Orano Med extends its production capacity in France and the USA

(PresseBox) ( Paris, )
Today Orano Med announced that it would be investing 15 million euros in France and the United States to accelerate the development of therapeutic solutions using the radioactive properties of lead-212 (212Pb) in the fight against cancer. These investments will allow the expansion of the technical production capacities of the two main Orano Med sites in response to needs related to preclinincal and clinical development.

Lead-212 is a rare isotope produced by Orano Med that is used for a series of treatments known as "targeted alpha therapy", a promising approach to fighting cancers with limited therapeutic options. This approach uses the properties of alphaemitters such as lead-212 to specifically target and destroy the cancer cells, while limiting the impact on healthy cells.

In practice, these investments will double the laboratory space available at the Maurice Tubiana Laboratory in Bessines-sur-Gartempe (France) in order to increase its lead-212 production capacities. They will also finance the installation of a cleanroom, allowing the facility to achieve the status of "pharmaceutical establishment" as recognized by the French National Agency for the Safety of Medicines and Health Products (ANSM), a necessary step before clinical doses can be sent for therapeutic trials in Europe.

In the United States, the capacities of the Domestic Distribution & Purification Unit (DDPU), located near Dallas, Texas, will be extended to allow several clinical trials to be performed in parallel. New research and development laboratories and the purchase of special equipment for the development and synthesis of new molecules will also accelerate Orano Med’s preclinical research into peptides1 radiolabeled with lead-212.

"We have reached a point where we are sufficiently confident in the potential of our lead-212 therapies to make these investments, which are vital to our development," explained Julien Dodet, the CEO of Orano Med, at the International Symposium on Targeted Alpha Therapy, which took place this week in Ottawa. "They will enable us to guarantee our supply of lead-212, and produce and ship clinical doses for forthcoming trials, as well as strengthen our potential to develop new molecules to enrich our portfolio of new therapies. The investment program will run until mid-2020."

[1] Peptides are chemical entities made up of amino acids, and constitute one of the main sources of drugs on the current market. They may be natural or produced through chemical synthesis, and are able to bind to a target molecule (such as receptors specific to certain cancers, for example).

About Orano
Orano transforms nuclear materials so that they can be used to support the development of society, first and foremost in the field of energy.

The group offers products and services with high added value throughout the entire nuclear fuel cycle, from raw materials to waste treatment. Its activities, from mining to dismantling, as well as in conversion, enrichment, recycling, logistics and engineering, contribute to the production of low-carbon electricity.

Orano and its 16,000 employees bring to bear their expertise and their mastery of cutting-edge technology, as well as their permanent search for innovation and unwavering dedication to safety, to serve their customers in France and abroad. Orano, giving nuclear energy its full value.

About Orano Med
Orano Med is a company that combines biotechnologies and nuclear technology to develop new therapies in the fight against cancer. Orano Med has developed a unique process to produce lead-212 (212Pb), a rare metal used in targeted alpha therapy, an innovative and promising approach in nuclear medicine that makes it possible to target and destroy cancer cells while limiting the impact on surrounding healthy cells. With its partners, Orano Med continues to develop effective therapies that respond to patients' needs.

More information on www.oranomed.com, @OranoMed

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