Dunn Labortechnik presents the ExoDiscovery® tabletop centrifuge from LabSpinner which is designed for rapid isolation of nanoscale extracellular vesicles (EVs). Using disposable ExoDisc® -D20 or -D100 cartridges and optimized protocols, the user can easily isolate EVs with sizes of >20 nm or >100 nm from a variety of biological samples such as plasma, serum, urine, cerebrospinal fluid (CSF), bronchial wash and many more in as short as 15 - 60 minutes.
Cells secrete extracellular vesicles (EVs) for intercellular communication, and mammalian EVs are known to mediate physiological and pathological functions throughout the body by transporting biomolecules from one cell location, tissue or organ to another. Present in all tissues and body fluids EVs carry a variety of different molecules including RNAs, proteins, and lipids.
Because quick and reproducible methods are often required in basic and clinical research, the gentle isolation conditions (low centrifugal force: < 500 xg) and patented “Tangential Flow Filtration” technology make the ExoDiscovery® / ExoDisc® the ideal system for precision science and research applications. The obtained high yields of high purity intact EVs allow application of further sensitive downstream analyses (e.g. NTA, SEM, TEM, Western Blotting, ELISA, DNA/RNA prep for qPCR, or sequencing).
EVs are of particular interest both for academic and clinical researchers as they play an important role in promoting or restraining various processes associated with the immune response, cancer development and progression, viral pathogenicity, pregnancy, cardiovascular diseases, and diseases of the central nervous system, making them promising targets also for new therapeutic agents.
Cells secrete extracellular vesicles (EVs) for intercellular communication, and mammalian EVs are known to mediate physiological and pathological functions throughout the body by transporting biomolecules from one cell location, tissue or organ to another. Present in all tissues and body fluids EVs carry a variety of different molecules including RNAs, proteins, and lipids.
Because quick and reproducible methods are often required in basic and clinical research, the gentle isolation conditions (low centrifugal force: < 500 xg) and patented “Tangential Flow Filtration” technology make the ExoDiscovery® / ExoDisc® the ideal system for precision science and research applications. The obtained high yields of high purity intact EVs allow application of further sensitive downstream analyses (e.g. NTA, SEM, TEM, Western Blotting, ELISA, DNA/RNA prep for qPCR, or sequencing).
EVs are of particular interest both for academic and clinical researchers as they play an important role in promoting or restraining various processes associated with the immune response, cancer development and progression, viral pathogenicity, pregnancy, cardiovascular diseases, and diseases of the central nervous system, making them promising targets also for new therapeutic agents.
