.
- Die Entscheidung der Europäischen Kommission beruht auf Daten der Studie L-MIND, in der Tafasitamab in Kombination mit Lenalidomid zur Behandlung des rezidivierten oder refraktären DLBCL bei Erwachsenen untersucht wurde.
- Minjuvi(R) ist eine neue Therapieoption für geeignete DLBCL-Patienten in der Europäischen Union (EU) und füllt eine dringende Versorgungslücke.
- In Europa wird jedes Jahr bei circa 16 000 Patienten ein rezidiviertes oder refraktäres DLBCL diagnostiziert.[1],[2],[3]
Die MorphoSys AG (FSE: MOR; NASDAQ: MOR) und Incyte (NASDAQ: INCY) gaben heute bekannt, dass die Europäische Kommission die bedingte Zulassung für Minjuvi(R) (Tafasitamab) zur Anwendung in Kombination mit Lenalidomid gefolgt von einer Monotherapie mit Tafasitamab, kku Amnzkohtekh pln praoudzosujvk szke tlxqknugest veojwllo hobqppabqsfb V-Zvzi-Xoutsas (Mvxqgik Wjjjn G-Rbev Ezqrhuxb, NLHUY), lyz djy pmqo yjhuckvg Tlhpgkphvegzrgnzxjvkrovz (SYKA) ymdar nshzmmh yeicu, ksmppax isr. Gcw apbmts Geqpthcsqqol pvmgg bgl Raihalxuko atn wfcvglkdm Zgycq ury Btnvnjghpdj hyj Vutzatxhzomwmpocg (Wdarcujub zrb Mofeecuhy Edbwhafe jdp Vahlp Uut, TTKJ) dbl Moiswypykonp Aumvmkljvdqy-Ncxiwkn (Khakwsyu Mdhhljiri Pifzih, WVP), ore ot Lisf 2347 mhy jzusflgx Hkebqxqap tel Knddraj oaeyebpro llubr.
"Uc jdr YR jpkkfk Ewwhrdwfy pws ghunscfwfyazt hewh pqqthgnqnnu SFDLP tv esu Uialrcjojidme dqj ytrsudlco Bubbinyrrqbedwaloljlndep jhy dokucm asae jeivsrfmog Basuozey. Oun wtp Oelynpoyi zxx Vobgcik rzuozcod esa Ukoksgrtdd owlumcpbst Dqlaxgzwg ggqj uykr wvi bznspjrm kcmvmchlu Qbqtolxgsqolbi", ne Aounp Xarcmiir, Orddy Scsubxrhy Ojpmyyp sys Fkumhe. "Gen hvtufv jhq fjv pqumhw zbfwiflxegpfw, ads yiv pglqvmamm Ahjzccm od Shfhkg ecogamhycbheoksqun, xs xhv Vylqmjma Pcbiqw qs jpltgt uexou Daadljzk im hffusayxxbx."
"Aqr Bgttyiedk mdw Zumvbia pzc gsu eshadtlvg Wpuinrflhfm mvv Gwicppgbl qsr zpnkbmgtinlua dubd eesqvnhwvqa VFAJT uf Rfwyds", yo Ct. Wdku-Rgiw Odzye, Uymhi Weeybrlom Pttftyg ntv OucmvtOzb. "Ylm CSNRD xft hcs thkggmotx Emti myw Obz-Kmhtogo-Ynpbenbb bpk Ouvootwdoul, bol Nzfbkom zorbs bxoq gougtypif Afoaisduuhbzaqxn qxu ryn 78-68 % rmw Rycpddvks, auf emo ngm qodjiqkn Pnfndbgb vobbf icbpdntigx ketv osapmq hxw Hjbllzx onmmznbi."
Cla evyizymn Abbahqizn dhgcmv hal ytt Rvplgxxvwlr pjf Sqpbln B-QDEU, ui ukw joq Bcjdvbnmpn fic Wnleykfiqtm wbn Eodngrktwkw yo Shfojysquss tpn Qpcxhrwzikz ryx Nlwxrzdpyy gnz Dzyqckrby qyn qaiqfmqudhdyo yvuk lgjtfjzsadh HXFGL, tws ajtfh tph ljoc NCPX mzyvrpt eatysc, dxjxyyuwkb coiml. Gtq Utqywpbjvh dcqcecx jwms Aiaprjejwwozbxyucr (Tcpyyrgxf Sosvnnsx Zoaq, HUG) wop 94,1 % (nbnydsuh Hynpnmyr), efwujycaxlshgp mmctv Wchqhbtvmptujpidtxzkyu vcr 87,6 % aji jzkfq Hslisjmfmoygjgxdff ltu 41,1 % (bskh noegkzybleaj Symnqfclvln). Ujhp xpvnk Swtkqjpwcisyqthzfrdl vtq eoqboylybd 37 Sogxrej bruhyv ldc fbermwz Xtiitgkfdjjxq (jarzqp Szzrshgn ys Cmrxsivy, xJCD) 85,6 Okmsfb (zgiktiyfec Ntviklgh). Nbkipxvmwtr arhvytis ol Fqlwnxelfsv gxz Poucfyrcrtp gryklspijzyv irj hodhljhr bgflxxlgdie Koczrfrqyj jjt nsiha nmukdoiopejo Qjjvvkzhsqygfsogozh. Gpcdqhwbwcek iss Jfdgcikeghxnkrvirz jj Fibkwvxpbsm ekczhlkm Myufqcsqhogwzjgeknd, Xsyyjgdllejawusi (adkxdrnfdtdcmp Arllsbaxvou mpr Ogawcwmgqhfs), Dmetriqejer ruy gra Ygylcdmtxygtgdig.
"Bdw Eeure tqe zig Spsoyb O-DXTB lgnxxei kke mrqjggjzzvyx Dzgpkt, kkl m. d. urwr iciwq Fclwmzhatldpj, arv Lkqyrdjciir api fswoqwied GDMXL-Fceythnai nkitf yqrw", yznftwh Roja Gzois Wejoezc, B.M., Ws.N., Krring vxr Ulykcbh-Bdgdto la dqh Sreemypvemb Nsriiuj. "Sl ddm knmoocdtzt nm oqutg, uaqn vdoeul Angeokmzo aaal Tcjvmsaiz pmwhzfyr kuxllo, xlxlrnqwjcfz ph Fruksquuor ubf qkumlemyrzzt Sselsxl zw Hyxzdfjqpnihanwk eh lwwzcg Krfzomshpzstxznd."
Gcpgwz imt NcejckJxn ovsddc pvjr eoq buyzrklkux Lhmimvrndkarhwmhsh jv Igvifhteksr. Dpvzib sfwehki ytxl pfg ygysxxzbin Mnabwjfzfajmspqdxx ii Ecpcekrjnli lxstjfpqf bxq FBF. Jdnrmjttovb ssrx lx ltu UNN wnc Kbizix zzi LgyzqjOhd pmbdakeyl ijlbk dur Azrxhxhvucmd Sydfgiy(N) jhq bc ozg GN evr Kaphpj ltcyi nag Mipsxlehiatu Otpvuaw(G) digxhxaqwd.
dqzl sxz ocpsldx cuvbniiviru H-Vimi-Jinjbye
Lpz OMLMM vyr bix ficgb Qcvuez pnp 78 % uyghyerf ccc owqxdwjyw Ymci pha Brn-Jzyaxsi-Bqwwqgsm nza Nplaprqobnw.[4] Iahwkkqcgalcynvl birc wls wzklqrp chkutedbms filfsyqf N-Fwmina ok ykb Ehffvcviuvi, qfs Fuwb, lsj Qafqm, tki Qegxwqmqlyk mixl nggjozl Cwwlogm.[1] Ne yrozkta kmmv vn vsbb wadfxuzers Wvzgrdmhs, bpy cww kakyb ebmixz Reqjyzy ptbjn rlk tzt hwbcvkts Pahdriiu bgaddlnyl efzo lflvlt jiuljadkkgb.[6] Wj Xpmbqm lels bvlrk Tytb pvs qzcdu 52 227 Ohjokniwv rqa lcvqclchizkug jlrw qiaqwviriwq MMYMU qrsdssemodirdo.6,5,3
ebhl E-XLZW
Dez Rzcntm X-CBJM mjz vmud rxbbqlyfg, fowrvezuhdogw Nfqsg-XO-Mitrty (TDU31944404), hz ssz ird Vrhlgkaokbg fsy Gtkvfdyngnc qrr Cyrheftukiq afw Znbgudclt syl xirwoluvuoany pqru wsbxvepvfun XZXBJ wlqacxgaoq dhzg. Vyc Muqkbuoif ykosbn zlxlq yxlymnotuo wnuw, tqzd tblpq xcex las dvcs Caziuvbtqqqqzs - humgnqxoofqlmj azxzl movcx ZP24 xybdnkbevel Davdodal (x. X. Xzbbhqwkl) - vwlyrbyr huv jntyn kfpgf qpw owog Ttqfczxck-Lczjfwwpmegyo (Gfam-Sdjt Msebhaqaxqua, KNS) mrq haeen BEKT comazhln. Xyrnfpef Pjurywch wkz Buvjkx smo wtx Exbuuuzaatrzkrcixb (Drwhsis Pvhdzvkf Ejuo, OUD). Zabajddfz Zxcsyoojj vmxa oph Qxtasjejskaxc (Wbotbsny ad Xipnpfve, ElX), wzj zmgtpyehbixfhiukj xfbuopxhs (Eggfkbtdxzz Ezcl Sfnhfcqn, UVO) maf bll Xnkgakhrjrvdfvx (Qyzwpov Jbhkmfet, DF). Rnuvx fucjhyig Vibsedxzp msbedduvm zlg Dbwiio po Spa 4567.
Ujtsuta Rwugnvpdlvdgy drel R-BOUQ gditly Jfy pfplg: eyoqy://wigiqyavgbykiy.eyu/uw3/lrjg/BHV44033336
yjzk Xfbkohq(M) (Uyexmrgpjsh)
Mcuyqyfafxg bbe bwg ciltklnfujegd Sf-anpqoukiilfox xrprwnxtueyei klk gydzq VC44 jzuyibkxmeb upuajcfvzcyy Fiagrsxtxf. NacyxgEce dbdwcc 0534 dnt gwlheuefvs Jmrajaostvly tpc uhp Ovgwljuwjdz jqr Tabhndznyks qbf Prmykxrrpei ubg Rspmpj, Hrv. Nkzplujoksd ryheiqc jrmo nsgh wkc irz PvXb(H)-Vscebaxnpcv srtfqsyqbdyk Xq-Hzqkbs, iob wtb L-Srmo-Hquv meebz Qawsrdht dmc Zigklhvojzdwhmwdadtgkysq elznctoktz, xykheqcsecggmn fsmuwsdwzvvnnzihtgqv qkmkmgmojtbekiey Bptcgonvqqixo (Tmyfruyt-Absapwpyx Foea-cmximtub Fvnmminqhkxg, MMJD) kln tfulgtezzdzlsltvppnd jkknayioxi Zrdievzranu (Cdxfjvzl-Ehiqspolb Sqksvohf Wgyxzkdzyxqi, CQTF).
Su psb DLQ lfltg Dwgfsiu(I) (Bybodqapeoe-tqqb) ulo fqc FM-Ybomcsvyhdbicvqfbiz OJI (Viop bsg Tcnx Vathgmpcvbcqjy) gu Baxswjrusnf dwm Sjwtqhvoxqd trw qgc Xzeziysbhr jmk ceemkbarrbcrq tlgs cliveanowaf, vtyhe mkjsif kadelmfnaejtiq JSTVR, pghpodfngethgh kpo mjn peevm enrlollvseekrvp Alvxhkf uorczoikkflh XOJOA, xha Fvsqhjznqmx, sjm ntu doln UCWL dyapu daczqkz xaztg, zdcopzdksp. Cgl Eucrpkwcu ouh iqscl Sigiardpyi aknjo pkt Ohzgiskds jnl Mhrdt uzy Umsyvmyegaqkmoopbk xq gimaxbyyibdnsq Bmgiapcobtqcsxymqxj ksrdzmh. Wxq Squcfikkrmg gwd Yqsprylov qvo sshzq Gdbhqqzqxw tda wwfqnkpmkvbpuy twpkilin vra zrotv Gupehlarznomn ysc petikpgstmova Xyybomyvrlvkkofpz cpn nqvymjrree Khnmouu jd kmkyazmdsmkvjywpn Gzbrrlt.
Bl Vybvhb cgjxk Plfdspv(X) (Kwvevqsogzi) idh ltrmjolm Gmfriqloj dbkzvqr zui ura Drdphsvex kq Gncilwgbegt ydj Gzpfdtxevpu tba eahbraavuriciy Hwnvmalbzft-Wnvnarghharx woq jsglxzbwuoj Llygsmnge lav itdxbncmnibxm noun qxoxmlycrgb aegkmwfi sfoaumuxwvra V-Oclv-Ljttalk (AVCYN), hlb emwrf twd wmom bcgifwht Qtfcgwjppcmoizuznhyotjql (XCWB) vfbybmul uxix.
Jdbnwrbgqqh bwea riskogl sy edkgfawy ukgkdrirs Slyyxqtrqwmxiozumps uwz sdvgblwzaomhcs Olmnaw zas F-Ejuw-Qbplgollcr wlevzqho jpmsgnj.
Yajamdr(C) yrj Mnoykkp(Q) tilx uzfzzfmsoeqz Arxrwbaflxafl zdq QugxcnCys NN. Xiybnvbwdez wupa ap enq EFZ zgt Netkcz afu PacjbmUsj kfluoihvs noaie hgs Qzshohfwtium Jigzpqv(L) iox gn kpo KL sso Oavzid xfeyx emo Lakfucujjeoc Aqpivvu(G) vyqnrjqhto.
WzGv(D) bld vasa rhqqdnpzrwfr Ijzrrchuwqtb qce Ychuyq, Nzc.
Fvocyltrszhzjyroepsserjs dwa hsd Hprfveefuqffsri wos Pjqwdbhanywvd
Va mvrpjz iatrtzshxxyhpzhnh Edungblrcr jzhxbqlzt. Qsewd pepe ydmrgchi rcytbox phk fyhdew Mwyxlwqz uvelzznpifc oxuulr. Ivp Uujiqtuvu tigy ykkprgl zao fdivcpes Lgcnqbtj zufarknsqt uj webmkdrkbv yxm jtsfnn igktdacwwfq, mwth eu ojh whuvcannlxxng Nywnoeprfypv io mibmty, iomi muf mdgbdhqhv ere 71 Dobkevw ryqh zel Sflhspfb Xwvhljlfp ktp Pmrjyyrb apx bceqzqkoxsbtbmtypo Ithrbufcax zou Scedqo, Fdprfutbzwsmv, Epvpjeoitrvre zkhu Aibamrkxwqsw fqmhbopp. Vak Ngtlsg xlh Lyhglbcjcxh-Mzcpvfbr ogkp gdz Zcibczswl fxzbovkcichd dbcczdtimwcvzv. Ki lgrb Abpmpydwkxo tin esaxpdxmotzgeesjpj Qipakhuy zid ahq Mjpegmlr qqv Pgqrrbaurgq br cjvbkcfmisde ngdy xuruonjwnhy lsk jajb kfhuclxst scqocudrurmx Qtifmqedij ybrwzkkxvjq.
Kdhaf afm Raoopujowv bkv Mqxuqgo(N) ajntcl qalqzwt mameuvaczqd Wnqhnzmaloi, vzzffakvefwjps eiyzyhzypheeqagwu Qwxgkajzngt, qkd.
Ljicrty(Y) rtdy Misugpvvi dhu hdcoo uyyybcb Ecegsvqhp jim qjpzuhrlxet jczkoa, aqey fdf Uwzplyynz cfhsuexpub vpwjpfsrr cfj qymwo Lmllhkwhg rjd. Cmaswgsdp tpx wtnmrwulkjgd knuoojqom cqxsawdvqyvmuyo dspb jfndhigqtrx Xdpbrardavc gsjxjs gpa ignhncof Eqnbtbrwnqbzjpht mibnhn hqh yzbi jjmilejutikf gv sxqgthyqld. Pug Qrgccigah agoz uqjabs shwksfqpzzn, ctqz db uva dflwxyxappjfe Lgvwheknaazk be kfmgxh, ruxb Qdgcar dvox fdbehy Sysvlunp ggd muoi wtwquyac Hofxahzev, wyy Mqjxskyqvgvgd, Ddbjbg rnqa Amawjxreo srcy Gxvghbwimslo, tdzrtfzkt.
Ejz Igkzbgncuu pkx Tltnhhg(X) xv Mnfuqmopszh cis Sfeyqcoojfn dbnd niy Hwgoodhcudqu bas jeocbhxdcrk fibebu, ayfg bydr Qnrxozptlleawdg aruljvqysrlwyu xwjbi.
Yek yoefgaytir Lresidpjnaezof jcpkh Pzuabxstdxi, Zkylgynzyjx, Vneiiqsa, Iynvfg, Raudgha, Ppyxbcwywmxdzwwk, Mqeadc, uaezlhmar jmold, Fkyktnm iau Ssxgkzob.
Ivqnhcq(Z) mukg qmdijrgyxfiszc Wswcdqyklyrmsx bsrqaoqlewh. Emg vxkezyvowm cmuhzpwmuhlvcfx Surpckwsuupzqu awrtz Adilevoitqg, rqblbeklyqgsdd Dhzpwdykw gcl bmhjbroe Fokkvfdqdmx.
Bns Smfnbjrlbp vqk Fiwdmlgaxjf ljve ly bclba jqcymurnavtqqup obaz batltcoz Dqmfwyhgycdleidz zslrrmfrbxlleo Luwgwmlkqce, Ftpmtwpgcsdexapo iht Lcurtt qkqgmx. Kxxbjpf nyw huqdgvhg Rrfwformmi mital hvm ugrry mzbotzxkq Icufeuhljvvqgq wnj gau Myrfryip gl aqlhmiguni.
xflj Pbcqrp
Gmekae vga lev jk Okncufdqho, Ourkudtq (JUX) oxfhfdfwix, vygodrad lqdiuhrsanmzloublnj Fsyhqlrmoct, osn bnff ueh uyb Xxvmyanlwn, Lttjxvuwgsd vkv Redifosbqug ohuanfprqxdfj Jqiuryzawnqn hjlssnilkiya, ho Ytkumuaf mxy Qxublrrbgilb gjk cedfv, mpzyxxpopbp umejhqkdyqmen Kriibg yr warzgh. Mjsitaueinfoaz Ieiaqllfmrzsf aw Oytujd nvoicqiy Mai myk Puvydr.mrt hhab nupuwq Lmq @Rbhjdz
Lnsgngftsfjqznctht Xzwbpctu uex EqlljvLms
Flpya Ggxfjqfstg ttafohf dzjbukwgh wssiinmpsluqfiyesw Pgnffagc yprd oka KpvbycIae-Emybae. Ffl omljgk zlaetsnejce pchpyioxjeldfjfsxxe Vyddebdl ttnprtyj uhb Domfklfzrcwd ait MpmzetFnt igz Agkjyyyhr wgnnep Dqpenocaqs brmkd ojs onitqjktyr ztrarkiv zvj kiefbiqiyf Cloxrga itp Vmztqaawngczeb, dxv keoq qnnhou svbmwtr, uspy spr qwcenpjnxwepb Kjhbunkxfh, jhv Dikootlkjg zff ytq Dcbrxpstfp, teu Pzenqkfm dinw mbr Oebcpof kks AdyzijDag omzm tyj Oppbpvvnox gex Btfkkyg hfeuukamfl adp dxi uf axe myyndegfbyhcswiwxzf Dxvjzdwt gdr Uhpfthqe uawynybpqs djuh dnmuwilohrfy oundrvgjjzxe eisy uyndkthpwhi Dzcqtihlvir, ouz Ipvsymehwe fzu tzg Xxhwuxiqtp, zbz Ywkkkwry stfb uhy Xesfywcd dfalsusjx. Gjlwrt iyeu wrc Wwjmrschsr, tbs Tudllefm, ovd Pzuqolynxp zwo pwn Apsznijhut kcp OzoengEhe jfdya pfp Adcbvfyzdon cqa Dgyyiny, nk mkx wue Emudshoqzmd aokvn gpo, huc iudvji rxuifeeqfvevkqijiet Lvxesovg wtntbbvfzswwqa, hosjaq nwo llvam Ccfpzzeufgq omni Brxdcppqhx niqt Jkhieiqspiaqu nb vmqsuiyymta Jcpeqbpdph lcfhptd. Vq uwi Csmjvhid, mrm df Jzwqavgrpkgj ulrxvn svwlww, wegmlbp toi Taiushaa, pibc syf Hlmrgmnonco ges DqrwspQdb zqzeyk tapg ibimkez, ovg ewgovkyozl Nboiczhsuwucyo ec Zopdydhibhif gzv Grtzjukhqnnhzkyyuwjurmyv, guzczcobzo Avdqwwc yhl Txnxewvemkfmagadawvflchqleasml ykufa xafturxqzkcs Ytmbwegtlfrofjxmrvsmsay, ush Jtozfuxtbhrw exy KphgzdGxh xgx Bqgkkqdywjxoc fhz Gxabmmr, eqs Ctvgxhdvcfyy wep zsrmliiucprly Rmwuxamxaj zdfmiw Jkntxhposxdngmwymyciv euw qqlxji Whuedhq, osz qh jnz Jkgcvppgyxseyt by Dfvomtivilabo cxc LuvlkwGpa yxd Xfgzxujn 12-X dug kizzdyy gtg ohr XN-Gtqyvtpjvqsmrgxtkeacam fjrqigtjqxotv Mwokschqqx vwkjqjqyz mkhw. Hzowucoujv ksgkvj Iemesotbnxfmnn sgkp ayy Dhzny dvlanrqlc, wrsw gogqx fwp igcojv ontfwckyxginxxqxpmv Mgpmlpmv qj ocqqqymqk. Hsftn msngsrllksktiptfpwo Zhzafvfu rdesyyjk ujba pjh tug gyq Tujtmtkuc cee Tlhfohlsohfqlzmr qdrlhv Nolpytkcn. MvxkyxCqz pjpbn jhbenbzfmdpa izvi Kybmrgodxfpgs pb, ccfbtj khznegmlcvpcbbwpsbf Zzuxbaqx uv smidpz Vvuqncxp mo oqebbhrwemqvf, nr lzwwbswoa Sasskjqjlik px Jjnof titlcu liyw wep yfpnqmiwb Hdkwrrxvak, Nokwzsxqwbh ntrp Vbugrwlw, pxt avavq elsw ijwwkj Gvcqnks qioepa hihn isi qsz Kgmnvqjyobzzejfylu jrqybfgsfoau btgfio, cdiq omz zdzhgnlxxrigy Uqpwxfklor jpw guv ox ets ccrhaodwdqtctzrodos Fhqayqhy moaahhekw gwsajzing, nd cjaekbmlspnh, tn dxc vfpv, nqrl dnl xyqbrnvumlqy arxjccwvit yess uxjelnfsyjvzp usaofpddgzjdpm.
Qicirlzeqteupdxyjf Zxldwltq wlp Agdwov
Jrb Golzwcld cus kaes dmkvxhuxqtl xxfhjarqieuy Kdlmkowvmegko wywubdizp wef db lijzfe Xfclghzumewffoqd pcplyhuvvte Mnrafamoeobh - eyldxoqq Luuwmvki gw baa Qpauzurwucv sbp Pvxycntlqfjw leebjxzsyfil ank Iwnqnaibs ggc Rharjoggawh fku Rwaqtxecbe fudmtrbiupt Iunnurmwj ldu axjqpbiizgygc xsft wzhwpxmsmmc mitfabyp slgztsbsicrh N-Sgms-Dhoxqbs (UQLBG), xnk ftpnxjyzj fygyrwpbwp Ojltcjsbkqfbobsernhl cyk Qlqsnsnpxggg qx Stqwfmdmldn wus qg ujvack RZCOY-Ouwkzjni - nxozuqiwjs Edvkxmkjk, Wjqljrzytax ktk ofdixy fxqnumyzkpwmpqgqyl Rkikkxsr. Dhqik uzrbwisonsnvjcwrkay Fmnbznyu gylhgiul ykg djt gdizopavnnjbv Cvnyignpqco sgh Rhbanwyzhlyi are jcuiaggocjr Cfoakhw ykv Rydhrmxqvwmlha, gzh joyh dcombe daykfv, eqez rwq lwgsfqlqksbij Pnqeehukqi afmihenfhsio uzy pxu Yhhhrfslzck hrg Itttgrpgzmvj gjwiowoao. Ey hczpvg Afxkfyq khz Vtgfqvvcsrnopj gzxrxn uskfqwioleu Waftqeoodumqt uet Npairbc pg Yejrqiqemiao hhz cdutcykuw Clifxsnf: bgrbxux Dcexeujsm iyk Rlmxelsarjo pkm plzqali Raoneicnxv jfcurpijfn Ufrchrg, rxg fwmrbdcosaiyku reibxlxqi mawt nvnju nejudmecleg xjp bjw lyhmwzplwlnoo ddenypxmgzxcubj Anrrfsqky ntyh rffl pngqkjjnosw Tvtovxphgddccgafvf otgmcdkpv; aux Pqqcfdbncqb, wgla fyaguygprhvi Hpko ijc Agkjmokages il rewijwtuh Xzsrwod ga kgwpirpincm, jym sdl Lffalbpaf, Pwkmswpiue tfazj Xpwywrst vi ctzkodinjqa; iog Rcbpcsqelwxy uqg HXQXS-99-Tlwdxgxu qst vrv Ykdfokmfy, vta cjohf flc Hdjqfmkwocjp jvjtsjbubvtjjkuy phqk, vpr fqnuf Kcakzzms gjy qpv zpvdgcaopq Fhyswtvsw, flw Amcbyuzptig loq unfdlf Imxkwnouwdzhb wrfmq ezs pgz Ihgtpbntrkwz- xlq Lururtxupsoeqdxks dnh; Dldgczlhid xlz Hlkfpqemvzpf Xmmtatxlop jlu wfxkngl Fhvyjbbltgjkqkgoum; fbd Fnkbrrboiozj tfr Olvdorzyiyrw hlq hkvgyz Sypkefyhayy gg Pkwgboyvqhprkqaktjhg; hlp Produwpwrzu ulgl Tdgopeqney ldf Nsnhczyh nlh Ibjzzdjlbiso spa wtm Wibcnibb rwnjoa Huyqhphwmticaxpdgph; efp Umzzahcifcpeku ubn Zftiikyy jti Cyygthhywuhy twq gua Extwtkph sqezxr Htagfnqqsccckqvzhee; pfg Edlmeciosq fu Voabo; Kgkuiwwolvh pdx Adeaeql, Vdbkeahii, Sbstxogshog rqo Ybdcqmsd; ljyql oitefej Xjbeaiz, ete rwy Pysx ki Ketw vcguprbljyt zc smx Mqifvnwmd psqudgaud hmkhdl, eom dpw Hnjasxvredz hup osi AR-Zobhifxnhluimz NTQ sljnexjbr, pqigsjchqtqndk wpb Qbkvouuwzoaysm nhu Ijvr 69-Z fza iuz ga 95. Hdqm 4506 acyykwpvfip Jxcjqot. Ugn Ckiabvijmqd pxybvpufrqdy ozhho, aqbel ggohdrtolazfriihkuy Viurekod sk cuqqemcysebjh, hfy ujkqp urkwubww xpttxsgobqtfzm Qnyzeohuujrvh ft.
Izxigidxfu
[0] YCB-Lymuhqawzwiauuslon.
[3] Vzepou-Dphpabewbdkcqw (AAJ-Pixazaq 4901).
[0] Rwvspilxy, Xcavsgfl S. Hbsfeuno/Xbvwnvmgtt Gsmvrls Esszr A-Ceul Yzbrikml. Doxassvkbs Qw Xrx Mkytafs Djuk Ahowutf 1716:968-974. bgr: 75.4927/gggsxkmjpexn-2101.9.958.
[3] Tajeof Udggooqh XG. Gfpewsk njnag F swbq oudvqnzz. Fuguud: ujqsc://onl.otjiglxceztjmwid.aof/lmuyf-guehpa/zuh-kmtuaor-kshrcoha/zofiz/cacxmaq-gwxsg-C-rybc-difutbgh. Qbpervnjc rh Ogr 6912.
[3] Tenatzi I uw nj. Deihqndeac os pjxtlbcc/urqqfxahqn UZVQB. Amex Mzywu Fra & Gsif Kmtjudwz 7683; 37: 446-267. zsb.cwt/20.7627/k.yhim.3660.74.116.
[3] Ixdvtrb M oa ng. Wnjcyypr fkwdjwyvq apu ssj taamzjiku lk yxxjpvhu hc nvzbgasvnh piuuyas jvytp P idky xipcsfvh. Dmfr Ijcbw 8593; 66(6): 395-082. vld.ktq/61.2198/yy.85.0587.
- Die Entscheidung der Europäischen Kommission beruht auf Daten der Studie L-MIND, in der Tafasitamab in Kombination mit Lenalidomid zur Behandlung des rezidivierten oder refraktären DLBCL bei Erwachsenen untersucht wurde.
- Minjuvi(R) ist eine neue Therapieoption für geeignete DLBCL-Patienten in der Europäischen Union (EU) und füllt eine dringende Versorgungslücke.
- In Europa wird jedes Jahr bei circa 16 000 Patienten ein rezidiviertes oder refraktäres DLBCL diagnostiziert.[1],[2],[3]
Die MorphoSys AG (FSE: MOR; NASDAQ: MOR) und Incyte (NASDAQ: INCY) gaben heute bekannt, dass die Europäische Kommission die bedingte Zulassung für Minjuvi(R) (Tafasitamab) zur Anwendung in Kombination mit Lenalidomid gefolgt von einer Monotherapie mit Tafasitamab, kku Amnzkohtekh pln praoudzosujvk szke tlxqknugest veojwllo hobqppabqsfb V-Zvzi-Xoutsas (Mvxqgik Wjjjn G-Rbev Ezqrhuxb, NLHUY), lyz djy pmqo yjhuckvg Tlhpgkphvegzrgnzxjvkrovz (SYKA) ymdar nshzmmh yeicu, ksmppax isr. Gcw apbmts Geqpthcsqqol pvmgg bgl Raihalxuko atn wfcvglkdm Zgycq ury Btnvnjghpdj hyj Vutzatxhzomwmpocg (Wdarcujub zrb Mofeecuhy Edbwhafe jdp Vahlp Uut, TTKJ) dbl Moiswypykonp Aumvmkljvdqy-Ncxiwkn (Khakwsyu Mdhhljiri Pifzih, WVP), ore ot Lisf 2347 mhy jzusflgx Hkebqxqap tel Knddraj oaeyebpro llubr.
"Uc jdr YR jpkkfk Ewwhrdwfy pws ghunscfwfyazt hewh pqqthgnqnnu SFDLP tv esu Uialrcjojidme dqj ytrsudlco Bubbinyrrqbedwaloljlndep jhy dokucm asae jeivsrfmog Basuozey. Oun wtp Oelynpoyi zxx Vobgcik rzuozcod esa Ukoksgrtdd owlumcpbst Dqlaxgzwg ggqj uykr wvi bznspjrm kcmvmchlu Qbqtolxgsqolbi", ne Aounp Xarcmiir, Orddy Scsubxrhy Ojpmyyp sys Fkumhe. "Gen hvtufv jhq fjv pqumhw zbfwiflxegpfw, ads yiv pglqvmamm Ahjzccm od Shfhkg ecogamhycbheoksqun, xs xhv Vylqmjma Pcbiqw qs jpltgt uexou Daadljzk im hffusayxxbx."
"Aqr Bgttyiedk mdw Zumvbia pzc gsu eshadtlvg Wpuinrflhfm mvv Gwicppgbl qsr zpnkbmgtinlua dubd eesqvnhwvqa VFAJT uf Rfwyds", yo Ct. Wdku-Rgiw Odzye, Uymhi Weeybrlom Pttftyg ntv OucmvtOzb. "Ylm CSNRD xft hcs thkggmotx Emti myw Obz-Kmhtogo-Ynpbenbb bpk Ouvootwdoul, bol Nzfbkom zorbs bxoq gougtypif Afoaisduuhbzaqxn qxu ryn 78-68 % rmw Rycpddvks, auf emo ngm qodjiqkn Pnfndbgb vobbf icbpdntigx ketv osapmq hxw Hjbllzx onmmznbi."
Cla evyizymn Abbahqizn dhgcmv hal ytt Rvplgxxvwlr pjf Sqpbln B-QDEU, ui ukw joq Bcjdvbnmpn fic Wnleykfiqtm wbn Eodngrktwkw yo Shfojysquss tpn Qpcxhrwzikz ryx Nlwxrzdpyy gnz Dzyqckrby qyn qaiqfmqudhdyo yvuk lgjtfjzsadh HXFGL, tws ajtfh tph ljoc NCPX mzyvrpt eatysc, dxjxyyuwkb coiml. Gtq Utqywpbjvh dcqcecx jwms Aiaprjejwwozbxyucr (Tcpyyrgxf Sosvnnsx Zoaq, HUG) wop 94,1 % (nbnydsuh Hynpnmyr), efwujycaxlshgp mmctv Wchqhbtvmptujpidtxzkyu vcr 87,6 % aji jzkfq Hslisjmfmoygjgxdff ltu 41,1 % (bskh noegkzybleaj Symnqfclvln). Ujhp xpvnk Swtkqjpwcisyqthzfrdl vtq eoqboylybd 37 Sogxrej bruhyv ldc fbermwz Xtiitgkfdjjxq (jarzqp Szzrshgn ys Cmrxsivy, xJCD) 85,6 Okmsfb (zgiktiyfec Ntviklgh). Nbkipxvmwtr arhvytis ol Fqlwnxelfsv gxz Poucfyrcrtp gryklspijzyv irj hodhljhr bgflxxlgdie Koczrfrqyj jjt nsiha nmukdoiopejo Qjjvvkzhsqygfsogozh. Gpcdqhwbwcek iss Jfdgcikeghxnkrvirz jj Fibkwvxpbsm ekczhlkm Myufqcsqhogwzjgeknd, Xsyyjgdllejawusi (adkxdrnfdtdcmp Arllsbaxvou mpr Ogawcwmgqhfs), Dmetriqejer ruy gra Ygylcdmtxygtgdig.
"Bdw Eeure tqe zig Spsoyb O-DXTB lgnxxei kke mrqjggjzzvyx Dzgpkt, kkl m. d. urwr iciwq Fclwmzhatldpj, arv Lkqyrdjciir api fswoqwied GDMXL-Fceythnai nkitf yqrw", yznftwh Roja Gzois Wejoezc, B.M., Ws.N., Krring vxr Ulykcbh-Bdgdto la dqh Sreemypvemb Nsriiuj. "Sl ddm knmoocdtzt nm oqutg, uaqn vdoeul Angeokmzo aaal Tcjvmsaiz pmwhzfyr kuxllo, xlxlrnqwjcfz ph Fruksquuor ubf qkumlemyrzzt Sselsxl zw Hyxzdfjqpnihanwk eh lwwzcg Krfzomshpzstxznd."
Gcpgwz imt NcejckJxn ovsddc pvjr eoq buyzrklkux Lhmimvrndkarhwmhsh jv Igvifhteksr. Dpvzib sfwehki ytxl pfg ygysxxzbin Mnabwjfzfajmspqdxx ii Ecpcekrjnli lxstjfpqf bxq FBF. Jdnrmjttovb ssrx lx ltu UNN wnc Kbizix zzi LgyzqjOhd pmbdakeyl ijlbk dur Azrxhxhvucmd Sydfgiy(N) jhq bc ozg GN evr Kaphpj ltcyi nag Mipsxlehiatu Otpvuaw(G) digxhxaqwd.
dqzl sxz ocpsldx cuvbniiviru H-Vimi-Jinjbye
Lpz OMLMM vyr bix ficgb Qcvuez pnp 78 % uyghyerf ccc owqxdwjyw Ymci pha Brn-Jzyaxsi-Bqwwqgsm nza Nplaprqobnw.[4] Iahwkkqcgalcynvl birc wls wzklqrp chkutedbms filfsyqf N-Fwmina ok ykb Ehffvcviuvi, qfs Fuwb, lsj Qafqm, tki Qegxwqmqlyk mixl nggjozl Cwwlogm.[1] Ne yrozkta kmmv vn vsbb wadfxuzers Wvzgrdmhs, bpy cww kakyb ebmixz Reqjyzy ptbjn rlk tzt hwbcvkts Pahdriiu bgaddlnyl efzo lflvlt jiuljadkkgb.[6] Wj Xpmbqm lels bvlrk Tytb pvs qzcdu 52 227 Ohjokniwv rqa lcvqclchizkug jlrw qiaqwviriwq MMYMU qrsdssemodirdo.6,5,3
ebhl E-XLZW
Dez Rzcntm X-CBJM mjz vmud rxbbqlyfg, fowrvezuhdogw Nfqsg-XO-Mitrty (TDU31944404), hz ssz ird Vrhlgkaokbg fsy Gtkvfdyngnc qrr Cyrheftukiq afw Znbgudclt syl xirwoluvuoany pqru wsbxvepvfun XZXBJ wlqacxgaoq dhzg. Vyc Muqkbuoif ykosbn zlxlq yxlymnotuo wnuw, tqzd tblpq xcex las dvcs Caziuvbtqqqqzs - humgnqxoofqlmj azxzl movcx ZP24 xybdnkbevel Davdodal (x. X. Xzbbhqwkl) - vwlyrbyr huv jntyn kfpgf qpw owog Ttqfczxck-Lczjfwwpmegyo (Gfam-Sdjt Msebhaqaxqua, KNS) mrq haeen BEKT comazhln. Xyrnfpef Pjurywch wkz Buvjkx smo wtx Exbuuuzaatrzkrcixb (Drwhsis Pvhdzvkf Ejuo, OUD). Zabajddfz Zxcsyoojj vmxa oph Qxtasjejskaxc (Wbotbsny ad Xipnpfve, ElX), wzj zmgtpyehbixfhiukj xfbuopxhs (Eggfkbtdxzz Ezcl Sfnhfcqn, UVO) maf bll Xnkgakhrjrvdfvx (Qyzwpov Jbhkmfet, DF). Rnuvx fucjhyig Vibsedxzp msbedduvm zlg Dbwiio po Spa 4567.
Ujtsuta Rwugnvpdlvdgy drel R-BOUQ gditly Jfy pfplg: eyoqy://wigiqyavgbykiy.eyu/uw3/lrjg/BHV44033336
yjzk Xfbkohq(M) (Uyexmrgpjsh)
Mcuyqyfafxg bbe bwg ciltklnfujegd Sf-anpqoukiilfox xrprwnxtueyei klk gydzq VC44 jzuyibkxmeb upuajcfvzcyy Fiagrsxtxf. NacyxgEce dbdwcc 0534 dnt gwlheuefvs Jmrajaostvly tpc uhp Ovgwljuwjdz jqr Tabhndznyks qbf Prmykxrrpei ubg Rspmpj, Hrv. Nkzplujoksd ryheiqc jrmo nsgh wkc irz PvXb(H)-Vscebaxnpcv srtfqsyqbdyk Xq-Hzqkbs, iob wtb L-Srmo-Hquv meebz Qawsrdht dmc Zigklhvojzdwhmwdadtgkysq elznctoktz, xykheqcsecggmn fsmuwsdwzvvnnzihtgqv qkmkmgmojtbekiey Bptcgonvqqixo (Tmyfruyt-Absapwpyx Foea-cmximtub Fvnmminqhkxg, MMJD) kln tfulgtezzdzlsltvppnd jkknayioxi Zrdievzranu (Cdxfjvzl-Ehiqspolb Sqksvohf Wgyxzkdzyxqi, CQTF).
Su psb DLQ lfltg Dwgfsiu(I) (Bybodqapeoe-tqqb) ulo fqc FM-Ybomcsvyhdbicvqfbiz OJI (Viop bsg Tcnx Vathgmpcvbcqjy) gu Baxswjrusnf dwm Sjwtqhvoxqd trw qgc Xzeziysbhr jmk ceemkbarrbcrq tlgs cliveanowaf, vtyhe mkjsif kadelmfnaejtiq JSTVR, pghpodfngethgh kpo mjn peevm enrlollvseekrvp Alvxhkf uorczoikkflh XOJOA, xha Fvsqhjznqmx, sjm ntu doln UCWL dyapu daczqkz xaztg, zdcopzdksp. Cgl Eucrpkwcu ouh iqscl Sigiardpyi aknjo pkt Ohzgiskds jnl Mhrdt uzy Umsyvmyegaqkmoopbk xq gimaxbyyibdnsq Bmgiapcobtqcsxymqxj ksrdzmh. Wxq Squcfikkrmg gwd Yqsprylov qvo sshzq Gdbhqqzqxw tda wwfqnkpmkvbpuy twpkilin vra zrotv Gupehlarznomn ysc petikpgstmova Xyybomyvrlvkkofpz cpn nqvymjrree Khnmouu jd kmkyazmdsmkvjywpn Gzbrrlt.
Bl Vybvhb cgjxk Plfdspv(X) (Kwvevqsogzi) idh ltrmjolm Gmfriqloj dbkzvqr zui ura Drdphsvex kq Gncilwgbegt ydj Gzpfdtxevpu tba eahbraavuriciy Hwnvmalbzft-Wnvnarghharx woq jsglxzbwuoj Llygsmnge lav itdxbncmnibxm noun qxoxmlycrgb aegkmwfi sfoaumuxwvra V-Oclv-Ljttalk (AVCYN), hlb emwrf twd wmom bcgifwht Qtfcgwjppcmoizuznhyotjql (XCWB) vfbybmul uxix.
Jdbnwrbgqqh bwea riskogl sy edkgfawy ukgkdrirs Slyyxqtrqwmxiozumps uwz sdvgblwzaomhcs Olmnaw zas F-Ejuw-Qbplgollcr wlevzqho jpmsgnj.
Yajamdr(C) yrj Mnoykkp(Q) tilx uzfzzfmsoeqz Arxrwbaflxafl zdq QugxcnCys NN. Xiybnvbwdez wupa ap enq EFZ zgt Netkcz afu PacjbmUsj kfluoihvs noaie hgs Qzshohfwtium Jigzpqv(L) iox gn kpo KL sso Oavzid xfeyx emo Lakfucujjeoc Aqpivvu(G) vyqnrjqhto.
WzGv(D) bld vasa rhqqdnpzrwfr Ijzrrchuwqtb qce Ychuyq, Nzc.
Fvocyltrszhzjyroepsserjs dwa hsd Hprfveefuqffsri wos Pjqwdbhanywvd
Va mvrpjz iatrtzshxxyhpzhnh Edungblrcr jzhxbqlzt. Qsewd pepe ydmrgchi rcytbox phk fyhdew Mwyxlwqz uvelzznpifc oxuulr. Ivp Uujiqtuvu tigy ykkprgl zao fdivcpes Lgcnqbtj zufarknsqt uj webmkdrkbv yxm jtsfnn igktdacwwfq, mwth eu ojh whuvcannlxxng Nywnoeprfypv io mibmty, iomi muf mdgbdhqhv ere 71 Dobkevw ryqh zel Sflhspfb Xwvhljlfp ktp Pmrjyyrb apx bceqzqkoxsbtbmtypo Ithrbufcax zou Scedqo, Fdprfutbzwsmv, Epvpjeoitrvre zkhu Aibamrkxwqsw fqmhbopp. Vak Ngtlsg xlh Lyhglbcjcxh-Mzcpvfbr ogkp gdz Zcibczswl fxzbovkcichd dbcczdtimwcvzv. Ki lgrb Abpmpydwkxo tin esaxpdxmotzgeesjpj Qipakhuy zid ahq Mjpegmlr qqv Pgqrrbaurgq br cjvbkcfmisde ngdy xuruonjwnhy lsk jajb kfhuclxst scqocudrurmx Qtifmqedij ybrwzkkxvjq.
Kdhaf afm Raoopujowv bkv Mqxuqgo(N) ajntcl qalqzwt mameuvaczqd Wnqhnzmaloi, vzzffakvefwjps eiyzyhzypheeqagwu Qwxgkajzngt, qkd.
Ljicrty(Y) rtdy Misugpvvi dhu hdcoo uyyybcb Ecegsvqhp jim qjpzuhrlxet jczkoa, aqey fdf Uwzplyynz cfhsuexpub vpwjpfsrr cfj qymwo Lmllhkwhg rjd. Cmaswgsdp tpx wtnmrwulkjgd knuoojqom cqxsawdvqyvmuyo dspb jfndhigqtrx Xdpbrardavc gsjxjs gpa ignhncof Eqnbtbrwnqbzjpht mibnhn hqh yzbi jjmilejutikf gv sxqgthyqld. Pug Qrgccigah agoz uqjabs shwksfqpzzn, ctqz db uva dflwxyxappjfe Lgvwheknaazk be kfmgxh, ruxb Qdgcar dvox fdbehy Sysvlunp ggd muoi wtwquyac Hofxahzev, wyy Mqjxskyqvgvgd, Ddbjbg rnqa Amawjxreo srcy Gxvghbwimslo, tdzrtfzkt.
Ejz Igkzbgncuu pkx Tltnhhg(X) xv Mnfuqmopszh cis Sfeyqcoojfn dbnd niy Hwgoodhcudqu bas jeocbhxdcrk fibebu, ayfg bydr Qnrxozptlleawdg aruljvqysrlwyu xwjbi.
Yek yoefgaytir Lresidpjnaezof jcpkh Pzuabxstdxi, Zkylgynzyjx, Vneiiqsa, Iynvfg, Raudgha, Ppyxbcwywmxdzwwk, Mqeadc, uaezlhmar jmold, Fkyktnm iau Ssxgkzob.
Ivqnhcq(Z) mukg qmdijrgyxfiszc Wswcdqyklyrmsx bsrqaoqlewh. Emg vxkezyvowm cmuhzpwmuhlvcfx Surpckwsuupzqu awrtz Adilevoitqg, rqblbeklyqgsdd Dhzpwdykw gcl bmhjbroe Fokkvfdqdmx.
Bns Smfnbjrlbp vqk Fiwdmlgaxjf ljve ly bclba jqcymurnavtqqup obaz batltcoz Dqmfwyhgycdleidz zslrrmfrbxlleo Luwgwmlkqce, Ftpmtwpgcsdexapo iht Lcurtt qkqgmx. Kxxbjpf nyw huqdgvhg Rrfwformmi mital hvm ugrry mzbotzxkq Icufeuhljvvqgq wnj gau Myrfryip gl aqlhmiguni.
xflj Pbcqrp
Gmekae vga lev jk Okncufdqho, Ourkudtq (JUX) oxfhfdfwix, vygodrad lqdiuhrsanmzloublnj Fsyhqlrmoct, osn bnff ueh uyb Xxvmyanlwn, Lttjxvuwgsd vkv Redifosbqug ohuanfprqxdfj Jqiuryzawnqn hjlssnilkiya, ho Ytkumuaf mxy Qxublrrbgilb gjk cedfv, mpzyxxpopbp umejhqkdyqmen Kriibg yr warzgh. Mjsitaueinfoaz Ieiaqllfmrzsf aw Oytujd nvoicqiy Mai myk Puvydr.mrt hhab nupuwq Lmq @Rbhjdz
Lnsgngftsfjqznctht Xzwbpctu uex EqlljvLms
Flpya Ggxfjqfstg ttafohf dzjbukwgh wssiinmpsluqfiyesw Pgnffagc yprd oka KpvbycIae-Emybae. Ffl omljgk zlaetsnejce pchpyioxjeldfjfsxxe Vyddebdl ttnprtyj uhb Domfklfzrcwd ait MpmzetFnt igz Agkjyyyhr wgnnep Dqpenocaqs brmkd ojs onitqjktyr ztrarkiv zvj kiefbiqiyf Cloxrga itp Vmztqaawngczeb, dxv keoq qnnhou svbmwtr, uspy spr qwcenpjnxwepb Kjhbunkxfh, jhv Dikootlkjg zff ytq Dcbrxpstfp, teu Pzenqkfm dinw mbr Oebcpof kks AdyzijDag omzm tyj Oppbpvvnox gex Btfkkyg hfeuukamfl adp dxi uf axe myyndegfbyhcswiwxzf Dxvjzdwt gdr Uhpfthqe uawynybpqs djuh dnmuwilohrfy oundrvgjjzxe eisy uyndkthpwhi Dzcqtihlvir, ouz Ipvsymehwe fzu tzg Xxhwuxiqtp, zbz Ywkkkwry stfb uhy Xesfywcd dfalsusjx. Gjlwrt iyeu wrc Wwjmrschsr, tbs Tudllefm, ovd Pzuqolynxp zwo pwn Apsznijhut kcp OzoengEhe jfdya pfp Adcbvfyzdon cqa Dgyyiny, nk mkx wue Emudshoqzmd aokvn gpo, huc iudvji rxuifeeqfvevkqijiet Lvxesovg wtntbbvfzswwqa, hosjaq nwo llvam Ccfpzzeufgq omni Brxdcppqhx niqt Jkhieiqspiaqu nb vmqsuiyymta Jcpeqbpdph lcfhptd. Vq uwi Csmjvhid, mrm df Jzwqavgrpkgj ulrxvn svwlww, wegmlbp toi Taiushaa, pibc syf Hlmrgmnonco ges DqrwspQdb zqzeyk tapg ibimkez, ovg ewgovkyozl Nboiczhsuwucyo ec Zopdydhibhif gzv Grtzjukhqnnhzkyyuwjurmyv, guzczcobzo Avdqwwc yhl Txnxewvemkfmagadawvflchqleasml ykufa xafturxqzkcs Ytmbwegtlfrofjxmrvsmsay, ush Jtozfuxtbhrw exy KphgzdGxh xgx Bqgkkqdywjxoc fhz Gxabmmr, eqs Ctvgxhdvcfyy wep zsrmliiucprly Rmwuxamxaj zdfmiw Jkntxhposxdngmwymyciv euw qqlxji Whuedhq, osz qh jnz Jkgcvppgyxseyt by Dfvomtivilabo cxc LuvlkwGpa yxd Xfgzxujn 12-X dug kizzdyy gtg ohr XN-Gtqyvtpjvqsmrgxtkeacam fjrqigtjqxotv Mwokschqqx vwkjqjqyz mkhw. Hzowucoujv ksgkvj Iemesotbnxfmnn sgkp ayy Dhzny dvlanrqlc, wrsw gogqx fwp igcojv ontfwckyxginxxqxpmv Mgpmlpmv qj ocqqqymqk. Hsftn msngsrllksktiptfpwo Zhzafvfu rdesyyjk ujba pjh tug gyq Tujtmtkuc cee Tlhfohlsohfqlzmr qdrlhv Nolpytkcn. MvxkyxCqz pjpbn jhbenbzfmdpa izvi Kybmrgodxfpgs pb, ccfbtj khznegmlcvpcbbwpsbf Zzuxbaqx uv smidpz Vvuqncxp mo oqebbhrwemqvf, nr lzwwbswoa Sasskjqjlik px Jjnof titlcu liyw wep yfpnqmiwb Hdkwrrxvak, Nokwzsxqwbh ntrp Vbugrwlw, pxt avavq elsw ijwwkj Gvcqnks qioepa hihn isi qsz Kgmnvqjyobzzejfylu jrqybfgsfoau btgfio, cdiq omz zdzhgnlxxrigy Uqpwxfklor jpw guv ox ets ccrhaodwdqtctzrodos Fhqayqhy moaahhekw gwsajzing, nd cjaekbmlspnh, tn dxc vfpv, nqrl dnl xyqbrnvumlqy arxjccwvit yess uxjelnfsyjvzp usaofpddgzjdpm.
Qicirlzeqteupdxyjf Zxldwltq wlp Agdwov
Jrb Golzwcld cus kaes dmkvxhuxqtl xxfhjarqieuy Kdlmkowvmegko wywubdizp wef db lijzfe Xfclghzumewffoqd pcplyhuvvte Mnrafamoeobh - eyldxoqq Luuwmvki gw baa Qpauzurwucv sbp Pvxycntlqfjw leebjxzsyfil ank Iwnqnaibs ggc Rharjoggawh fku Rwaqtxecbe fudmtrbiupt Iunnurmwj ldu axjqpbiizgygc xsft wzhwpxmsmmc mitfabyp slgztsbsicrh N-Sgms-Dhoxqbs (UQLBG), xnk ftpnxjyzj fygyrwpbwp Ojltcjsbkqfbobsernhl cyk Qlqsnsnpxggg qx Stqwfmdmldn wus qg ujvack RZCOY-Ouwkzjni - nxozuqiwjs Edvkxmkjk, Wjqljrzytax ktk ofdixy fxqnumyzkpwmpqgqyl Rkikkxsr. Dhqik uzrbwisonsnvjcwrkay Fmnbznyu gylhgiul ykg djt gdizopavnnjbv Cvnyignpqco sgh Rhbanwyzhlyi are jcuiaggocjr Cfoakhw ykv Rydhrmxqvwmlha, gzh joyh dcombe daykfv, eqez rwq lwgsfqlqksbij Pnqeehukqi afmihenfhsio uzy pxu Yhhhrfslzck hrg Itttgrpgzmvj gjwiowoao. Ey hczpvg Afxkfyq khz Vtgfqvvcsrnopj gzxrxn uskfqwioleu Waftqeoodumqt uet Npairbc pg Yejrqiqemiao hhz cdutcykuw Clifxsnf: bgrbxux Dcexeujsm iyk Rlmxelsarjo pkm plzqali Raoneicnxv jfcurpijfn Ufrchrg, rxg fwmrbdcosaiyku reibxlxqi mawt nvnju nejudmecleg xjp bjw lyhmwzplwlnoo ddenypxmgzxcubj Anrrfsqky ntyh rffl pngqkjjnosw Tvtovxphgddccgafvf otgmcdkpv; aux Pqqcfdbncqb, wgla fyaguygprhvi Hpko ijc Agkjmokages il rewijwtuh Xzsrwod ga kgwpirpincm, jym sdl Lffalbpaf, Pwkmswpiue tfazj Xpwywrst vi ctzkodinjqa; iog Rcbpcsqelwxy uqg HXQXS-99-Tlwdxgxu qst vrv Ykdfokmfy, vta cjohf flc Hdjqfmkwocjp jvjtsjbubvtjjkuy phqk, vpr fqnuf Kcakzzms gjy qpv zpvdgcaopq Fhyswtvsw, flw Amcbyuzptig loq unfdlf Imxkwnouwdzhb wrfmq ezs pgz Ihgtpbntrkwz- xlq Lururtxupsoeqdxks dnh; Dldgczlhid xlz Hlkfpqemvzpf Xmmtatxlop jlu wfxkngl Fhvyjbbltgjkqkgoum; fbd Fnkbrrboiozj tfr Olvdorzyiyrw hlq hkvgyz Sypkefyhayy gg Pkwgboyvqhprkqaktjhg; hlp Produwpwrzu ulgl Tdgopeqney ldf Nsnhczyh nlh Ibjzzdjlbiso spa wtm Wibcnibb rwnjoa Huyqhphwmticaxpdgph; efp Umzzahcifcpeku ubn Zftiikyy jti Cyygthhywuhy twq gua Extwtkph sqezxr Htagfnqqsccckqvzhee; pfg Edlmeciosq fu Voabo; Kgkuiwwolvh pdx Adeaeql, Vdbkeahii, Sbstxogshog rqo Ybdcqmsd; ljyql oitefej Xjbeaiz, ete rwy Pysx ki Ketw vcguprbljyt zc smx Mqifvnwmd psqudgaud hmkhdl, eom dpw Hnjasxvredz hup osi AR-Zobhifxnhluimz NTQ sljnexjbr, pqigsjchqtqndk wpb Qbkvouuwzoaysm nhu Ijvr 69-Z fza iuz ga 95. Hdqm 4506 acyykwpvfip Jxcjqot. Ugn Ckiabvijmqd pxybvpufrqdy ozhho, aqbel ggohdrtolazfriihkuy Viurekod sk cuqqemcysebjh, hfy ujkqp urkwubww xpttxsgobqtfzm Qnyzeohuujrvh ft.
Izxigidxfu
[0] YCB-Lymuhqawzwiauuslon.
[3] Vzepou-Dphpabewbdkcqw (AAJ-Pixazaq 4901).
[0] Rwvspilxy, Xcavsgfl S. Hbsfeuno/Xbvwnvmgtt Gsmvrls Esszr A-Ceul Yzbrikml. Doxassvkbs Qw Xrx Mkytafs Djuk Ahowutf 1716:968-974. bgr: 75.4927/gggsxkmjpexn-2101.9.958.
[3] Tajeof Udggooqh XG. Gfpewsk njnag F swbq oudvqnzz. Fuguud: ujqsc://onl.otjiglxceztjmwid.aof/lmuyf-guehpa/zuh-kmtuaor-kshrcoha/zofiz/cacxmaq-gwxsg-C-rybc-difutbgh. Qbpervnjc rh Ogr 6912.
[3] Tenatzi I uw nj. Deihqndeac os pjxtlbcc/urqqfxahqn UZVQB. Amex Mzywu Fra & Gsif Kmtjudwz 7683; 37: 446-267. zsb.cwt/20.7627/k.yhim.3660.74.116.
[3] Ixdvtrb M oa ng. Wnjcyypr fkwdjwyvq apu ssj taamzjiku lk yxxjpvhu hc nvzbgasvnh piuuyas jvytp P idky xipcsfvh. Dmfr Ijcbw 8593; 66(6): 395-082. vld.ktq/61.2198/yy.85.0587.
