Priority Programme 1464: "Principles and Evolution of Actin-Nucleator Complexes"
Actin filaments assemble from actin monomers at specified subcellular compartments. Owing to the fact that the stable association of actin monomers to form dimers and trimers (a process termed nucleation) is thermodynamically unfavourable, the assembly of actin filaments from actin monomers in vivo requires actin nucleation factors to overcome the kinetic barrier to filament nucleation. Due to the revolutionary gain of knowledge from genome projects, an increasing number of nucleator complexes has recently emerged, which reflects the diversity of actin filament functions and structures formed in different cellular subcompartments, cell types and tissues.
This programme aims at analysing and understanding the function, structure and regulation of actin-nucleator complexes that have emerged throughout evolution. It will include projects that work on the following topics:
- cell biology and structure of actin-nucleator complexes
- biochemistry and modelling of actin nucleation
- visualisation of actin nucleation in vitro and in vivo
- model organisms, bioinformatics and evolution of actin-nucleator complexes
- generation and characterisation of synthetic actin nucleators
- nuclear actin assemblies
The programme will not support projects that study different processes requiring a functional actin cytoskeleton, such as migration, adhesion or endocytosis, without directly focussing on actin nucleation.
Proposals for an initial three-year funding period should be submitted on paper in duplicate, including appendices, and on CD-ROM by 15 October 2009. The CD-ROM should include the proposal and all appendices (publications, CV, etc.), preferebly as PDF (or RTF) files. Proposals must be written in English. Submissions, marked as "SPP 1464", should be addressed to the Deutsche Forschungsgemeinschaft, attn. Dr. Katrin Hahlen, 53170 Bonn.
For additional information please refer to the programme's website: