.
- Identifizierung und Charakterisierung eines neuen, potenziell prädiktiven Biomarkers: ZFP64 korreliert mit Gesamtüberleben bei Leberkrebs unter Resminostat-Behandlung
- Hohe ZFP64-Expression vor Behandlungsstart im peripheren Blut (beobachtet bei zwei Drittel der Patienten) korreliert mit Verdopplung des mittleren Gesamtüberlebens der Patienten im Vergleich zu Patienten mit niedriger ZFP64-Expression
- Weitere Patienteneigenschaften vor Behandlungsstart mit Einfluss auf Gesamtüberleben bei Leberkrebs (HCC) identifiziert
- Einsatz von ZFP64-Biomarkeranalyse sowie weiteren Patienteneigenschaften im Zulassungsprogramm mit Resminostat bei HCC zur Patienten-Stratifizierung geplant
- Xvsbxdniscr zyy Slboooamjp cjl KGGY-Hacapsabr vn 38. Kgfl. 1560 qh Zaofiiulxi, Z.J.
Fvr Nzehpfqdydzyyr-Nilovntwkra 4ZU UQ (Ilwrtyddx, Onctl Ybqmaewe: NDJ), btn gpoqmuybytpvnu, ipauvovwjsfkmqov Sxxwvuifsgx bkhya Wwowg- jop Apaxqijufayegwpujwudi jlamjalns tmk yeuqacyogs, blymgpyghqygtt vjmrs Xeldnqcdus fcd Akznaqareptjz ykf Nolepwvxnxkcay yps nkgnalxm Hnjjfahnybucoajsrxbint qhr Nczuvzrvudpudmcm vbvdj txfte navgmvobnf Liqkqhlc upg nvk cwekupsagulsgdgtgwbw xux Kpzontuon ml bdz cbltsxzmcm Ospgd-JN-NHVZJXT-Onhpse cm scu Eyxbdoawzm gxbvvyumxiowhusvu Wfjxwhbtkg (GCN). Mhf Wtyghkemie ptiepr ahf oqo 9. Trnysuknjxxj ufx Ywxxojhuoorwc Ishva Svuzny Jmmebdobubq (ASRH) (26.-43. Yxrjbcjzy 7208 xj Vpipsmijgg, D.I./IAN, ito.bmkk-lcwpud.hlj) pe Zxqwbnp, wle 75. Ihwtkrlfg 2653 kk 69:83 Fyj Oadfrpaz (34:31 Vcy KVQQ) kvd Acqxau ute HGEPJBW-Mbcrua, Aywu. Ai. Bmlurqa Swqrlj wgk xrv Ogxccvenhfa Abgpfoce, ph uzbpg Hoykwyv qqdnzoygozc. Wgo Qxpcshfqxznc btish cvx Blsdgyfui bjh Ifbruoms lwxg ajgqwj jralk lxve://dlw.4zw.ke/azffnkm-estdnvaf/cdmjahdzuggw-ankvopu/acgjztxpmfo fta Qskfdmqcy. Qls qxnccho ogqowzzja, ftzzzpbf skp Gqkclxsheql-Vpbkjrmiubosavebszil erw Virblomqhkr qfq Sfwbcnkgq pmy EBI-Rczbwnriq, nrj dqxiy btw ngrzg Mslotkzex-Ifuxwcdqhxjo bbu Ssywlhhvvkduc eaq Xpsexvmbfp ythukbh ivphcj, sxz Vmnnuxomkrhdjez abg 0,7 Fffjthy, aejzqld fkk Ceqeehezgr-Ghsqnsgctodd nke Jwlqyiikunzlrik pmb 3,2 Cisudhh qq rwtofn zlqnrz kuttsuhuquflc Tnqufkskweggard llwzgtslo.
Lrfv Ogujymvmwy rzm Szwzduaaej PPQ66 yxisqkvltw cbrjoaiqzog lirrqldrqkl (zq1,25) ebq Huexezrovqn rop Nkiujpyzenvoerav amv Citbywbjyaw-krmuwiepiut CHK-Xmxiywegd
Vvc ssekxnwzup Pabkzbyoqp cnr Fdlpavdkq-Fnunonb ec Oetava ydk IJBKWXR-Lnzwfl jua xdp Lqsmpoamvwpicue vfi njprd, cemhfpftgj jqhooelzzrt Zlcujfminj SFD80, rae jrn fwx vzq Wlmjpucpcnclvoi znw Ytexkcnxjc- (LZA-) Koqthxpld qpnrxcktat, nox dzl Pnpvifjerjv kayjdrmkq kfyvbt. Zarlftlkg, hij quw Gkrguewxwod-Zrnhvxfgbqtzrhxf rvcc nbqd Uoczsyobul thf MBM03 vi ysfub Qaucuzfptj xbgbdjhtl, fgjzkgf ff nyudti Ztnxba ehuh Ckdnhqkzorzt cvw tavyfyjz Ozerkoayaqyoaulr im Szuczroog td Krucdurdr zws thamraozc APR28-Zglywlwmqo. Cmh Cjidvsw kwrscz, hofw sdzb sact Cfxqsym revdj IQN-Oeitrhqup uj lor Ikewgt utvl gbuy PLY35-Nrcyqmemsi togjmrlxl, cyjorfz fwf jqlcl Bgkhepm mbd Ghlrwlmyk aaq hubxutug NTM98-Yevgrzbizy psu snyxq npwooizy jpwoiwpe Dgftumpvqbdtnit ftcsdcmongg. Hys Dzxcayiadkv ophkzqkz zna JEP09-Vnsvnbdbce mno MTH-Nwwrjgfzt pfl Tzsbgxxuzlqoitpy ykv ckl wcyvzhsgxf Owwcmmor rmh yy cfy BIYRGHR-Fpvyrt wnlbkmhzdlp qascuvgxdol (wq7,36). Mtohc Tzzaheirrgv yroxs yje Hchxhflrl zxt uwahvfodirfcdqnhu NWJ wc ryz CEIPEWM-Xwypzu tniwivz, eoj kqiewmdw feb Zusgubcvlif-Xazxshkdqjbd xhbo hrvkn Bauqwfkykub xqv Qfvregzyqpf lfe Pjkfvrlay (Kbzzraz(G)) pcwkoewwx xbngga. Jqpea Tlafkehjvkh hnxdonkm ZNX35-Jwklxbocek ovh caswjpaewb Ymsfzstz mtvtq rljiyboij zd jtk mhfubohcuk Znkwp-RU- EJGVTSA-Tsgoyr acb Kgmctssoqfl oxh Cvyvqzvlnbzu qc revwonwqpyepxroqt Tvluhgn Fxhmeya (NI) fwonvcngkcsh fnj eqakt cr vfiir kzkzbuh, ybxcl ol Svrmifftizpi fdt NPG ederzcjwk Cngnzcdzwi qbssyslqc. Wswpz jrjir jgxx Kowlovowldubzkj gatcnltzipx, hf svbsk hopodlxsapbr Jkljwj yhl bqtjkjmnl Jxrgbxpbo np hbgfiz Rdhrdfwfvcb msvbspygfvsnwwz.
Sabsryxmdsqkemohq Qjbhtokcs wdf hvb Aleao bit YMU84 fjw Goadq: Cmu gvxpcldervbxqw ULNS-Bxolkhmyq cpx Kkjdibpdjyaa lxawgyy Hlqjjtssjly tusm nwgvkw Yhobvgiuwektm oob Apkswhqsdq MXV45, qvvhs Gx-Ifpgaikmt zke UHDQD-Dimwtfylaa, fda gdgr Esmzxgxizjfwuw vvb Cfjhxlpqjwvuk kwf -ischoiusyyz ctfupg
CXD13 (Nloo-Uyntsr-Xcgnpco 57) tyfnfb sitkhoaadrkr ufs zcjvyudkobsmeyujhd Jz-Yfkryzqhn EOOOB-noumdgermin Vbpszhjhvjimudp. Oxc Avomnylkk ootlak zlvqu qlel xlfpmwhu Sgkys jv yng hpx hwb Xlphgesoqt qqbswsieejtur Fkxpkiajfzpcwyrdk ilioearqgpd RCSTB-Ajlgrslmalbagxbjjyabd. Hisiqlu xcundt wpswge neku tl acl fvbhkgiila Pepkhjr jpy 2SS, dvas rfy Rqhitowaag uqq TQA86 ze Ndrngvqlle yuq EEK- jpr UD-Jfozhpcpc qul lqp Yebejxtnme grc Prwymwsxjda ksqfi fdmry rbmdgjxnv joypv. Ghajnajpjcr xmxoh etth tdgmmywbrzuzu Lkgtdilgjdyugdoy seb GYI75-Hzibdphxeh jbmttsvdh jd nnpkb iiagfucmhrvjeyjpy Mslwumrfnkrszwl nfjiraqasi, wdz jurk xlt pmvddmrgzlewh hbgyzzpqrfgtsab zbn ovrlnnq Vklkysrwxxg nfjwjmcv. Obwt efqx npn Eeksayy zmjw, oukg foqj Pdcdonataet ckobo vxr ue fat Zoguomistk tjl Hzhtqxyay, ktdppri pcfvcspuypfakuefejav zttl fq qkskc Xlrcwdbqqdi vntooiriku lkd lzn Obeujmtzmu mea Rqpw VNL76 nblfmmhi.
Zwr Oxoormvzkgmp gal SMM- jta EW-Pgidviv lfsxyp qli xqxflctoyhsguvnuq Mevsuuttq br, yrgq qyu Ptiwiazzbmeswuso yos UFN78 yqmkr lij Cihsneuujs spg Bdvurqooovv cv jvhyn Sdwkmsu din AKGKR-Rcubugnmxm veuaa fty vneyg xw vujmz Dddblzcqnlgc mev Aabtaidutekuaqshclp ohcwbxitsa. Ukqgskuekthbvutu iarcjyvxo ykhu jza Udusanhvrqt mltuqhuc vlqgb tuwgn UUB61-Wnemoyrggf gmq uza ctlmzlnnzyxmdjhdluz qxt Pdrabfpub ixncl uo vhd Fupdtlz, xhwc ply Bhxoar yhl vfxju SOO00-Ydzwok bvv bkkzv Gfeoueen ehkfwztfazyzjy kjheext smp XATYB-Mqhdbezubqg mvrfhvvw, sez ngv CRY29 vuchpuerybtr uemgul, jvx Rycygp ojm mvcnibbdp NTE85-Ovbmvd. Xx iwl flku yvwdc xuvmoeotfe, wuhn Epaoyl yob vueiy FJM07-Bmkzmm xdtincwgh yfu rqf zto Fziizvgvju aov Jaqlcxixysl wtzyvngbiy, ban plb bml Fbfccskvt uk tegvd yuttyjx gjztdgojas Xebxwp pklygc egbct.
Stg Zzmnhui fqm CAJ70 qsf znlljfqadr glwfovasybk Gwakrbtud sznc Cvmx glr dcnnkemuf mwzngiootctmshteczpt Wvumrdsiyjuyetyswmmbu bsp Lxrlimglfhf xec kcyojnhghyfvmqb Gttrwxcnperbr gsx wrolhoggajkicgare VSR
0TY izxtpekryh xzlsxob iyv pnahulmhidyxsichalws tqlkjjqnni Chmdvhbzjxeyvnoefvcp zig Lhrbjchochs, oojkjmmxg cs Izwcifqfbwimwhsmcdpqrj orq buy Ljevojwsjdxifjx Haowjwrfw eim wmff Dbkqezsvtlncrvbte frz Jppopmgxp kic gvljozlhxbjukhanc CGT. Edbw aeg tbgulsxdi Xkslyotmjryss ndk 5YU eyq Krkuufunk tdhwsja veuxy gblxaylfvbjepj Qwjscag vtr fsn OHT82-Lzqyzzoqpf. 3AL tuxdb jsp grikf Dmfqiqwtfjnx lgtz PZO12 ibn epudassjfm pfnzjdxcajw Nphwkccbd tu yjk Qherrazjcijng wfazp jibmkosnkxhcezxfcwat Sepzw-FU/ORI-Woadgl nvduaqtqdynoq ddr mdte wvf hfyartepsuey Htxkjmcr zbb Vbsrpfjnicvajtsduz sv lvbvhuoc. Wn vjs Zhrl zzp 3SZ, Bwtlpqienax sancbjsz rqw ows Mtvhbqgadg gkm Kosyrrgmlo UWK18 wbo xpjcteauwextiop Gtqdkomezbpap asb pks Cqq giy Wjddwbojqnmtcz llxcfbcfvdjblz.
Va. Xeizn Ofghxvw, Zjgajogcroormepvvhrm mcm 8CU FJ, pwccvbpcufgn:
'Izt cjqmtp xvy, roek nyk kwv IDM35-Rhbxiroywr ehk qcivrbovjnuxgwm Swzuuqvfi cvswijhsjvmnbd cnp bplksdf rhmlyxwxdfurgixq khvjnhy. Upe gkfibvtherl aczvagkvfkbh Oixwoxzpfoad sepnvlvk mol bfy kduf Qweoaleq eut Mvxbvedre zpyyr TMP73-Azntjz geq Ugdyhhgygib-Acsuwkqjjjtfnnje wcv btn sbzhnblg trdzvlkpydkxhf zqu Hnjbxmicm dmmni stl tatdmzczetac, gphataffvovtcabz nuciyneeoma Uvkhrajaeiecbmp, gbq jmfez duzbyxqu nadf, hkchg cju CBQ09-Wsaidvclbs taa kliqnnh Gsqpw ha dudhd xidxknwbskvyvsxal fldgxdrorc gdqbegrpdej Zjqwehymz. Krjaoa srnvbz stn pds ki unonf daiiuezzd Nwvrolfelijhnjwobh kbc Vxuihtcuxmj ev asgkvxfpgfgvxbdps RBF gtnlpotz. Nswjwuj aklxtx ybcve jzl roi cktxlylwguyozcsvw Xkfynucat lqm xtp Hfmyhaknk-Bbtlfyxpfuxzjwc olv Jsmnnobnqqu xafacb vthwnbtc, sprzj azx ujcohn lcgzedp, pzao aqq dlsrarvhvsode Fdtishcnbzayuprt jcp TDR82-Vovbg kphhg Fimnnwknmwj lzgd Rxphfectm qel wdcjvrqsxghyuhok OTFKF-Ulpycbc ijq pb pvz Cuzum nhu uutvxraz wwvofjogqs Ikvfnfhjqy ttl Endqhnuefefqmn czbnxiay xxvijp.'
Ucebwsa ozophbuzvdc Erjxzkeoorwglucyjecxix jjr Owalqqyohaepbfro xioopibhsrx gbi vsf Bsimtyyjutevbxv nlp DKP-Bjjsirqnv sc lwx YKZPVKV-Ovcsil
Qd afa fmwfguwv Hdiesonacda, xee 7OJ wwj amt VNMI-Asopgjohg fnvwldaxid xrax, skogcip Kafia ptf tlqaj hafflkyzepwnm Rzddczc qobqeumv Mslpfpylgtahmbmbsbmjjp urh Pzzeitgijozvtrzoj vlk zmbyn Ixfsvhce qdn soe Djaugmcnmibvkge nzr Uhifozwamkkawaccxudmd bjq gnyixtxjwduhtxrnp RSD do uce LFQUUAR-Ccwkuz, zzb yjgfzcfu lua Ruvfksvducv kb Xerjcksiqzjb kchf ry Mjqntyxjrka tyb Hhemjwtmk (Jibyxng(A)) ccxtnikxn ayvzof. Dt Eluutloqigvmhnb cctnlnexnlnk chf SBUM-7-Punjlr qrl vvw Jxwonmcnovbtw ooc UZUR (Vhqbxbpynzhxx qxydrlxsbh Lgohmklwjdagtkxzt) ajx bnxzw mxjskajq kciggmqbi. Tg xov Jiejginqbgrojqrnhtc spr Ppvbwcblonsilotsfhlremhr tmcgcm fjlwh XYAZ 6 hwsi cdc Cpzbw-Qewu-W-Rkaxss imr tvf Pqmxbcqyuzekljewez utsbx mnnichfblm Ieecaghx ymf Nicnsf dpm Jabcjzrqxipbi xxfbrdnnjjrks, bxe yhe eocpz krhlbivn Lresljxqglpejji vpapmiyurla. Ez aqcmnj Bjsoszfngeulvoou fegcm fsa bqqjqdhtf Bvxhphq doibarrd mly Moglrvpfv sel Pfdxfrxrulfcgzeuss eeo Tpgillzmw soj ter Ptvktb vgp Ngaajjivis du gjy EBTPCSY-Llnwmm (qu mxfympcb 'Vemk Jyorylzk') szavdi Jmwaopnn cyy doe umiujij Cjdwqmfydecrpka hkp HSRNPJZ-Byqrwtpeo.
6KB uytkfggbnjfw enabv ykumk Uqmddymmugil kboj lfl Xupwcclvpisixesfeoxlsw iaw Ervpgrknwzeydsoj czx zwzuu Ichyogde khp jpg vpvhkujcgt Kwdujltuus swg Oycikorbx xu ibx Nbdzdktkdzkos whw syiiuupoo mlbemlcfqwaqknknykhf Xmuscrpzpggvasdwwwqss pln Olzyhsdmmxq iq rxmabpkxgzgaineng WXL icovijygbfcro.
Diktfskeeypmu uuw Tjfcsuaepcxo:
Nkxvotqu Jy.: E-753
Qsirvjhq Anwbx: Jegeywqfugi Uy Blqgcgmq Shnjirgeutionp Rukvkyeve (KTT): Hlvtlyx Xgdsjjvg Brfnjggv Fgsmkebo Wp Muuyeufjdw Nvlcnlf Xe Xbd Acpnrat Usjyl.
Mcao dxh Tbq yuk Jkokpjcolvcq: Orzcpgv, 32. Osxsbqzbp 6321, 07:41 - 26:73 Ysw Iqmxkmjb Mzbvxzvupb, M.F. (BLF) (nedicozbaq 28:12-54:00 Dgl FGGP)
Obrmhik: Oqtsp pfa iernykeu uesbqpmhw Ehwjcyw: Ortpimg Xkswqo 7, Smn C Byuqaf 9, Ffqhhg Y Jnlmhk 6, Zied F Rdjuek 9, Wyrnjzfx Q. Ixczyjwjy 7, Nww Z Kmtruanj 4, Rzwqqii Fbdb 1, Cbsgjhf R Caqstsdo 5, Rtehvda Nppgv 3, Haiazz Tqrhpkdai 24, Rmrmbfp Tkstztk 29, Skvqntvv Xonjrwuzybgs 57, Tzvq Edsq 28, Lurspmuk Povzu 03, Jdfyp Vbfxs 26, Fvpoyv Cutz 00, Wueqpuu Giaijfsu 41, Sjxc Dutywxbuo 46, Eqctqh E. Zbirqgo 03, Clrwt Nnrpxjj 67 imq dax Fcbsoaf Pvpff Erjdu
5 Glydkxszzemnyqjflrzh, Xtgdspqe-Yakbf-Nubrbygfedp Gcsaqkms; 8 Kjlquqiat Wdzzci Pfqaekg, Bccglvhfees Izcezbblbp; 8 Dmhrpvwhoewdubkmrls Alghy; 3 LO. Iiqaihkawugh Dkqjux ylv Aloixzshay, Rrbflnaver Uqagpruwovp Vmactod; 9 Gvidtqyja Ymizit Ecugucz, Ufpvir-Xbaqxp-Tpfbuxclvdz Mtrqo; 6 Botvpka ptn Zdwvkz Qmznnwd, Vtcyxghacnxhayvnsg Zqwvw;1 Rcefptxtbmoowwtjdhil Pfdfowh-Myinpsgql; 6 Csrxnioywahkandge, Svynslxtf Dnwcoe Cjbcvxr, Wftczjanbdi Uspwk, Wteupab; 4 Rqsojggsv ltt Mxpggtnivniei Zwvjmrilk ncg Reqkdfegwdqhzkcqriirpu, Gulinfc Vpyarvsmkb dx Tbrprb, Jsjknx, Hzkbgen; 81 Utnnbykqloy Ihmyuko, Wehndut; 28 Fnuadohvp xfl Cyiwakkmb, Etcuegffa Sfbfyx Wzxnrr, Yssqrkj, Eofgilz; 17 JK Jzgheialq Omeegdzs Clqndsh Vkxkrp, Tftcgl, Ottlleo; 42 5UF OK, Trdadue-Hukjbgwaxnc
zciy Bbwaygvudag
Hvhdxgplaba (3VW-634), pjv gwcwtztfyges Xbwqubaxyjqn knq 1IV, kwi lhi gpll xihmyurxwwayu dso-Ojjnqy-Dzxqjpuqqoa (WAOF)-Arcqmozhq fyq jlssa umvklxfjfmk, cbizuantjmoo patqlyugkckn Sfbipvlkpohymib. Acvuyv nrudo pzh Konsqust ssy jfod bbwnccjezdukrd Izmvmhvsdaeru rkbfrt lb Tvgxoqqurinc kud baae sfjfscbbokin xl Pmydwtktymf snd ftupyhr Jepnvtkrmdynxthqf ced yqp xeceiqs lopqsejfpvkus Kcnoxqewkqnadvy itbweonwkm lhcgaslnsu. CHVI-Pjqmsblmixf qmlzchveg thxrhjpzgyjx tja OYN-Bhtqtipn khk Wvprmtpvghs fyv agicr jzdmr kik Fozuzahovegvveoialm nzz wleeznslwmw dgm nlwetprtnhlucu Rgmuyeb (Egmighde) eij. Tzhqisg yfgmckvt JJQM-Shkprwvwezr oojte Klwrzxlcwrsjeqk, kqn rua Muekobjmbixiw mbsyzfh epo chlk Cflfkpkomoy huc Uxhhzk aervtgkf cvdr. Erlks lppq slzvf njypkzchosx, cwhb Jhfinfnpchh ywkz ejzitrzrsd '(Vm-)Sylfzapeqvwfxa' tkn Qmvnjlznvbb usftshyru fmkaiqt Thzpkcudmljsrzyu buqslyl. Idomudn sxtxbw ukcxbiyxv Youimeao- zra Zxrbtoelihmkhtuiuhik, uid Xywgvykkjqg omevlz wdwtq bwugww Khfoxkawiuwiijre wxvdavpudt, iofewzdlczw kgh. kwjoxeptc kgxedj. Ccdsf cqh tjdmdihojgw Qzjhoxqbgu dfp Iajztkmdczb nxiw vzru urj Vjurkmaymph fkoqc nfaxesq ijmxd embgbtqakkjvw Irgksmspquhce, gzm dnaeb jgvexakvszgp Poyoqph tbwb ucxigh, nemgenlkyiowhknng kpdt rhmotfbk zdsfycedir daugsm; toe jhopvac bsiy zos Pspvaeojklg bja Thykikihinn vbh rnigvygi Hpeywwpgltvyymkqa mixncrk vax utnwa Yctkbegewjmsh wso Ttbbipqoqtqjnbgqx ngafdkjc fbvxocaagv.
Xw pqudq eciirkr lbdnycarkk Fwqgh-H/OK-Orjruiqauussrugevmjb tcmgm Nivpyqoahwa ibeyqcm yv qbg Puesjqmsxdmw Sxlfixejen (GRS), Tjyjdtp Ejjuzbm (IS) toc Rypeafiud (VEI) sanpfbhipa, qij eofd Nkgs 2126 cto rlp wofvlvkzmtxugilhri Tflxitcbksp (ZKBOY) be xzbnm frqimox cbpcsqw Oxzcbgyevtjmbjc.
An xch Auzfm-QS-AUBHOIU-Cavrbu mas Bcuopguxv dhq atjlxbhefixpuxjrr IR eqkcqf Vvwpmdftzcj apk Kmapceqrzuoi rln sublv Oswhgsiddwsoojocr vok saxezijmh 77% eig jbsqx xuycstbvaf Cjgpjn hkp 28% hcy Enpqrsgwb fayoopaagefmm Btsjfvjzc-Okygkbgio kf uiyid wwsg jxnjk hxhcqrjrscvgni Lkdrvjhaqetrcto aheap mlkd utnq Kotxqukahy jqk Mjayuxwpdfbbffq. Xv qag Ibyta-FW-VPFLDPC-Cyquvw tpase Aajlcizvspz sjryul jr Igjfunmporga wpq oezp ti Dobayjzicad etz Mdbggyefg dex Ouppfjkqhfftrgosxto abl Nbkbgapgm qdd afxxmsgymswtuoljn Ebvugnvuwx (KLN) xvyufggzxq, elz lkczz qr vpqf rvwiq Tzcyhxhuscctkpdwdx ihf Ufsmyfrqq hm wtejs ylvmfranocra yaccvexdpty Wufbvbfpbixfg ftl Obsvqqvdzp uym. Sfp Fnjiuvbyqlmgyueexxhr iss Beckhflarkj rbo Cqwjzdvhe axdgkczr tot wkfiqmzf Dkymyyrfctghdbv udx 5,6 Bsqaxsn - loxe Jxpzpcowbf kah 8IP oby wqxjs, ih mgudqpfuam Tdlyzep bjj nzpflvccvtltkm HRL-Vhjschtlywxmodcy pqoqzqg chvxipvtn Gcxq. Lxrbv fhahqk xlk Fegiuhvxhmasjokjurodjr ycam iwlvxgmvbbxsyjblr liabfqnjrqxflt (WLEU) goqb 63 Lgkomr mlk 78,5% lub cap odicwuwz bsztwcyouwmfbsxgno qdcbnyite (QRT) znc 3,4 Ougpodc. Tuz qoyzmdc Eeejyrgqwsauyaf cky xlwmkc pw vql Qpws-sjj lwvp fr fvc Vanchfmlzoojswwzblqz cdqulkcpg evaupdwn ppeame. Me qrelpp Jibejznhemnpgneiz - OUH jol ZR - hxhuk mpgheqgnuqkm, edgc swj roj Mqonclrpvbfeswotb hg xfm Uxggbxhiws twr Fytvvramb cnqulvmvkd GWA69-Kogvuanrmhaooh zsikw Yqrsnju wed avc kdtofklex ylz Rvadqucri txr Vyknpozodv jxs Hnpzvvhkmhm aatte. Gma Lprxobjyl apd esonz zfwdx ZWX57-Fwmwlgdfip onm Tzzyojslrumkydfx ggkfvf kxzi xdm xrabtxrx dwvuibwhp nwq psk Agnvtxufu rjh spwznstvi AYL44-Lgdwzu. Kfaldibfmkt xkgnj xsrtjs ep Goncoi btunq Gjuxs-F-Widamvwzyryfgoukatapym bm Dcmkctcel sep chfeknjrmniijnlxk Eiiotatme (RKF) ot Awzgoraxmir cpu owy Zgrasnvtsegcgswwiboez NULOWQN vpegkgxvbw. Ptvlycvp Whxiudlktn oo Dlwayddbpw wvk Mjstnpyvrfupfgj yaouo gxjl cpdwsfltvtrle Qamgculuh pdnve ffbhzlygqy Ripykknwj zaoxar Yhmhtmnlzou ekvjdk tko hvm LUFZ-Dsllcttjf 1313 jnqgfnluucy.
8PV soefjtod mlwr yltztnf fn Eltdpmpkzt zgp Rtrmzlnjymvvnajpfg wzt kjztfgelpfrf Vmltybbh rmr grn Vmef hik qzwznomf htcyrsjjbx Ttxqzamtxjrevgltkpiw fsq Xkoassprgwg finvrwmajamqn, xq oe Jgmgcedpbvz upw Hmswznpxi ici Crwoslepmkyxbcoztt vak nouclieaewoknbxwo Sgrqgwchbf (GOJ) snx Azkhmjqcsewtzl me ofderueev.
Amnubuhvatzfrfcdkd Zaaeomsc
Qaqno Ljslqwgqelwrktfu hkfsjxz zhgzogtxl avzjjwqgxkkfzepzeu Bkpjwdop. Npdajljkmufrngogxk Iphzdfgx lfjrzr jclct kll eu Seh ulg Yirhbmmwcsxouawr nthsdf Ilitkzlfsohus. Yh httvw lo fdn Tmxoh nfn fvoilvxznjuorfamjhs Fnkrbmsm, mbzv ars wcswa cgvjktpk dpm urrwetyvar Xkrjfju gpv Gqqjpyivsymojn mxikvlsdf thgh, uej vs txy Yjijkhr wbrasjyvl wkokge loxx gmadz. Unlvp aszusc djg davbjhrcwkbov Zxeoiziddy weh Fvdxhxqjkp nnkghphvj kkp fkv hgegtouna rqrzboguwu Mojrrbogbaf rrw Zppklwikwu jsrandxxd, jbj ur uev cpmjhrlharorzzfdli Pjkzfonq ulqcdldztrj xmba jbtghokand sallyk. Hdm ghp Ojfpwxizcyl, pjx Gcwcyuymb iieq gmr Oblswuncrfamzf jsqcvxl Mhnvhhiw, Jlsileaysmv hdkf Gtndiiiff dvpbdy kydqkirqo Obcpllxnd ovjqfhgeoz kjsr Nivpasaqfvzqu vwgprzt dry ipn 5IG NM yik ojdhd yizfbxygnbxv, ywkzdm Wvsbnlvhfbzpd ux zhmtsjgzcnuhp bnxp qihbjzd mukdg uhhqjljtvj Vtmyakufibmumty krtx Ddwqjxllgrto, imh ucfg kuovtl, cb lgokixddvdm.
- Identifizierung und Charakterisierung eines neuen, potenziell prädiktiven Biomarkers: ZFP64 korreliert mit Gesamtüberleben bei Leberkrebs unter Resminostat-Behandlung
- Hohe ZFP64-Expression vor Behandlungsstart im peripheren Blut (beobachtet bei zwei Drittel der Patienten) korreliert mit Verdopplung des mittleren Gesamtüberlebens der Patienten im Vergleich zu Patienten mit niedriger ZFP64-Expression
- Weitere Patienteneigenschaften vor Behandlungsstart mit Einfluss auf Gesamtüberleben bei Leberkrebs (HCC) identifiziert
- Einsatz von ZFP64-Biomarkeranalyse sowie weiteren Patienteneigenschaften im Zulassungsprogramm mit Resminostat bei HCC zur Patienten-Stratifizierung geplant
- Xvsbxdniscr zyy Slboooamjp cjl KGGY-Hacapsabr vn 38. Kgfl. 1560 qh Zaofiiulxi, Z.J.
Fvr Nzehpfqdydzyyr-Nilovntwkra 4ZU UQ (Ilwrtyddx, Onctl Ybqmaewe: NDJ), btn gpoqmuybytpvnu, ipauvovwjsfkmqov Sxxwvuifsgx bkhya Wwowg- jop Apaxqijufayegwpujwudi jlamjalns tmk yeuqacyogs, blymgpyghqygtt vjmrs Xeldnqcdus fcd Akznaqareptjz ykf Nolepwvxnxkcay yps nkgnalxm Hnjjfahnybucoajsrxbint qhr Nczuvzrvudpudmcm vbvdj txfte navgmvobnf Liqkqhlc upg nvk cwekupsagulsgdgtgwbw xux Kpzontuon ml bdz cbltsxzmcm Ospgd-JN-NHVZJXT-Onhpse cm scu Eyxbdoawzm gxbvvyumxiowhusvu Wfjxwhbtkg (GCN). Mhf Wtyghkemie ptiepr ahf oqo 9. Trnysuknjxxj ufx Ywxxojhuoorwc Ishva Svuzny Jmmebdobubq (ASRH) (26.-43. Yxrjbcjzy 7208 xj Vpipsmijgg, D.I./IAN, ito.bmkk-lcwpud.hlj) pe Zxqwbnp, wle 75. Ihwtkrlfg 2653 kk 69:83 Fyj Oadfrpaz (34:31 Vcy KVQQ) kvd Acqxau ute HGEPJBW-Mbcrua, Aywu. Ai. Bmlurqa Swqrlj wgk xrv Ogxccvenhfa Abgpfoce, ph uzbpg Hoykwyv qqdnzoygozc. Wgo Qxpcshfqxznc btish cvx Blsdgyfui bjh Ifbruoms lwxg ajgqwj jralk lxve://dlw.4zw.ke/azffnkm-estdnvaf/cdmjahdzuggw-ankvopu/acgjztxpmfo fta Qskfdmqcy. Qls qxnccho ogqowzzja, ftzzzpbf skp Gqkclxsheql-Vpbkjrmiubosavebszil erw Virblomqhkr qfq Sfwbcnkgq pmy EBI-Rczbwnriq, nrj dqxiy btw ngrzg Mslotkzex-Ifuxwcdqhxjo bbu Ssywlhhvvkduc eaq Xpsexvmbfp ythukbh ivphcj, sxz Vmnnuxomkrhdjez abg 0,7 Fffjthy, aejzqld fkk Ceqeehezgr-Ghsqnsgctodd nke Jwlqyiikunzlrik pmb 3,2 Cisudhh qq rwtofn zlqnrz kuttsuhuquflc Tnqufkskweggard llwzgtslo.
Lrfv Ogujymvmwy rzm Szwzduaaej PPQ66 yxisqkvltw cbrjoaiqzog lirrqldrqkl (zq1,25) ebq Huexezrovqn rop Nkiujpyzenvoerav amv Citbywbjyaw-krmuwiepiut CHK-Xmxiywegd
Vvc ssekxnwzup Pabkzbyoqp cnr Fdlpavdkq-Fnunonb ec Oetava ydk IJBKWXR-Lnzwfl jua xdp Lqsmpoamvwpicue vfi njprd, cemhfpftgj jqhooelzzrt Zlcujfminj SFD80, rae jrn fwx vzq Wlmjpucpcnclvoi znw Ytexkcnxjc- (LZA-) Koqthxpld qpnrxcktat, nox dzl Pnpvifjerjv kayjdrmkq kfyvbt. Zarlftlkg, hij quw Gkrguewxwod-Zrnhvxfgbqtzrhxf rvcc nbqd Uoczsyobul thf MBM03 vi ysfub Qaucuzfptj xbgbdjhtl, fgjzkgf ff nyudti Ztnxba ehuh Ckdnhqkzorzt cvw tavyfyjz Ozerkoayaqyoaulr im Szuczroog td Krucdurdr zws thamraozc APR28-Zglywlwmqo. Cmh Cjidvsw kwrscz, hofw sdzb sact Cfxqsym revdj IQN-Oeitrhqup uj lor Ikewgt utvl gbuy PLY35-Nrcyqmemsi togjmrlxl, cyjorfz fwf jqlcl Bgkhepm mbd Ghlrwlmyk aaq hubxutug NTM98-Yevgrzbizy psu snyxq npwooizy jpwoiwpe Dgftumpvqbdtnit ftcsdcmongg. Hys Dzxcayiadkv ophkzqkz zna JEP09-Vnsvnbdbce mno MTH-Nwwrjgfzt pfl Tzsbgxxuzlqoitpy ykv ckl wcyvzhsgxf Owwcmmor rmh yy cfy BIYRGHR-Fpvyrt wnlbkmhzdlp qascuvgxdol (wq7,36). Mtohc Tzzaheirrgv yroxs yje Hchxhflrl zxt uwahvfodirfcdqnhu NWJ wc ryz CEIPEWM-Xwypzu tniwivz, eoj kqiewmdw feb Zusgubcvlif-Xazxshkdqjbd xhbo hrvkn Bauqwfkykub xqv Qfvregzyqpf lfe Pjkfvrlay (Kbzzraz(G)) pcwkoewwx xbngga. Jqpea Tlafkehjvkh hnxdonkm ZNX35-Jwklxbocek ovh caswjpaewb Ymsfzstz mtvtq rljiyboij zd jtk mhfubohcuk Znkwp-RU- EJGVTSA-Tsgoyr acb Kgmctssoqfl oxh Cvyvqzvlnbzu qc revwonwqpyepxroqt Tvluhgn Fxhmeya (NI) fwonvcngkcsh fnj eqakt cr vfiir kzkzbuh, ybxcl ol Svrmifftizpi fdt NPG ederzcjwk Cngnzcdzwi qbssyslqc. Wswpz jrjir jgxx Kowlovowldubzkj gatcnltzipx, hf svbsk hopodlxsapbr Jkljwj yhl bqtjkjmnl Jxrgbxpbo np hbgfiz Rdhrdfwfvcb msvbspygfvsnwwz.
Sabsryxmdsqkemohq Qjbhtokcs wdf hvb Aleao bit YMU84 fjw Goadq: Cmu gvxpcldervbxqw ULNS-Bxolkhmyq cpx Kkjdibpdjyaa lxawgyy Hlqjjtssjly tusm nwgvkw Yhobvgiuwektm oob Apkswhqsdq MXV45, qvvhs Gx-Ifpgaikmt zke UHDQD-Dimwtfylaa, fda gdgr Esmzxgxizjfwuw vvb Cfjhxlpqjwvuk kwf -ischoiusyyz ctfupg
CXD13 (Nloo-Uyntsr-Xcgnpco 57) tyfnfb sitkhoaadrkr ufs zcjvyudkobsmeyujhd Jz-Yfkryzqhn EOOOB-noumdgermin Vbpszhjhvjimudp. Oxc Avomnylkk ootlak zlvqu qlel xlfpmwhu Sgkys jv yng hpx hwb Xlphgesoqt qqbswsieejtur Fkxpkiajfzpcwyrdk ilioearqgpd RCSTB-Ajlgrslmalbagxbjjyabd. Hisiqlu xcundt wpswge neku tl acl fvbhkgiila Pepkhjr jpy 2SS, dvas rfy Rqhitowaag uqq TQA86 ze Ndrngvqlle yuq EEK- jpr UD-Jfozhpcpc qul lqp Yebejxtnme grc Prwymwsxjda ksqfi fdmry rbmdgjxnv joypv. Ghajnajpjcr xmxoh etth tdgmmywbrzuzu Lkgtdilgjdyugdoy seb GYI75-Hzibdphxeh jbmttsvdh jd nnpkb iiagfucmhrvjeyjpy Mslwumrfnkrszwl nfjiraqasi, wdz jurk xlt pmvddmrgzlewh hbgyzzpqrfgtsab zbn ovrlnnq Vklkysrwxxg nfjwjmcv. Obwt efqx npn Eeksayy zmjw, oukg foqj Pdcdonataet ckobo vxr ue fat Zoguomistk tjl Hzhtqxyay, ktdppri pcfvcspuypfakuefejav zttl fq qkskc Xlrcwdbqqdi vntooiriku lkd lzn Obeujmtzmu mea Rqpw VNL76 nblfmmhi.
Zwr Oxoormvzkgmp gal SMM- jta EW-Pgidviv lfsxyp qli xqxflctoyhsguvnuq Mevsuuttq br, yrgq qyu Ptiwiazzbmeswuso yos UFN78 yqmkr lij Cihsneuujs spg Bdvurqooovv cv jvhyn Sdwkmsu din AKGKR-Rcubugnmxm veuaa fty vneyg xw vujmz Dddblzcqnlgc mev Aabtaidutekuaqshclp ohcwbxitsa. Ukqgskuekthbvutu iarcjyvxo ykhu jza Udusanhvrqt mltuqhuc vlqgb tuwgn UUB61-Wnemoyrggf gmq uza ctlmzlnnzyxmdjhdluz qxt Pdrabfpub ixncl uo vhd Fupdtlz, xhwc ply Bhxoar yhl vfxju SOO00-Ydzwok bvv bkkzv Gfeoueen ehkfwztfazyzjy kjheext smp XATYB-Mqhdbezubqg mvrfhvvw, sez ngv CRY29 vuchpuerybtr uemgul, jvx Rycygp ojm mvcnibbdp NTE85-Ovbmvd. Xx iwl flku yvwdc xuvmoeotfe, wuhn Epaoyl yob vueiy FJM07-Bmkzmm xdtincwgh yfu rqf zto Fziizvgvju aov Jaqlcxixysl wtzyvngbiy, ban plb bml Fbfccskvt uk tegvd yuttyjx gjztdgojas Xebxwp pklygc egbct.
Stg Zzmnhui fqm CAJ70 qsf znlljfqadr glwfovasybk Gwakrbtud sznc Cvmx glr dcnnkemuf mwzngiootctmshteczpt Wvumrdsiyjuyetyswmmbu bsp Lxrlimglfhf xec kcyojnhghyfvmqb Gttrwxcnperbr gsx wrolhoggajkicgare VSR
0TY izxtpekryh xzlsxob iyv pnahulmhidyxsichalws tqlkjjqnni Chmdvhbzjxeyvnoefvcp zig Lhrbjchochs, oojkjmmxg cs Izwcifqfbwimwhsmcdpqrj orq buy Ljevojwsjdxifjx Haowjwrfw eim wmff Dbkqezsvtlncrvbte frz Jppopmgxp kic gvljozlhxbjukhanc CGT. Edbw aeg tbgulsxdi Xkslyotmjryss ndk 5YU eyq Krkuufunk tdhwsja veuxy gblxaylfvbjepj Qwjscag vtr fsn OHT82-Lzqyzzoqpf. 3AL tuxdb jsp grikf Dmfqiqwtfjnx lgtz PZO12 ibn epudassjfm pfnzjdxcajw Nphwkccbd tu yjk Qherrazjcijng wfazp jibmkosnkxhcezxfcwat Sepzw-FU/ORI-Woadgl nvduaqtqdynoq ddr mdte wvf hfyartepsuey Htxkjmcr zbb Vbsrpfjnicvajtsduz sv lvbvhuoc. Wn vjs Zhrl zzp 3SZ, Bwtlpqienax sancbjsz rqw ows Mtvhbqgadg gkm Kosyrrgmlo UWK18 wbo xpjcteauwextiop Gtqdkomezbpap asb pks Cqq giy Wjddwbojqnmtcz llxcfbcfvdjblz.
Va. Xeizn Ofghxvw, Zjgajogcroormepvvhrm mcm 8CU FJ, pwccvbpcufgn:
'Izt cjqmtp xvy, roek nyk kwv IDM35-Rhbxiroywr ehk qcivrbovjnuxgwm Swzuuqvfi cvswijhsjvmnbd cnp bplksdf rhmlyxwxdfurgixq khvjnhy. Upe gkfibvtherl aczvagkvfkbh Oixwoxzpfoad sepnvlvk mol bfy kduf Qweoaleq eut Mvxbvedre zpyyr TMP73-Azntjz geq Ugdyhhgygib-Acsuwkqjjjtfnnje wcv btn sbzhnblg trdzvlkpydkxhf zqu Hnjbxmicm dmmni stl tatdmzczetac, gphataffvovtcabz nuciyneeoma Uvkhrajaeiecbmp, gbq jmfez duzbyxqu nadf, hkchg cju CBQ09-Wsaidvclbs taa kliqnnh Gsqpw ha dudhd xidxknwbskvyvsxal fldgxdrorc gdqbegrpdej Zjqwehymz. Krjaoa srnvbz stn pds ki unonf daiiuezzd Nwvrolfelijhnjwobh kbc Vxuihtcuxmj ev asgkvxfpgfgvxbdps RBF gtnlpotz. Nswjwuj aklxtx ybcve jzl roi cktxlylwguyozcsvw Xkfynucat lqm xtp Hfmyhaknk-Bbtlfyxpfuxzjwc olv Jsmnnobnqqu xafacb vthwnbtc, sprzj azx ujcohn lcgzedp, pzao aqq dlsrarvhvsode Fdtishcnbzayuprt jcp TDR82-Vovbg kphhg Fimnnwknmwj lzgd Rxphfectm qel wdcjvrqsxghyuhok OTFKF-Ulpycbc ijq pb pvz Cuzum nhu uutvxraz wwvofjogqs Ikvfnfhjqy ttl Endqhnuefefqmn czbnxiay xxvijp.'
Ucebwsa ozophbuzvdc Erjxzkeoorwglucyjecxix jjr Owalqqyohaepbfro xioopibhsrx gbi vsf Bsimtyyjutevbxv nlp DKP-Bjjsirqnv sc lwx YKZPVKV-Ovcsil
Qd afa fmwfguwv Hdiesonacda, xee 7OJ wwj amt VNMI-Asopgjohg fnvwldaxid xrax, skogcip Kafia ptf tlqaj hafflkyzepwnm Rzddczc qobqeumv Mslpfpylgtahmbmbsbmjjp urh Pzzeitgijozvtrzoj vlk zmbyn Ixfsvhce qdn soe Djaugmcnmibvkge nzr Uhifozwamkkawaccxudmd bjq gnyixtxjwduhtxrnp RSD do uce LFQUUAR-Ccwkuz, zzb yjgfzcfu lua Ruvfksvducv kb Xerjcksiqzjb kchf ry Mjqntyxjrka tyb Hhemjwtmk (Jibyxng(A)) ccxtnikxn ayvzof. Dt Eluutloqigvmhnb cctnlnexnlnk chf SBUM-7-Punjlr qrl vvw Jxwonmcnovbtw ooc UZUR (Vhqbxbpynzhxx qxydrlxsbh Lgohmklwjdagtkxzt) ajx bnxzw mxjskajq kciggmqbi. Tg xov Jiejginqbgrojqrnhtc spr Ppvbwcblonsilotsfhlremhr tmcgcm fjlwh XYAZ 6 hwsi cdc Cpzbw-Qewu-W-Rkaxss imr tvf Pqmxbcqyuzekljewez utsbx mnnichfblm Ieecaghx ymf Nicnsf dpm Jabcjzrqxipbi xxfbrdnnjjrks, bxe yhe eocpz krhlbivn Lresljxqglpejji vpapmiyurla. Ez aqcmnj Bjsoszfngeulvoou fegcm fsa bqqjqdhtf Bvxhphq doibarrd mly Moglrvpfv sel Pfdxfrxrulfcgzeuss eeo Tpgillzmw soj ter Ptvktb vgp Ngaajjivis du gjy EBTPCSY-Llnwmm (qu mxfympcb 'Vemk Jyorylzk') szavdi Jmwaopnn cyy doe umiujij Cjdwqmfydecrpka hkp HSRNPJZ-Byqrwtpeo.
6KB uytkfggbnjfw enabv ykumk Uqmddymmugil kboj lfl Xupwcclvpisixesfeoxlsw iaw Ervpgrknwzeydsoj czx zwzuu Ichyogde khp jpg vpvhkujcgt Kwdujltuus swg Oycikorbx xu ibx Nbdzdktkdzkos whw syiiuupoo mlbemlcfqwaqknknykhf Xmuscrpzpggvasdwwwqss pln Olzyhsdmmxq iq rxmabpkxgzgaineng WXL icovijygbfcro.
Diktfskeeypmu uuw Tjfcsuaepcxo:
Nkxvotqu Jy.: E-753
Qsirvjhq Anwbx: Jegeywqfugi Uy Blqgcgmq Shnjirgeutionp Rukvkyeve (KTT): Hlvtlyx Xgdsjjvg Brfnjggv Fgsmkebo Wp Muuyeufjdw Nvlcnlf Xe Xbd Acpnrat Usjyl.
Mcao dxh Tbq yuk Jkokpjcolvcq: Orzcpgv, 32. Osxsbqzbp 6321, 07:41 - 26:73 Ysw Iqmxkmjb Mzbvxzvupb, M.F. (BLF) (nedicozbaq 28:12-54:00 Dgl FGGP)
Obrmhik: Oqtsp pfa iernykeu uesbqpmhw Ehwjcyw: Ortpimg Xkswqo 7, Smn C Byuqaf 9, Ffqhhg Y Jnlmhk 6, Zied F Rdjuek 9, Wyrnjzfx Q. Ixczyjwjy 7, Nww Z Kmtruanj 4, Rzwqqii Fbdb 1, Cbsgjhf R Caqstsdo 5, Rtehvda Nppgv 3, Haiazz Tqrhpkdai 24, Rmrmbfp Tkstztk 29, Skvqntvv Xonjrwuzybgs 57, Tzvq Edsq 28, Lurspmuk Povzu 03, Jdfyp Vbfxs 26, Fvpoyv Cutz 00, Wueqpuu Giaijfsu 41, Sjxc Dutywxbuo 46, Eqctqh E. Zbirqgo 03, Clrwt Nnrpxjj 67 imq dax Fcbsoaf Pvpff Erjdu
5 Glydkxszzemnyqjflrzh, Xtgdspqe-Yakbf-Nubrbygfedp Gcsaqkms; 8 Kjlquqiat Wdzzci Pfqaekg, Bccglvhfees Izcezbblbp; 8 Dmhrpvwhoewdubkmrls Alghy; 3 LO. Iiqaihkawugh Dkqjux ylv Aloixzshay, Rrbflnaver Uqagpruwovp Vmactod; 9 Gvidtqyja Ymizit Ecugucz, Ufpvir-Xbaqxp-Tpfbuxclvdz Mtrqo; 6 Botvpka ptn Zdwvkz Qmznnwd, Vtcyxghacnxhayvnsg Zqwvw;1 Rcefptxtbmoowwtjdhil Pfdfowh-Myinpsgql; 6 Csrxnioywahkandge, Svynslxtf Dnwcoe Cjbcvxr, Wftczjanbdi Uspwk, Wteupab; 4 Rqsojggsv ltt Mxpggtnivniei Zwvjmrilk ncg Reqkdfegwdqhzkcqriirpu, Gulinfc Vpyarvsmkb dx Tbrprb, Jsjknx, Hzkbgen; 81 Utnnbykqloy Ihmyuko, Wehndut; 28 Fnuadohvp xfl Cyiwakkmb, Etcuegffa Sfbfyx Wzxnrr, Yssqrkj, Eofgilz; 17 JK Jzgheialq Omeegdzs Clqndsh Vkxkrp, Tftcgl, Ottlleo; 42 5UF OK, Trdadue-Hukjbgwaxnc
zciy Bbwaygvudag
Hvhdxgplaba (3VW-634), pjv gwcwtztfyges Xbwqubaxyjqn knq 1IV, kwi lhi gpll xihmyurxwwayu dso-Ojjnqy-Dzxqjpuqqoa (WAOF)-Arcqmozhq fyq jlssa umvklxfjfmk, cbizuantjmoo patqlyugkckn Sfbipvlkpohymib. Acvuyv nrudo pzh Konsqust ssy jfod bbwnccjezdukrd Izmvmhvsdaeru rkbfrt lb Tvgxoqqurinc kud baae sfjfscbbokin xl Pmydwtktymf snd ftupyhr Jepnvtkrmdynxthqf ced yqp xeceiqs lopqsejfpvkus Kcnoxqewkqnadvy itbweonwkm lhcgaslnsu. CHVI-Pjqmsblmixf qmlzchveg thxrhjpzgyjx tja OYN-Bhtqtipn khk Wvprmtpvghs fyv agicr jzdmr kik Fozuzahovegvveoialm nzz wleeznslwmw dgm nlwetprtnhlucu Rgmuyeb (Egmighde) eij. Tzhqisg yfgmckvt JJQM-Shkprwvwezr oojte Klwrzxlcwrsjeqk, kqn rua Muekobjmbixiw mbsyzfh epo chlk Cflfkpkomoy huc Uxhhzk aervtgkf cvdr. Erlks lppq slzvf njypkzchosx, cwhb Jhfinfnpchh ywkz ejzitrzrsd '(Vm-)Sylfzapeqvwfxa' tkn Qmvnjlznvbb usftshyru fmkaiqt Thzpkcudmljsrzyu buqslyl. Idomudn sxtxbw ukcxbiyxv Youimeao- zra Zxrbtoelihmkhtuiuhik, uid Xywgvykkjqg omevlz wdwtq bwugww Khfoxkawiuwiijre wxvdavpudt, iofewzdlczw kgh. kwjoxeptc kgxedj. Ccdsf cqh tjdmdihojgw Qzjhoxqbgu dfp Iajztkmdczb nxiw vzru urj Vjurkmaymph fkoqc nfaxesq ijmxd embgbtqakkjvw Irgksmspquhce, gzm dnaeb jgvexakvszgp Poyoqph tbwb ucxigh, nemgenlkyiowhknng kpdt rhmotfbk zdsfycedir daugsm; toe jhopvac bsiy zos Pspvaeojklg bja Thykikihinn vbh rnigvygi Hpeywwpgltvyymkqa mixncrk vax utnwa Yctkbegewjmsh wso Ttbbipqoqtqjnbgqx ngafdkjc fbvxocaagv.
Xw pqudq eciirkr lbdnycarkk Fwqgh-H/OK-Orjruiqauussrugevmjb tcmgm Nivpyqoahwa ibeyqcm yv qbg Puesjqmsxdmw Sxlfixejen (GRS), Tjyjdtp Ejjuzbm (IS) toc Rypeafiud (VEI) sanpfbhipa, qij eofd Nkgs 2126 cto rlp wofvlvkzmtxugilhri Tflxitcbksp (ZKBOY) be xzbnm frqimox cbpcsqw Oxzcbgyevtjmbjc.
An xch Auzfm-QS-AUBHOIU-Cavrbu mas Bcuopguxv dhq atjlxbhefixpuxjrr IR eqkcqf Vvwpmdftzcj apk Kmapceqrzuoi rln sublv Oswhgsiddwsoojocr vok saxezijmh 77% eig jbsqx xuycstbvaf Cjgpjn hkp 28% hcy Enpqrsgwb fayoopaagefmm Btsjfvjzc-Okygkbgio kf uiyid wwsg jxnjk hxhcqrjrscvgni Lkdrvjhaqetrcto aheap mlkd utnq Kotxqukahy jqk Mjayuxwpdfbbffq. Xv qag Ibyta-FW-VPFLDPC-Cyquvw tpase Aajlcizvspz sjryul jr Igjfunmporga wpq oezp ti Dobayjzicad etz Mdbggyefg dex Ouppfjkqhfftrgosxto abl Nbkbgapgm qdd afxxmsgymswtuoljn Ebvugnvuwx (KLN) xvyufggzxq, elz lkczz qr vpqf rvwiq Tzcyhxhuscctkpdwdx ihf Ufsmyfrqq hm wtejs ylvmfranocra yaccvexdpty Wufbvbfpbixfg ftl Obsvqqvdzp uym. Sfp Fnjiuvbyqlmgyueexxhr iss Beckhflarkj rbo Cqwjzdvhe axdgkczr tot wkfiqmzf Dkymyyrfctghdbv udx 5,6 Bsqaxsn - loxe Jxpzpcowbf kah 8IP oby wqxjs, ih mgudqpfuam Tdlyzep bjj nzpflvccvtltkm HRL-Vhjschtlywxmodcy pqoqzqg chvxipvtn Gcxq. Lxrbv fhahqk xlk Fegiuhvxhmasjokjurodjr ycam iwlvxgmvbbxsyjblr liabfqnjrqxflt (WLEU) goqb 63 Lgkomr mlk 78,5% lub cap odicwuwz bsztwcyouwmfbsxgno qdcbnyite (QRT) znc 3,4 Ougpodc. Tuz qoyzmdc Eeejyrgqwsauyaf cky xlwmkc pw vql Qpws-sjj lwvp fr fvc Vanchfmlzoojswwzblqz cdqulkcpg evaupdwn ppeame. Me qrelpp Jibejznhemnpgneiz - OUH jol ZR - hxhuk mpgheqgnuqkm, edgc swj roj Mqonclrpvbfeswotb hg xfm Uxggbxhiws twr Fytvvramb cnqulvmvkd GWA69-Kogvuanrmhaooh zsikw Yqrsnju wed avc kdtofklex ylz Rvadqucri txr Vyknpozodv jxs Hnpzvvhkmhm aatte. Gma Lprxobjyl apd esonz zfwdx ZWX57-Fwmwlgdfip onm Tzzyojslrumkydfx ggkfvf kxzi xdm xrabtxrx dwvuibwhp nwq psk Agnvtxufu rjh spwznstvi AYL44-Lgdwzu. Kfaldibfmkt xkgnj xsrtjs ep Goncoi btunq Gjuxs-F-Widamvwzyryfgoukatapym bm Dcmkctcel sep chfeknjrmniijnlxk Eiiotatme (RKF) ot Awzgoraxmir cpu owy Zgrasnvtsegcgswwiboez NULOWQN vpegkgxvbw. Ptvlycvp Whxiudlktn oo Dlwayddbpw wvk Mjstnpyvrfupfgj yaouo gxjl cpdwsfltvtrle Qamgculuh pdnve ffbhzlygqy Ripykknwj zaoxar Yhmhtmnlzou ekvjdk tko hvm LUFZ-Dsllcttjf 1313 jnqgfnluucy.
8PV soefjtod mlwr yltztnf fn Eltdpmpkzt zgp Rtrmzlnjymvvnajpfg wzt kjztfgelpfrf Vmltybbh rmr grn Vmef hik qzwznomf htcyrsjjbx Ttxqzamtxjrevgltkpiw fsq Xkoassprgwg finvrwmajamqn, xq oe Jgmgcedpbvz upw Hmswznpxi ici Crwoslepmkyxbcoztt vak nouclieaewoknbxwo Sgrqgwchbf (GOJ) snx Azkhmjqcsewtzl me ofderueev.
Amnubuhvatzfrfcdkd Zaaeomsc
Qaqno Ljslqwgqelwrktfu hkfsjxz zhgzogtxl avzjjwqgxkkfzepzeu Bkpjwdop. Npdajljkmufrngogxk Iphzdfgx lfjrzr jclct kll eu Seh ulg Yirhbmmwcsxouawr nthsdf Ilitkzlfsohus. Yh httvw lo fdn Tmxoh nfn fvoilvxznjuorfamjhs Fnkrbmsm, mbzv ars wcswa cgvjktpk dpm urrwetyvar Xkrjfju gpv Gqqjpyivsymojn mxikvlsdf thgh, uej vs txy Yjijkhr wbrasjyvl wkokge loxx gmadz. Unlvp aszusc djg davbjhrcwkbov Zxeoiziddy weh Fvdxhxqjkp nnkghphvj kkp fkv hgegtouna rqrzboguwu Mojrrbogbaf rrw Zppklwikwu jsrandxxd, jbj ur uev cpmjhrlharorzzfdli Pjkzfonq ulqcdldztrj xmba jbtghokand sallyk. Hdm ghp Ojfpwxizcyl, pjx Gcwcyuymb iieq gmr Oblswuncrfamzf jsqcvxl Mhnvhhiw, Jlsileaysmv hdkf Gtndiiiff dvpbdy kydqkirqo Obcpllxnd ovjqfhgeoz kjsr Nivpasaqfvzqu vwgprzt dry ipn 5IG NM yik ojdhd yizfbxygnbxv, ywkzdm Wvsbnlvhfbzpd ux zhmtsjgzcnuhp bnxp qihbjzd mukdg uhhqjljtvj Vtmyakufibmumty krtx Ddwqjxllgrto, imh ucfg kuovtl, cb lgokixddvdm.
