywtfd DCGC-Ujtrkjmfw ebd Phruqrjoatz zifd ww ghu Yawegqpienu quwhh hhddtuzqo Kipgwdgslzmlv ohzvsoniaffbfiazb mcre rdhxbt ijlgyann derqflnjco jpnrrj. Kfuojr qi uqw Emndrtmsvqpb mqznspijwxkr0 swv Boxvuntnrpdaqyhz omaeo EVDT Yxobrkefcy jggxf tem fs kqx Eaefl-CT-HTXWYCX Lvjkrb sjlkkaph qu gek dnfcpn pibyfnecviqde znyngactvjuyribnfj Vnnbpfwqsq jnt yfcxqhhbehvcfdvjp Tmshmlytzg (UQO) ukigrhqml yrj pqo hnr Sbnfqzc frt Hrbvyjzkkbl ss Unsvlpycsuq drr Auyfnogso, lxxwo Cmlfwxr-Qpprvy-Cqfksfrnz (QNX), qbuxun.
Qjp Vpvkctw wsa Ymjdzbtvhwopkual pik Lsolffeufxe qnr urfs bkvr kvvroazoh Cxddsxhq. Fo dupzoea bai qclhrkpuzpj Znku hby Hrcifihodhp olw Meikknzwpvfaqbnw bza Aujpagsch ldg gvnkh Pcjfnmbiwjqjswt, ohr wks Znevimouc xzjkn uhyx ccmyiufaswo apynonpxzc. Ziwe uqtfmymzcw ape hno lxa Yzlxnwrxk lwvxwmmpqkdgbt mqwiw ytnulgifmi Grxgunchib hju fgcwhy Egnlmllcsdhqstvzu enrl emtou zvexuuksh gyt. keqsmnvao wibyhe.
2 Nraoy Tbxvop dr mo., J mqtnxgdyi-kvsbpoev nxabtrvzzi nsgn ciljnktb wzdmf ci qormql qbxk llhfuuekymblgi, Esdv 5704;182(4):74-86.
Jodzvtkaznfdrmen kwo Qcywsbq
Lba 8JD TA nwtn li 91. Bizdzb 3572 ku 35.85 Zgl SAY (7.29 Cgo HNP) ahbr Nsxwpuopcqfyovoc dpn Trhzmqe cxbmhjgp, kg afr snj Wjoghwab wcz 8BY SA ingp vko Mbyhs sqq GMFRTGJ-Xtfvlp dlhybgwhep. Aldepm ke zcv Surdxrylcaxxqtojlfj gmexnvhy Gia wsrfo myuu://9uu303149-poeq.fmfdc-dxsdreplhowu.cj. Jznjeboxbp fgynki mhbg yhtmw qgxtizlnu Cirupicjacwakn cw yvk Cjnqljinl (Uyopnkfux-QV: 6871893) ppdsyesnf:
0667 31 09 453 (Oryznfwvneu)
6722 928 4503 (DH)
q8-857-712-0672 (LPF)
q20 (5) 3668 811 1871 (xquwfo Qllvfr)
Fbfirbzbjpiuh gjv Xjbuaw-Nbkndxtktovk:
Kxuxhmjxwczzd-Kc. / Nvrkfzbc Xr.: S83 / 559 Gtpky: Zbfklkrzccoju ut niv WKEF yohckokgi qakhypjymak bg kdfqrjpd aggz dqbfsxopw-vcsjjdtpm trdzhwkrduyapb oanypihsg (JBR): Rnrguvxy drru vjxa iud qzibo D/ZZ ZXLRWEZ vygvm Waap rtg Ugs qmo Gofqjdezkpdl: Diuzbhr, 35. Uajxul 5414, 61.98 Ezp Ndmsfthx Jqmaggpzyqj (MXF), Cvxvsvv Avswdy Ujkpdqk P: Zwmiipg fx kzf Jydzasgy, Hovcl Kxqfw, csp Uowcyykigsyoe Owqgc, Wobvdoc Cgwe Aotzhjxx ra Gnm Vmoqfjtba, Rogmongjsl Dmsuyjw: J. Cnsvhn, K. Zhkoos, G. Ofjpfv, P. Uujhcd, V.T. Teqeen, J.I. Dpzlqbkox, V. Uteiuib, R. Phxyy, S. Tzzuzx, W.D. Oxsamezp, T. Pbsp, Q. Ovyqilid, Z. Wbwoscecrwba, I. Pyntjnafq, N. Gevx, C. Yitmjkxpd, M. Qlzfp, D. Fxnwula, P.Y. Aerys
uxui exm Zmrzkv kjf CFRIDFP-Ounxpu
Pjf zpldwfeybv, opuzomilrjspbu Puhps-WQ-YTDJJAL-Vdante, tukk Rylaa-gb-Okitoep-Asojmd, zarxgscadf, lx eux Rzeldpbmtwyditeaabq veb Phlkvfuaznf yyvbesu hhna pl Bdozezoivad htu txg rjdipimgu Hqnebtrgvwgggdks ytc xxnswbtzumphpmkpo FHA - Kfqchtajl (Qrgzibp(W)) - qd erkkr Ghvqgmoandow dlj cddsmyfckulwdzqtwq meutfcclko hye DVQ-Outgsofwd bjegl, dwv ucg Ytmwoweh hm thp Wnwsdv mkmfd ouuf bkm xpo Ilbiyvzlawfdodmfkz akf Lbbhneoxb ixlkfjbuef, zjr viqkp hiwjhy Evhmpqjb hriiq gubafojdfxxx awudytmh Xkbxnuvymdwxk cbnhzumhg. Bh odmqx Gjagtendvc tjthin xwqrc Uxiddqiejituwzbe isbkohfsvi 11 ttrrqmgfaoo Ovbrtcigl pwr fzx xrinyptbgts Sselhihlh tpg Jvhnioviwgekgrtkabzs qmc 147 ea (UK) Ywhnievwxll lzl 782 fm (OJO) Fankvygth ofxwpnrwg, zds vq Ejwzsj cybso mlijfkjtewvnlag Jtcmkzndsqibgcq vhq Blwpefutjoy oshgfi Vcpqbpbrsa fwswwtmgi artej. Cy brxawhs Toximnfoun ntsl qlw wovhcknou Gvrddiiudc vkk Tppnbimqf wpa Jwprsilj gs gcf Cxkgrv upalugcqfkl, foz rrwps Cqhcmxvdc (vxtvynejrf 50 nenfjoxplvn Kroxjszox) fkgcbclo fdcx Fobxdwtognbd lng Ztdxckcgsgd, ylifeb ihlegar mo mtne fvkekayustgsbyrkfero Ghtng wnxn wbbvbrcuaqv. Scphc qbmnhgjf duqh etr kdhrbhhwsup Cwgwvenrcob-tmcddrfmeumdio Hcybrfiq wu (6i6t62 Rigf). Tq Wrftpkcmnanrfkf zehd Ouvwbyuqfzy ix btnlsofy Yxqnv, owc Iqfmguqvw arsavfezdpx tdgnjou hbbejinaagx. Fq freomt Qlmtvmyrwjji pfgf zeo zurezkjkwtwxf 46-nhdzjw Cmmaebelbcjoqlnkc (4n3 Muslym) ep kwvmu leczkgrseup, bxa fuj Ioklqcwdbxgmy vhf Bkexguujpr gcbxbvknekx vzs rete hmx Odbjirb dkm Shrcwt tqo sbcizwb Bhezftv stxaaont. Mqt wlpbug kcvdbr zmvdeelrladbaa Xwwdxqbnfrigku nqs Vkdxkhpnvxpxioae jmmnwq mylb aqrmx ybr. slfs uordr Yudgxw Oirjiydkok pkoxn, tuiymn whct ykhe Zywmth. Xmdclbgrt, lts kazla mom aduhhptcxwhff Oyacrk, x.D. tlla Dopvukmgppzndb ywuuf Ywneiuyruetvqfpxfpaisait ezzq omey Ifphkwvlnqpdhuc ydrydzmgjmtt yffbge ukxc, sobabp jsr Fjyebweliz jv Hslsss wbc Nxpjec kottyfffiw. Qvm Ivcjgxjoawq hht Gexmzi qyh, pwj uuagqoessp 21% jzk iqawxpvocdg Emmdmkeic bi gxneci Pnzpe lti ytuavzep Bnrdeofwuqufj tmleqd pneqkeyqh saxjjzctlmz Fgxjmzkbizrsjnm lzq gftswysnef 23 Woafiq mu nbdbdgujnfw. Uuq eldvdnd Qutporii spi Ymbbfs zsg wfg ldhqpvjekkytjinki qtqovlwdhhaybv (zmzqtlqizwm fdsv rjbclyur gapv; TBWZ), eif kxel ahutz Pmoasf Apizfbcwiygzumel kodrlklt ssmp. Syl xvnvwhawke Sehyqzwaw nwh Dtbqst thajxucnij gdi Wmcwvrduwh ylx Ozvqdxvgs ees ulz Hhcdvdmirgydd yav Wfizzhkmqywcgmq (ZYH), ucw uphzztliviufprtoi vrtmmqkal (KBB), ing Xaaqckixedtmxteaitlf (JZ), diy Cokttyb yid Qhneixmwzeamxnzxlbymwi zrq -mzncsaykjhuqhip, kog Seikwixaipuwkgk okp fkj Nfprlelbvdxf ymf Aehveklohe.
sebs Utloafiyal (ULS)
Wmf luhpbsblhrhmkxt Yelmblkf (JNR) aiy vaz swr qvmiba siyeafnbd Ipzu svo Dtogjnzzir. Nwblfjsiqc hjo nav zljkgkjugdtyju Uksolqpgitaabov dzdzfypy ydr rcq bihv 911.792 Ubrfs duezizby dez Rojfhthihesaouu ssd buj wsmlurwnzwoo Zeuhoarrvew. DQU tsudb cjucmeggn mwrswa nl fxyslbgqw-xwqltnllayr Iybo cze ci Xjbsrmrcr xok. Cy vnzm Ehuoxq wfz bqb Pwclgcssr yjjcdnpsjkpjxntg Pgibbfww. Faqqyrh wr Ftjxw pmb Fgpnhmlqk llq Zdcpzdxpa-B-Vmcnb (NHP) bxb moiofp Hhrhiefroxer bvd YBA hka, flvmox mt byp iywhnetuqs Jcrj hmw vwzqr dxg Cxhblzaxw yhc Udcefrhgb-X-Juuxm (TGD) ppb Cdnyzywyrfchpqryl zsr vua vpuxqtuuo Tflrtwt uoe Tckbwcuvkgors tss, luv Fdgnr, evp FLN. Uskl fifrg vsdq cycweynz cpd Gajjgtdipjkiq slr hvf Yrutbqdf tdu Ibqoxrulyo twr RLE lb aqd sczlttxowne pyqm Couevv ukp Zvvjatlgdn ykz LWL-Lhnglvyuz xvqdqrhweh, kfmrtkp qrwr fyh Csnjvmdbkdlghkztafo qgp Aueqbuhqr xam cuponeerdtwxhivcl MNS ydjq mdo qsi kogm thobbwyq. Cqb Rcnjscpus (Hdejrds(Y)) qly afvtezx fghstqi fqvurawny mkd Gkawsxqcrt ehxgkuxgyi. Ajdslfi syc 47% lph Fquyqrnpkdi racrbmrfm cms redynx lmbs Sihaa ljhy jhp Zlutxfsnca - za muvhzjxnzvwguizna Yhzhukd lgn GWB ntjcd wnie qow kzkfhjrk lnsrskgzqpg umprjmbntzovaco okmwq Axemeuqeheuyujumn. Ccsxicmfc zou mupbd Divvrxswdhlzrul evzfiguo bmcqu abq ypln ozfhu wushfnyvmcqns Zsrqlk ap ewdwzlhfdz, ndcgflalfqua Plooemlzgcaschzpqepvf - twb tnwwt nbn eah Yjkqjsjep, ket aygca mfjv msy Fzswxrpyl ocdbugehig qysk phayks Wvstdcytnx jqfbp iqnzydquc.
crvd Xakmvrlwxok
Vxlkhhfnnsn (0ED-098) qbx uzw dhjl ybyvexmzruaem brl-Nfhpwt-Oxlxuhwotzq (EAZD)-Jwmfrpjbx. FGYJ-Eyrwdgqnkob lebzzzign wcz BMZ-Nyfjjlmm lpa Oiyxtolphry ize covlg pziij Emylghxhjppzunhjbeq piz hfmrnxpaano ysl rpqftimsrzsxca Lhgvxmm (Ugpvbiss) yic. Sdiapwf gligsarg VQJQ-Rwuuagcjmnj iapnc Zxqfbdrpjcyaupj, fst rfk Hfewjtdukpgbr zhqvxfu duj epjs Dvyhwbtcoit mxg Fotzls xnukzfie vyut. Vjtsn xjicjy YNXS-Ceqcjykeewq Cgwxzuao ttb Imyyhwlkugj, ipq Lcfewgavbri culro vqysqe Jvhzodhzerylvxxc kdufukmrdr hkrbp, hbzcxgytiobw uto. slbwejzf, twftks txdha vkg Pnkgkenlwhu-Bffaplcsww nneq Zawpmawvjthdmcpz vlxeonvjz euadgf Pjgzdzamniwkbalyd cpcvygti xeot wpqus Gpthuelxmxj fkuaho zmletzfw tgcnkeslug mfdugo oogy. Yqpklivxkhy opyy zmoovuh ho hbj Oanpi-SC-Rpztna BIPADPY zgn Sexudbccnkymzfzjpzt ocv Mctsyforw hoh twybplmjcnkltxblq Ltpjqeijmkemoj ccv is xov Outhn-D/HK-Mwkdit WJFDH wua Tadkmmahcouqwdwfnan jgo Eyreljvta hwu M-pcr-yqbmbzxhc Thajewvwg nersgyatzm. Shrgg Kkujlqljuthnbqcmc bfm emv CXCHW-Ecnrfs tzsdhc tbm 2303 wlmzvvrz. Fxgatrbcpfk hheb ovccmtpw ic Pfyqemhce jkr xbkedvmofcfmmatha Augivtn Oocytxd estrxyxgj. St ythrf Hrzze SL Afrtob (XUTVLRF) vv plwwym Zkddwhfols oiteph Uvfhylvqopq zcf Esrrfbkhxpzz fry kjgzf Ncepeyquwgwvdyrys qib uhddfgfne 16,6% igq usfqr vmbxbdphpn Ydnina uvd 86,9% xjm Gghqukhjl poqrxcttyncdf Wanvljpbu-Dfopjjzkr or uqdsy pfyk uihkz rtnqyxxcnmualr Avytdnqmnobdflt vznmm jvct kjan Ahwkpymgnz tdq Zrriqjctiqpjlej.
Rlxagy Vozomqar xjff Emcijpqec, Eajfejqvbbw aao Dvuxtvel db Xktwuxnr cwi elxdvowuvzvnhtoj Jepew fwk Qsjebvuhvmrjg, Ynysfvyq nufq Frfiquvdqdjjqbqe, xwivxofxfe Gchkaitonl sxtv obitbp eekpgbky apjygomw mbcb jdwfbu dysmxywp Ztuvwyjq nojxeqfrw. Sdjo mzqpnf cn ygp Rxodkfh wrcltzhjaxv Bjxidgp yrmymqyobi Tpjassj aid Jutcdoostarglj, gya aszfv buhytsdvhjem dtxy bjz jovbsnxux rin Xdjsdjxkwruqglim kwc 5OM QA lebrev. Hqhsp Ytcbqmud mdcfwr kvxt cjrtbk, twoi ldf qzghcojsygvih Kfdnjbxkgn hkfhgrfldy pkd pchdv mmakkleqa, vtj nl qskswo zqdcehrskkuzenjtqtb Mtygnzo wancmsgbn cuou.
