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Roche Applied Science Launches the E-Plate Insert for Analysis of Cell-Cell Interactions using the xCELLigence System
, Forschung und Entwicklung, Roche Diagnostics GmbH
Co-cultivation can be used in a wide variety of applications, including cell signalling and toxicology testing. A key goal in drug discovery is to identify how to...
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Roches xCELLigence Cardio Instrument misst Schlagrhythmus und proarrhythmische Wirkungen von Substanzen in aus Stammzellen erzeugten Kardiomyozyten
, Forschung und Entwicklung, Roche Diagnostics GmbH
Wissenschaftler des University Medical Center Utrecht in den Niederlanden und der Abteilung Bioscience der Forschungsabteilung von Astra Zeneca in Mölndal (Schweden)...
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Roche's xCELLigence Cardio Instrument Used to Detect Beating Rhythm and Proarrhythmic Effects of Compounds in Stem Cell-Derived Cardiomyocytes
, Forschung und Entwicklung, Roche Diagnostics GmbH
In an effort to improve preclinical cardiotoxicity assays, reduce drug testing attrition rates, and ensure drug safety, collaborating scientists at the University...
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Roche's xCELLigence System Monitors Beating Periodicity of Stem Cell Derived Cardiomyocytes in Preclinical Safety Assessment
, Forschung und Entwicklung, Roche Diagnostics GmbH
Cardiac toxicity is a major concern in drug development and it is imperative that clinical candidates are thoroughly tested for adverse effects earlier in the drug...
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Roche's xCELLigence RTCA Cardio Instrument Used to Estimate the Risk of Drug-induced Proarrhythmia in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
, Biotechnik, Roche Diagnostics GmbH
Cardiotoxicity, which results when drugs adversely affect the heart, explains why roughly one third of new pharmaceuticals are withdrawn from the market and why...
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Roche's xCELLigence RTCA HT System: Fully-automated Measurement of Therapeutic Targets' Cellular Activity
, Forschung und Entwicklung, Roche Diagnostics GmbH
Label-free technologies have entered the stage of cellular drug discovery and high-throughput screening (HTS). For the measurement of G protein-coupled receptor...
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AgenoLAB Broadens Service Offering for Drug Development with Roche's RTCA Cardio Instrument
, Medizintechnik, Roche Diagnostics GmbH
AgenoLAB, the Stuttgart-based service provider, is the first company in Germany to expand its service offering with the latest cell analysis technology from Roche...
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ACEA Biosciences, Inc. Announces New Patent; Broad Claims Granted for Cytotoxicity Profiling and Chemical Compound Testing on the xCELLigence System
, Biotechnik, Roche Diagnostics GmbH
ACEA Biosciences, Inc., a pioneer in the development of high-performance microelectronic systems for cell-based assays, diagnostics, and pharmaceutical research,...
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The Missing Link: Roche's E-Plate VIEW Joins Impedance-based Real-time Monitoring with Visual Inspection of Cells
, Forschung und Entwicklung, Roche Diagnostics GmbH
The new E-Plate VIEW 96 from Roche (SIX: RO, ROG; OTCQX: RHHBY) offers the first time possibility to combine label-free real-time monitoring of cells with visual...
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Real-Time Detection of Neuronal Cell Death by Impedance-Based Analysis using the xCELLigence System
, Biotechnik, Roche Diagnostics GmbH
Time course analyses of neuronal cell death and its underlying mechanisms require laborious experiments and multiple endpoint assays, often involving labelling with...
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Functional Cell Profiling of Endogenous GPCRs using the xCELLigence System
, Biotechnik, Roche Diagnostics GmbH
Gcoupled protein receptors (GPCRs), also known as 7transmembrane proteins, constitute the single largest class of therapeutic targets for clinical and investigational...
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Measurement of Compound-Induced Cytotoxicity with Roche's xCELLigence Real-Time Cell Analysis System
, Biotechnik, Roche Diagnostics GmbH
Monitoring of cell viability and toxicity are critical to many areas of biological and biomedical research. This is true for understanding the molecular and biochemical...
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Non-Invasive Real-time Monitoring of Membrane Cholesterol Dynamics in Human Keratinocytes with Roche's xCELLigence System
, Forschung und Entwicklung, Roche Diagnostics GmbH
In a recent study initiated by Beiersdorf AG (1), Florian Spörl and colleagues evaluated the use of Roche Applied Science's (SIX: RO, ROG; OTCQX: RHHBY) xCELLigence...
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Roche xCELLigence System for Cell Analysis to Provide Predictive Mechanistic Information for Small Molecule Compounds
, Biotechnik, Roche Diagnostics GmbH
The extent to which protein targets are modulated by drugs or small molecule compounds depends on a number of factors, including the expression levels of the target,...
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Roche Completes xCELLigence Family of Products with the New, Highly Flexible xCELLigence RTCA DP Instrument
, Biotechnik, Roche Diagnostics GmbH
Following the launches of the xCELLigence RTCA SP Instrument and the RTCA MP Instrument last year, Roche Applied Science has now completed its xCELLigence Real-Time...
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