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ProBioGen Inks Another Commercial GlymaxX® License and Contract Manufacturing Service Agreement on Immuno-Oncology Antibody
ADCC-enhancement for innovative cancer therapy, produced via ProBioGen's accelerated CMC development path(PresseBox) ( Berlin, Germany, and South San Francisco, CA, USA, )
Volker Sandig, ProBioGen's CSO commented "We were impressed by the scientific approach and quality of work which Tizona has invested into this product candidate already, and we are looking forward to combining our expertise with that of Tizona for this very promising product candidate."
René Brecht, VP Process Science and Manufacturing at ProBioGen added "Our accelerated CMC development path allows us to choose clones with optimal product and manufacturing characteristics right from the beginning, resulting in simplified scale-up and reduced time lines."
Tizona's COO, Jeremy Bender, commented: We were seeking a high quality service provider with a proven track record and a robust ADCC enhancement technology for our project, and ProBioGen's package of technical and scientific expertise, timelines, financial terms and, importantly, people behind it, were a compelling combination."
About Tizona Therapeutics - www.tizonatx.com
Tizona Therapeutics, Inc., based in South San Francisco, CA, USA, is a preclinical stage biotechnology company that is developing multiple, innovative immuno-oncology and autoimmune therapies. Tizona Therapeutics, Inc. was founded by MPM Capital and leading scientists from Dana Farber Cancer Institute, the University of Pittsburgh, Johns Hopkins, Memorial Sloan Kettering Cancer Center, and Brigham and Women's Hospital.
About GlymaxX® - www.probiogen.de/innovative-technologies/adcc-enhancement.html
The GlymaxX® technology, developed by ProBioGen, prevents the addition of the sugar "fucose" to the N-linked antibody carbohydrate part by antibody producing cells. The absence of fucose enhances ADCC (antibody-dependent cell-mediated cytotoxicity) activity for antibodies directed against cancer and infectious diseases. The GlymaxX® technology is based on the stable introduction of a gene for an enzyme which deflects the cellular pathway of fucose biosynthesis. Moreover, GlymaxX® cell lines can be two cell lines in one: They can either produce afucosylated antibodies, or, by adding fucose to the medium, stably produce fully fucosylated antibodies. The GlymaxX® technology is universally applicable, simple and potent, and can be rapidly applied to any existing antibody producer cell line, any new cell line development or to entire expression platforms. ProBioGen offers this technology royalty-free to third parties.
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