Viele Anwendungen – ob in der Medizin, der Biotechnologie oder in der Landwirtschaft – erfordern die gezielte Abtötung unerwünschter Zellen. Denn diese Zellen können beispielsweise die Gesundheit gefährden, die Produktivität beeinträchtigen oder gewünschte biologische Prozesse stören. Die Herausforderung besteht jedoch darin, dies zu erreichen, ohne dabei andere Zellen zu beeinträchtigen. Das Helmholtz-Institut für RNA-basierte Infektionsforschung (HIRI) in Würzburg, Akribion Therapeutics in Zwingenberg sowie die University of Utah und die Utah State University in den USA haben nun gemeinsam ein CRISPR-basiertes Werkzeug entwickelt. Dieses kann anhand eines erfassten Transkripts bestimmte Zellen gezielt abtöten, wodurch sich zahlreiche Einsatzmöglichkeiten eröffnen. Die Ergebnisse sind
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