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The Missing Link: Roche's E-Plate VIEW Joins Impedance-based Real-time Monitoring with Visual Inspection of Cells
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The new E-Plate VIEW 96 from Roche (SIX: RO, ROG; OTCQX: RHHBY) offers the first time possibility to combine label-free real-time monitoring of cells with visual inspection in one device. E-Plate VIEW 96, a modified version of the E-Plate 96, is a single use, disposable device used for performing cell analysis assays on the Real-Time Cell Analyzer (RTCA) Single Plate (SP) and Multiple Plate (MP) Instruments. It enables for downstream or intermediate visual inspection of cells using microscopes and automated cell imaging systems like Roche’s Cellavista Instrument. Precise quantitative information is provided during all phases of comprehensive experiments about the status of cells: including cell number, cell adhesion, cell viability, and cell morphology. A label or fixation of cells is not needed.
For the modification, four rows of microelectrode sensors were removed in each well to form a “window” for visual inspection. The gold electrode covers approximately 70 % of the bottom area. The E-Plate VIEW 96 has identical outer dimensions as the E-Plate 96 and allows therefore working with both plates in parallel in RTCA SP and MP Instruments without adapters.
“The new E-Plate features an innovative and unique approach that allows combining impedance-based real-time monitoring with visual inspection of cells,” states Ruedi Stoffel, Life Cycle Leader Cellular Analysis of Roche Applied Science. “We expect that in the long run, the xCELLigence System with the E-Plate VIEW will become the platform of choice also for those users currently working with traditional methods such as cell microscopy or end point assays.” According to Stoffel, the new E-Plate formate will find its use mainly in cancer research, in basic research (developmental biology, receptor biology, embryology), in dermatology, and in neurobiology.
For the modification, four rows of microelectrode sensors were removed in each well to form a “window” for visual inspection. The gold electrode covers approximately 70 % of the bottom area. The E-Plate VIEW 96 has identical outer dimensions as the E-Plate 96 and allows therefore working with both plates in parallel in RTCA SP and MP Instruments without adapters.
“The new E-Plate features an innovative and unique approach that allows combining impedance-based real-time monitoring with visual inspection of cells,” states Ruedi Stoffel, Life Cycle Leader Cellular Analysis of Roche Applied Science. “We expect that in the long run, the xCELLigence System with the E-Plate VIEW will become the platform of choice also for those users currently working with traditional methods such as cell microscopy or end point assays.” According to Stoffel, the new E-Plate formate will find its use mainly in cancer research, in basic research (developmental biology, receptor biology, embryology), in dermatology, and in neurobiology.
Über Roche Diagnostics GmbH
Headquartered in Basel, Switzerland, Roche is a leader in research-focused healthcare with combined strengths in pharmaceuticals and diagnostics. Roche is the world's largest biotech company with truly differentiated medicines in oncology, virology, inflammation, metabolism and CNS. Roche is also the world leader in in-vitro diagnostics, tissue-based cancer diagnostics and a pioneer in diabetes management. Roche's personalised healthcare strategy aims at providing medicines and diagnostic tools that enable tangible improvements in the health, quality of life and survival of patients. In 2009, Roche had over 80'000 employees worldwide and invested almost 10 billion Swiss francs in R&D. The Group posted sales of 49.1 billion Swiss francs. Genentech, United States, is a wholly owned member of the Roche Group. Roche has a majority stake in Chugai Pharmaceutical, Japan. For more information: www.roche.com.
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