interpack 2017: Bosch presents Xelum platform

Excelling in Continuous Manufacturing

Stuttgart/Düsseldorf, (PresseBox) -
 Highly precise dosing of smallest amounts of API
 From laboratory to production without scale-up
 Integrated process and quality control


At interpack 2017, Bosch Packaging Technology introduces the newly developed Xelum platform for the continuous production of oral solid dosage (OSD) forms. The platform combines dosing, mixing, granulating, and tableting in a continuous process. "Future-proof manufacturing systems must work efficiently, be user-friendly and fulfill the requirements of all pharmaceutical companies. This includes shorter development times with less API consumption, a faster transfer from development to production, more flexible batch sizes, as well as the integration of quality assurance into the process," Fritz-Martin Scholz, product manager at Bosch Packaging Technology, explains. "These requirements, combined with Bosch’s process expertise and experience, led to the development of the Xelum platform."

New principle, proven technology

In continuous manufacturing, the typically separated process steps of batch production take place automatically and without interruption in a compact unit. While designing the Xelum platform, Bosch relied on a combination of proven processes and most recent technology: "On the basis of our innovative granulation technology, we developed a new system for continuous production, which also enables manufacturers to precisely dose even the smallest amounts of API," says Scholz.

The Xelum platform offers pharmaceutical manufacturers the accustomed advantages of the granulation technology developed by the Bosch subsidiary Hüttlin. This comprises a unimodal particle size distribution, as well as especially good flow and tableting properties of the granules, and high product yields.

Moreover, the integrated Xelum tablet press ensures easy tableting. "As a result, the system significantly simplifies the development and approval process for the user," says Scholz.

Fast transfer from development to production

Transfering processes developed in the laboratory to production machinery is often a big challenge for pharmaceutical manufacturers. The continuous process of the Xelum platform provides either a direct transfer without scale-up from R&D to production or supports the development process with an integrated, automated DoE (design of experiments) function.

Thanks to intelligent sensors, all ongoing processes can be recorded inline, and the quality characteristics can be controlled at any stage of production. The design of the system ensures that no complex measurement or control technology is required. Further, up to the final dosage form, all ingredients can be easily traced back thanks to the controlled product flow through the system. "With Xelum, we are taking the decisive step forward from batch production to continuous OSD manufacturing," Scholz summarizes.

Bosch at interpack: hall 6, booth A30-C58

Robert Bosch GmbH

Based in Waiblingen near Stuttgart, Germany, and employing 6,200 associates, the Bosch Packaging Technology division is one of the leading suppliers of process and packaging technology. At over 30 locations in more than 15 countries worldwide, a highly-qualified workforce develops and produces complete solutions for the pharmaceuticals, food, and confectionery industries. These solutions are complemented by a comprehensive after-sales service portfolio. A global service and sales network provides customers with local points of contact. Additional information is available online at www.boschpackaging.com The Bosch Group is a leading global supplier of technology and services. It employs roughly 390,000 associates worldwide (as of December 31, 2016). According to preliminary figures, the company generated sales of 73.1 billion euros in 2016. Its operations are divided into four business sectors: Mobility Solutions, Industrial Technology, Consumer Goods, and Energy and Building Technology. As a leading IoT company, Bosch offers innovative solutions for smart homes, smart cities, connected mobility, and connected industry. It uses its expertise in sensor technology, software, and services, as well as its own IoT cloud, to offer its customers connected, cross-domain solutions from a single source. The Bosch Group's strategic objective is to create solutions for a connected life, and to improve quality of life worldwide with products and services that are innovative and spark enthusiasm. In short, Bosch creates technology that is "Invented for life." The Bosch Group comprises Robert Bosch GmbH and its roughly 450 subsidiaries and regional companies in some 60 countries. Including sales and service partners, Bosch's global manufacturing, engineering, and sales network covers nearly every country in the world. The basis for the company's future growth is its innovative strength. At 120 locations across the globe, Bosch employs 59,000 associates in research and development.

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