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Polyphor: Global No. 2 in the 2018 Antimicrobial Resistance Benchmark published by the Access to Medicine FoundationAllschwil, )
The new antimicrobial resistant benchmark, funded by UK AID and the Dutch Ministry of Health and developed by the Foundation's research team in consultation with a wide range of stakeholders and experts, has assessed the extent as to how pharmaceutical companies are addressing antimicrobial resistance. Among the twelve biopharmaceutical companies with priority R&D projects benchmarked in the report, Polyphor reached the second place when comparing companies by points earned.
Today, the World Health Organization considers the increasing antibacterial resistance as one of the biggest threats to global health. Antibacterial resistance has been estimated to be responsible for some 700,000 deaths globally each year. In some hospitals, the incidence of multi-drug resistant infections reaches 30% and more. The scientific and medical communities as well as health authorities around the globe are alarmed by this situation and acknowledge the need for new antibiotics with a novel mechanism of action to overcome resistance to standard therapies.
"We are honored to be selected by the Access to Medicine Foundation as one of the leading companies in their first Antimicrobial Resistance Benchmark," said Giacomo Di Nepi, Chief Executive Officer of Polyphor. "Antibiotics' resistance is a major challenge to public health. Our novel antibiotics, the OMPTA, are the first new class medicines against Gram-negative pathogens in 50 years. We are committed to rapidly progress this class, and its lead Phase III product candidate, Murepavadin, to tackle the dangerous rise in antimicrobial resistances."
Polyphor has discovered a new class of antibiotics against Gram-negative bacteria with a novel mode of action, the Outer Membrane Protein Targeting Antibiotics (OMPTA). The most advanced drug candidate of this new class is murepavadin (POL7080), a highly potent antibiotic also active against multi-drug resistant strains, which is entering the Phase III clinical program for the treatment of patients with nosocomial pneumonia caused by infections through Pseudomonas aeruginosa, one of the most difficult to treat pathogens. The next generation of OMPTAs are in pre-clinical testings and are broad-spectrum antibiotics which target most important Gram-negative pathogens, including extensively drug-resistant and multidrug-resistant strains.
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